How Biohackers Use Nicotine WITHOUT Getting Addicted  : 1350

How Biohackers Use Nicotine WITHOUT Getting Addicted : 1350

This is Part 2 of the Nicotine Masterclass. If you haven’t heard Part 1, start there for a full breakdown of nicotine’s mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance.


Nicotine is one of the most misunderstood nootropics in the world—and one of the most powerful tools for brain optimization and longevity when used correctly. In this episode, Host Dave Asprey breaks down how to harness nicotine for cognitive enhancement, metabolism, and human performance without falling into addiction. You’ll learn the real science behind dosage, timing, and cycling, plus how nicotine interacts with mitochondria, acetylcholine, and neuroplasticity to boost focus, motivation, and mental energy.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


This is Part 2 of the Nicotine Masterclass. If you haven’t heard Part 1, start there for a full breakdown of nicotine’s mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance.


Host Dave Asprey reveals practical biohacking templates for using nicotine safely and effectively—covering metabolism genetics, stack combinations, and how nicotine fits into a smarter not harder lifestyle. You’ll discover how low-dose nicotine can support attention, memory, and even protect against neurodegenerative diseases like Alzheimer’s and Parkinson’s. Dave also shares his own five-year nicotine protocol, how he avoided dependence, and why nicotine can be a game-changer for brain and mitochondrial performance when used intelligently.


You’ll Learn:

• How to use nicotine as a safe, powerful nootropic for brain optimization and focus

• The genetics of nicotine metabolism and why dose timing matters

• How to stack nicotine with caffeine, theanine, and rhodiola for maximum energy and motivation

• Why nicotine enhances mitochondria and PGC-1α for better metabolism and longevity

• The truth about nicotine tolerance, cycling, and how to avoid addiction

• How nicotine affects sleep, neuroplasticity, and dopamine signaling

• What science says about nicotine’s protective effects against Alzheimer’s and Parkinson’s

• How to integrate nicotine into a complete biohacking protocol with fasting, ketosis, and supplements


This episode is essential for anyone exploring biohacking, functional medicine, fasting, ketosis, sleep optimization, and cognitive resilience. You’ll learn how nicotine stacks with caffeine, theanine, rhodiola, and supplements for sharper thinking and sustained focus—plus the key mistakes to avoid so you don’t wreck your sleep or metabolism. Whether you’re a seasoned biohacker or just beginning your journey, this episode gives you the science, tools, and protocols to elevate your mind and body safely.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nicotine biohacking, nicotine masterclass, Dave Asprey nicotine, nicotine nootropics, nicotine cognitive enhancement, nicotine mitochondria, nicotine and dopamine, nicotine addiction prevention, nicotine cycling, nicotine dosage, nicotine metabolism, nicotine tolerance, nicotine and longevity, nicotine patch benefits, nicotine for focus, nicotine and acetylcholine, nicotine and caffeine stack, nicotine sleep effects, nicotine and Parkinson’s, nicotine brain optimization


** Listen to part 1 here: https://www.youtube.com/watch?v=WjehLsHaRnE&t=1063s**


Thank you to our sponsors!

-GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air.

-Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave.

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.

-MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

00:00 – Trailer

01:25 – Review of Pt 1

02:48 – Genetics & Metabolism

06:05 – Stacking with Other Compounds

09:23 – Tolerance & Dependence

13:42 – Fertility & Contraindications

17:05 – Real World Use Templates

21:40 – Travel & Jet Lag Protocol

24:29 – Biohacking Lifestyle Integration

25:31 – Longevity & Neuroprotection

28:24 – Medical Applications & Research

31:51 – Final Thoughts & Summary

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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#61 Gluten Sensitivity, Celiacs & Bulletproofing Your Gut, with Dr. Tom O'Bryan

