Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1414)

Philip McKernan: Finding Meaning, Managing Relationships, & Understanding Value - #163

Philip McKernan: Finding Meaning, Managing Relationships, & Understanding Value - #163

Philip McKernan is a philosopher, international best-selling author, and some say an “enlightened hooligan”. Philip has traveled the world speaking about the importance of overcoming personal obstacles, gaining clarity, and cultivating the confidence to believe in yourself, and has shared the stage with esteemed speakers such as Steven Covey, Richard Branson, and the Dalai Lama. He has worked with people from Olympic athletes, TV personalities, entrepreneurs, housewives to billionaires who have gone bankrupt, and everything in between.   Why you should listen –     Philip comes on Bulletproof Radio to discuss how to find more meaning, how to accelerate growth to achieve the next level, whether or not money buys happiness, and how to know what you actually want vs what you think you want. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Okt 201455min

Biohacking Live with Superman, Brandon Routh: Hacking Hollywood & Avoiding Kryptonite - #162

Biohacking Live with Superman, Brandon Routh: Hacking Hollywood & Avoiding Kryptonite - #162

Brandon Routh is an actor and former fashion model, and has appeared in numerous TV shows and movies, however you may know him best from his role portraying The Man of Steel in the 2006 blockbuster film, Superman Returns.   Why you should listen –     Brandon comes on Bulletproof Radio to discuss the impact of the Bulletproof Diet on his family, how he hacks the Hollywood lifestyle, how the Bulletproof Diet has helped to upgrade his acting and performance, and to do a ton of biohacking in person with Dave. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Okt 20141h 6min

Zach Even-Esh: Stress, Recovery, & the Art of Coaching #161

Zach Even-Esh: Stress, Recovery, & the Art of Coaching #161

Zach Even-Esh is the Founder of the Underground Strength Gym, and creator of the Underground Strength Coaching Certification Program. Zach won Teenage Mr. Israel in 1994 in the first of three bodybuilding competitions, and has since trained hundreds of athletes ranging from youth to Olympic level, and also serves as a consultant for several of the top Division 1 wrestling teams in the US. Zach’s online training courses have helped tens of thousands of people around the world develop greater strength in mind, body, and in life.   Why you should listen –     Zach comes on Bulletproof Radio to discuss stress inoculation, the art of coaching, the importance of adequate recovery, and how to know which information you should trust. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Okt 20141h 4min

Leanne Venier: Supersenses, Biophotonics, & Light Spectrum  – #160

Leanne Venier: Supersenses, Biophotonics, & Light Spectrum – #160

Leanne Venier is an international award-winning artist, engineer, scientist, and an expert in the science of color and light therapy. She serves as Director of Outreach for the Institute for Neuroscience and Consciousness Studies (INACS), and has lectured at organizations such as MENSA on the healing and consciousness-raising effects of color, light frequencies, and art. She began her career as a mechanical engineer at Lockheed, but is now pursuing her lifelong passion for health by educating medical practitioners, scientists, and lay people about the most up-to-date scientific research in the fields of phototherapy, light/art/color therapy, and biophotonics.   Why you should listen –     Leanne comes on Bulletproof Radio to discuss the role of light and color in health, the problems with fluorescent lighting and working indoors, and how to heal people with biophotonics and different light spectrums. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Okt 201451min

Dr. Jade Teta: The Metabolic Effect & Being a Diet Detective – #159

Dr. Jade Teta: The Metabolic Effect & Being a Diet Detective – #159

Dr. Jade Teta is an integrative physician, naturopath, and personal trainer with over 25 years of experience helping people achieve their health, weight loss, and fitness goals. He is the founder & CEO of Metabolic Effect Inc., and author of the best-selling book, The Metabolic Effect Diet. He is a regular contributor to many publications, including The Huffington Post, and the Textbook of Natural Medicine, the number one natural medicine textbook used in medical schools across the country. Jade has completed an estimated 10,000 workouts in his lifetime, and has worked with thousands of weight loss and fitness seekers from all over the world through his Metabolic Effect Clinic and online programs. Why you should listen – Jade comes on Bulletproof Radio to discuss how diets are destroying metabolisms and making people fat, the potential holy grail of weight loss research, the New Laws of Metabolism, and how to become your own diet detective. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Okt 201455min

Maneesh Sethi: Hacking Habits, Accountability, & Time Management with Pavlok – #158

Maneesh Sethi: Hacking Habits, Accountability, & Time Management with Pavlok – #158

Maneesh Sethi is the CEO of Pavlok, a new biohacking device that helps people change their habits. Maneesh is also the editor-in-chief of the popular blog, Hack the System, a guide to hacking fame, productivity, travel, languages, exercise, and business. He is an experienced biohacker who has become a “famous” DJ in just 90 days, spent a month living in the wilderness for a month with no backpack, and written an international bestselling book by the age of 14!   Why you should listen –     Maneesh comes on Bulletproof Radio to discuss the science of behavior formation, how habit change works, and how to use technology and biofeedback to transform your life for the better. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Sep 201448min

Dr. Ben Lynch: MTHFR Gene, Overcoming Disease, & the Dangers of Folic Acid – #157

Dr. Ben Lynch: MTHFR Gene, Overcoming Disease, & the Dangers of Folic Acid – #157

Dr. Ben Lynch is a Doctor of Naturopathic Medicine, and one of the foremost experts in the MTHFR gene and how it affects your health. Ben is the Chief Medical Officer for SeekingHealth.com, an online resource designed to help people optimize their health, reduce their risk of disease, and protect themselves in a world full of toxins. Ben believes that disease is not something you live with, but something that can be overcome, and his practice focuses on helping individuals find the info they need to effectively treat their chronic health conditions, and live healthier, upgraded lives.   Why you should listen –     Ben comes on Bulletproof Radio to discuss the little-known MTHFR gene, why folic acid is dangerous, the different genetic tests and interventions available for the MTHFR condition, and why it is important to look at the whole body and connect the dots between all the metabolic systems in the body. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Sep 201459min

Kelly Starrett: Systems Thinking, Movement Standards, & Getting Ready to Run – #156

Kelly Starrett: Systems Thinking, Movement Standards, & Getting Ready to Run – #156

Kelly Starrett is a coach, physical therapist, author, speaker, and creator of a blog that has revolutionized how athletes think about human movement and athletic performance: MobilityWOD.com. Kelly founded one of the first 50 CrossFit Affiliate gyms, San Francisco CrossFit, and focuses on performance-based Orthopedic Sports Medicine to help athletes, military personnel, dancers, and average Joes achieve elite levels of performance and health. Kelly wrote the New York Times Bestseller, Becoming a Supple Leopard, and his second book, Ready to Run, is available to order now!   Why you should listen –     Kelly comes on Bulletproof Radio to discuss the importance of knowing the difference between addressing a problem instead of the symptoms, why you can’t cheat your physiology, how standing desks in school are benefiting children, and how he is applying human performance principles to public health problems. Enjoy! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Sep 20141h 5min

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