GLP-1: A breakthrough for diabetes and obesity

GLP-1: A breakthrough for diabetes and obesity

In the 1980s, scientists made a discovery that would eventually lead to the development of drugs now used worldwide to treat diabetes and to help people manage obesity through weight loss injections.

One of the key scientists behind this breakthrough was Svetlana Mojsov. She discovered that a hormone called GLP-1 (glucagon-like peptide-1) plays an important role in how our bodies respond to food.

Svetlana’s work laid the foundation for a drug company to develop treatments based on GLP-1 — first for type 2 diabetes, and later for weight loss. She tells Gill Kearsley her story.

Eye-witness accounts brought to life by archive. Witness History is for those fascinated by the past. We take you to the events that have shaped our world through the eyes of the people who were there. For nine minutes every day, we take you back in time and all over the world, to examine wars, coups, scientific discoveries, cultural moments and much more. Recent episodes explore everything from the death of Adolf Hitler, the first spacewalk and the making of the movie Jaws, to celebrity tortoise Lonesome George, the Kobe earthquake and the invention of superglue. We look at the lives of some of the most famous leaders, artists, scientists and personalities in history, including: Eva Peron – Argentina’s Evita; President Ronald Reagan and his famous ‘tear down this wall’ speech; Thomas Keneally on why he wrote Schindler’s List; and Jacques Derrida, France’s ‘rock star’ philosopher. You can learn all about fascinating and surprising stories, such as the civil rights swimming protest; the disastrous D-Day rehearsal; and the death of one of the world’s oldest languages.

(Photo: Injection pens. Credit: Carsten Snejbjerg/Bloomberg via Getty Images)

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Scottish Prison Experiment

Scottish Prison Experiment

A Glasgow jail began offering art therapy and a much more relaxed regime to some of its most violent prisoners in 1973. It was known as the Barlinnie 'special unit' and soon its inmates were painting and writing instead of fighting with prison officers. Hear archive voices from the unit alongside Professor Richard Sparks who was a visitor there in the 1990s.Photo: Barlinnie prison. Credit:PA /David Cheskin.

26 Apr 20188min

The Oslo Peace Talks

The Oslo Peace Talks

Top secret negotiations in Norway during 1993 eventually led to an Israeli-Palestinian agreement which became known as the Oslo Accord. Norwegian diplomat Mona Juul was one of the people who helped keep the talks on track. She spoke to Louise Hidalgo for Witness in 2012.(Photo: Yitzhak Rabin, Bill Clinton and Yasser Arafat at the signing ceremony for the Oslo Accord, September 13,1993. Credit: AFP/Getty Images.)

25 Apr 20188min

Swimming The Bering Strait

Swimming The Bering Strait

In 1987, an American endurance swimmer called Lynne Cox swam across the "Ice Curtain" between the USA and the Soviet Union. The Diomede Islands in the Bering Strait are only 2.7 miles apart, but divided by near-freezing water and Cold War rivalry. Lynne Cox spoke to Simon Watts about her swim in 2012. This programme is a rebroadcast. PHOTO: Lynne Cox on the Bering Strait. (Copyright Rich Roberts)

24 Apr 20188min

World War One: The Red Baron

World War One: The Red Baron

Using archive BBC recordings of veterans, we tell the story of one of the most famous figures of World War One. The legendary German air ace Baron von Richthofen who was killed in April 1918. Photo: German First World War air ace Manfred von Richthofen, known as the Red Baron, with a comrade in front of his famous red tri-plane. (Photo by Hulton Archive/Getty Images)

23 Apr 20189min

Earth Day

Earth Day

On April the 22 1970, 20 million Americans came out on to the streets to demonstrate for a healthy, sustainable environment in the first so-called Earth Day. Mass rallies were held to highlight concerns about pollution and the destruction of America's natural heritage. Some see it as the birth of the modern environmental movement. Farhana Haider spoke to Denis Hayes, the organiser of that first Earth Day. Photo credit: Robert Sabo-Pool/Getty Images

20 Apr 20189min

The Last Keeper of the Light

The Last Keeper of the Light

The lighthouse on Skellig Michael off the south west coast of Ireland was continuously occupied by lighthouse keepers for more than 150 years until its automation 1987. Skellig Michael has now become a tourist attraction since its ancient monastery was used as a location in recent Star Wars films. The last keeper of the light there was Richard Foran who has been speaking to Catherine Harvey about life on the remote island. Photo: The lighthouses on Skellig Michael. Credit: Alamy

19 Apr 20189min

Rebuilding the Site of the Twin Towers

Rebuilding the Site of the Twin Towers

After the September 11th attacks brought down the Twin Towers, reconstruction began at the devastated area in New York in April 2006. Rachael Gillman spoke to TJ Gottesdiener, who was a managing partner at the architecture firm tasked with designing a new skyscraper on the site.(Photo credit: Robert Sabo-Pool/Getty Images)

17 Apr 20189min

World War One: Germany's Spring Offensive 1918

World War One: Germany's Spring Offensive 1918

In early 1918, Germany launched a huge offensive on the Western Front in a last great gamble to win the war. Following Russia's withdrawal from the war, Germany could move up to a million soldiers from the Eastern Front to the West to launch a decisive attack. Their plan was to break through British and French lines and force an end to the war, before American power could bolster the Allied cause. They came close to succeeding. Using recordings from the BBC Archive, we hear from German and British soldiers who faced each other in the spring of 1918. Photo: German troops advance in the sector near Villers-Bretonneux during Germany's Spring Offensive 1918. (Hulton Archive/Getty Images)

16 Apr 20189min

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