#61 Gluten Sensitivity, Celiacs & Bulletproofing Your Gut, with Dr. Tom O'Bryan

Have you heard? Gluten is harmful, but do you know why? Dr. Tom O’Bryan explains away dietary gluten, how it is detrimental to your health, and why it keeps you from being optimal – in a big way! He talks about his 30 years of experience in researching Celiac disease and gluten sensitivity and how you can drastically increase the quality of your life by getting rid of gluten in your diet. We also talk about the number one supplement he recommends to Bulletproof your gut, how gluten is like morphine, and if there are such a thing as “good” grains.  If you want to understand gluten in a way you never have before and learn how it affects your body, this episode   is for you! Dr. Tom O’Bryan is a nationally recognized speaker, workshop leader, healer, and researcher specializing in Celiac disease & gluten intolerance. He is a highly esteemed clinician in treating chronic disease and metabolic disorders from a Functional Medicine perspective. Dr. O’Bryan is the Sherlock Holmes for chronic disease & metabolic disorders, a triathalete, and a second-degree black belt in Aikido. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Sep 201352min

#60 Orgasmic Meditation & Hacking Your Sex Life, with Dr. Pooja Lakshmin

#60 Orgasmic Meditation & Hacking Your Sex Life, with Dr. Pooja Lakshmin

Discover orgasmic meditation (OMing) and the science behind it with Dr. Pooja Lakshmin, M.D., the CSO of OneTaste, and scientist at Rutgers University Newark Orgasm Laboratory. This episode discusses the relationship between orgasm and the nervous system, the importance of mindfulness, and how often men and women should orgasm for maximum performance in life. Be sure not to miss this stimulating episode! Formerly a psychiatrist at Stanford hospital, Pooja switched career paths after experimenting with OMing and researching the science behind it. She later moved across the country to New York City to study the neuroscience involved in OMing through fMRI imaging and clinical studies. Currently, Pooja continues to conduct OMing studies, while also venturing into further researching the male orgasm. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Sep 201346min

#59 Hacking Productivity, Forming Habits & 'Lift' iPhone App, With Tony Stubblebine

#59 Hacking Productivity, Forming Habits & 'Lift' iPhone App, With Tony Stubblebine

Learn how to unlock your Bulletproof potential from the CEO of the habit-building app, Lift. Tony Stubblebine shares his take on what habits are good to form, and how to develop and sustain those habits by creating a supportive lifestyle. Tony and I also dug deep into the performance and emotional aspects of being a CEO. If you are a productivity hack or a high performing businessperson, than you do not want to miss this episode! Tony Stubblebine co-founded Lift based on the idea that positive reinforcement and community support could be deployed universally to help people achieve their goals. Prior to Lift, he was the founder and CEO of CrowdVine Event Social Networks, which builds simple and powerful software to help people connect and meet. He was also a part of the Wesabe launch team, Director of Engineering at Odeo.com and O'Reilly Media, and authored Regular Expression Pocket Reference. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Sep 201354min

#58 Food Choices, Willpower & Sugar Cravings with Michael Fishman

#58 Food Choices, Willpower & Sugar Cravings with Michael Fishman

Take control of your food choices, understand your willpower, and combat sugar cravings by listening to this episode with expert health marketing advisor, Michael Fishman. You will hear how Michael radically changed his diet to be a healthier, more in control and happier version of himself, and how you can do that too. Michael Fishman is a leading advisor on marketing, positioning and strategy for health, wellness and personal development businesses and personalities such as Rodale's Prevention and Men's Health publishing brands, Dr. Andrew Weil, Dr. Mark Hyman, Dr. Christiane Northrup, Dr. Dean Ornish and many others. Michael is also a highly sought after speaker on how marketing language, customer care and work culture combine to take companies from merely good to the beloved best at what they do. He created the annual Consumer Health Summit, which is the preeminent invitational forum for CEOs, entrepreneurs and marketing leaders in health and wellness. He is also a co-founder of BehaviorCon, a conference on marketing and consumer psychology.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Aug 201347min

#57 Becoming Alpha, Dispelling Myths & Making Changes, with Adam Bornstein

#57 Becoming Alpha, Dispelling Myths & Making Changes, with Adam Bornstein

As a top health and fitness editor and best-selling author, Adam Bornstein came on the show to share what it means to be ‘Alpha’ and how being bulletproof is possible for everyone. In this episode, Adam and I discuss our shared egg obsession, whether cheat days are helpful or harmful, and how mental barriers keep you from achieving the best version of yourself. You will even get a glimpse into the workings of mainstream media, research, and health journalism. Adam Bornstein is a biohacking, solutions oriented machine! Adam has been named “one of the most influential people in health.” He’s a long time health and fitness writer and editor for magazines like Men’s Health and Livestrong, and best-selling author of four fitness books, including his most recent book “Man 2.0 Engineering the Alpha: A Real World Guide to an Unreal Life: Build More Muscle. Burn More Fat. Have More Sex” See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Aug 201354min

#56 Biohacking Apocalypse Survival, Stress Inoculation & Shamans, with Sam Sheridan

#56 Biohacking Apocalypse Survival, Stress Inoculation & Shamans, with Sam Sheridan

In an apocalypse, how would you biohack your survival? This episode dives into answering this question and discusses all things stress-related. It was a blast having Sam Sheridan, best selling author of The Disaster Diaries: How I Learned to Stop Worrying and Love the Apocalypse, on the show to talk about a wide variety of topics ranging from endurance vs. interval training to Cooper’s Color Code and shamans. You’ll hear about the science and psychology of stress, the best way to handle stress, and how to better your chances of surviving an apocalypse. Sam Sheridan was an amateur MMA fighter, EMT, wild-land fire fighter, cowboy, sailor and worked construction at the South Pole. He is also the best selling author of A Fighters Heart: One Man’s Journey Through the World of Fighting, he Fighters Mind: Inside the Mental Game. During research for his latest book The Disaster Diaries: Sam immerses himself in the survivalist and dooms-day preparation subculture by:  Attending stunt driving school;  Learning the art of eskrima (Filipino knife fighting); Participating in Cody Lundin’s (Dual Survival on Discovery Channel) Aboriginal Living Skills School; Learning how to steal a car with ex-gang bangers in Los Angeles. A large portion of The Disaster Diaries explains the bio-chemical cocktail that our bodies produce during moments of intense stress (i.e.  an apocalypse.)  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Aug 201350min

#55 Fitness, Nutrition & Bulletproof Habits, with High Performance Health Coach, Yuri Elkaim

#55 Fitness, Nutrition & Bulletproof Habits, with High Performance Health Coach, Yuri Elkaim

From professional athlete to high performance health coach, Yuri Elkaim joins us today to talk about (almost) all things Bulletproof. In his goal to help 10,000,000 people become healthier, Yuri will share his take on raw food, the “fruit & veg” argument, exercise vs. rest, habits, and more! If you are an athlete (or biohacker) looking for 1 or 2 tips to take your performance to the next level, this is the show for you. Yuri Elkaim is a registered holistic nutritionist, fitness expert, and highly sought after high performance health coach. He’s also a former professional soccer player and served as the Head Strength & Conditioning and Nutrition Coach for men’s soccer at the University of Toronto for 7 seasons. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Aug 201346min

#54 Neurofeedback Technology, Best Biohack Yet, with Dr. Valdeane Brown

#54 Neurofeedback Technology, Best Biohack Yet, with Dr. Valdeane Brown

This episode is all about the most effective biohack I’ve experience yet – NeurOptimal® brain training. Dr. Valdeane Brown, Founder of NeurOptimal, came on the show to explain how this technology takes your performance to uncharted levels! The NeurOptimal brain trainer is the most powerful and affordable neurofeedback technology available. You will get to hear about the EEG technology and how it transforms your brain, upgrade athletic performance, and even help with migraines, PTSD, and abusive relationships. Does this sound too good to be true? Listen for yourself… Dr. Valdeane W. Brown is an internationally recognized "trainer of neurofeedback trainers", who has taught and consulted widely on personal and organizational transformation. With a Ph.D. in Clinical Psychology and a background in math, physics, computer programming, philosophy, yoga, meditation and martial arts, Dr. Brown brings a presence and precision to his work. This is further informed by a profound sense of compassion, a facility with energy dynamics and a deep commitment to revealing the elegant simplicity inherent in learning and transformation. Developer of the Five Phase Model and co-creator with his wife Sue of the Period 3 Approach to Clinical Neurofeedback, Dr. Brown has realized his vision of a truly comprehensive training system in NeurOptimal. His vision in bringing NeurOptimal to the world is to make personal transformation effortless and available to all. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Aug 20131h 1min

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