Biohacking News Weekly Update : 1351

Biohacking News Weekly Update : 1351

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.


This episode covers:


Vitamin D as the Surprising “Anti-Aging Pill”

A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.

Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm


The Supercentenarian Gene That Rejuvenates Old Hearts

Researchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.

Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html


FDA Closes the “GRAS” Loophole — Supplements Enter a New Era

The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.

Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter


Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch

Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.

Source: University of Basel — https://www.unibas.ch/en/News-Events/News/Uni-Research/Longevity-research—Dietary-stress-supports-healthy-aging.html

Further reading: Neuroscience News — https://neurosciencenews.com/dietary-rna-cellular-aging-29757/


Your Medical Avatar Is Coming — The Digital Twin of You

Forbes reports on the rise of personalized “medical avatars” — AI-powered digital twins built from your wearables and biometrics that can predict health risks, recommend interventions, and evolve alongside your biology. Doctors like Daniel Kraft call it generative health — a revolution in predictive medicine where your data literally becomes your doctor.

Source: Forbes Innovation — https://www.forbes.com/sites/johnwerner/2025/10/21/wearables-ai-and-your-personal-medical-avatar/


This is essential listening for fans of biohacking, human performance, functional medicine, and longevity sciencewho want real, actionable tools from Dave Asprey — the father of biohacking and founder of Bulletproof Coffee.


With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your lifespan, and upgrade every system in your body and mind.


New episodes drop every Tuesday, Thursday, Friday, and Sunday. Dave asks the questions no one else will — and gives you the science-backed tools to become stronger, smarter, and more resilient.


Keywords: vitamin D longevity, telomeres, BPIFB4 gene, cardiac rejuvenation, supplement regulation, GRAS FDA, autophagy, microbiome, fermented foods, biohacking news, medical avatar, digital twin, predictive medicine, Daniel Kraft, quantum health, wearable AI, Dave Asprey, The Human Upgrade


Thank you to our sponsors!

TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off.

HeartMath | Go to https://www.heartmath.com/dave to save 15% off.


Timestamps:

0:00 — Introduction

0:18 — Story 1: Vitamin D & Telomeres

1:02 — Story 2: Longevity Gene Therapy

1:49 — Story 3: FDA Supplement Reform

2:38 — Story 4: Gut Bacteria & Autophagy

3:46 — Story 5: Medical Avatars

4:53 — Weekly Protocol

5:42 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1415)

Doug McGuff: Myokines, & the Endocrine Nature of Muscles - #164

Doug McGuff: Myokines, & the Endocrine Nature of Muscles - #164

Dr. Doug McGuff is an Emergency Medicine Physician, exercise science researcher, and weight lifter. In addition to his work at Blue Ridge Emergency Physicians, P.A., Doug also owns and operates his own gym, Ultimate Exercise, and co-authored the best-selling book Body by Science, along with John Little.   Why you should listen –     Doug comes on Bulletproof Radio to discuss myokines and their role in muscular training, the role of the gut microbiome in fighting inflammation, how to control your nerves with stress inoculation, and the science behind oxygen saturation, breathing, & exercise. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Okt 20141h 10min

Philip McKernan: Finding Meaning, Managing Relationships, & Understanding Value - #163

Philip McKernan: Finding Meaning, Managing Relationships, & Understanding Value - #163

Philip McKernan is a philosopher, international best-selling author, and some say an “enlightened hooligan”. Philip has traveled the world speaking about the importance of overcoming personal obstacles, gaining clarity, and cultivating the confidence to believe in yourself, and has shared the stage with esteemed speakers such as Steven Covey, Richard Branson, and the Dalai Lama. He has worked with people from Olympic athletes, TV personalities, entrepreneurs, housewives to billionaires who have gone bankrupt, and everything in between.   Why you should listen –     Philip comes on Bulletproof Radio to discuss how to find more meaning, how to accelerate growth to achieve the next level, whether or not money buys happiness, and how to know what you actually want vs what you think you want. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Okt 201455min

Biohacking Live with Superman, Brandon Routh: Hacking Hollywood & Avoiding Kryptonite - #162

Biohacking Live with Superman, Brandon Routh: Hacking Hollywood & Avoiding Kryptonite - #162

Brandon Routh is an actor and former fashion model, and has appeared in numerous TV shows and movies, however you may know him best from his role portraying The Man of Steel in the 2006 blockbuster film, Superman Returns.   Why you should listen –     Brandon comes on Bulletproof Radio to discuss the impact of the Bulletproof Diet on his family, how he hacks the Hollywood lifestyle, how the Bulletproof Diet has helped to upgrade his acting and performance, and to do a ton of biohacking in person with Dave. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Okt 20141h 6min

Zach Even-Esh: Stress, Recovery, & the Art of Coaching #161

Zach Even-Esh: Stress, Recovery, & the Art of Coaching #161

Zach Even-Esh is the Founder of the Underground Strength Gym, and creator of the Underground Strength Coaching Certification Program. Zach won Teenage Mr. Israel in 1994 in the first of three bodybuilding competitions, and has since trained hundreds of athletes ranging from youth to Olympic level, and also serves as a consultant for several of the top Division 1 wrestling teams in the US. Zach’s online training courses have helped tens of thousands of people around the world develop greater strength in mind, body, and in life.   Why you should listen –     Zach comes on Bulletproof Radio to discuss stress inoculation, the art of coaching, the importance of adequate recovery, and how to know which information you should trust. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Okt 20141h 4min

Leanne Venier: Supersenses, Biophotonics, & Light Spectrum  – #160

Leanne Venier: Supersenses, Biophotonics, & Light Spectrum – #160

Leanne Venier is an international award-winning artist, engineer, scientist, and an expert in the science of color and light therapy. She serves as Director of Outreach for the Institute for Neuroscience and Consciousness Studies (INACS), and has lectured at organizations such as MENSA on the healing and consciousness-raising effects of color, light frequencies, and art. She began her career as a mechanical engineer at Lockheed, but is now pursuing her lifelong passion for health by educating medical practitioners, scientists, and lay people about the most up-to-date scientific research in the fields of phototherapy, light/art/color therapy, and biophotonics.   Why you should listen –     Leanne comes on Bulletproof Radio to discuss the role of light and color in health, the problems with fluorescent lighting and working indoors, and how to heal people with biophotonics and different light spectrums. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Okt 201451min

Dr. Jade Teta: The Metabolic Effect & Being a Diet Detective – #159

Dr. Jade Teta: The Metabolic Effect & Being a Diet Detective – #159

Dr. Jade Teta is an integrative physician, naturopath, and personal trainer with over 25 years of experience helping people achieve their health, weight loss, and fitness goals. He is the founder & CEO of Metabolic Effect Inc., and author of the best-selling book, The Metabolic Effect Diet. He is a regular contributor to many publications, including The Huffington Post, and the Textbook of Natural Medicine, the number one natural medicine textbook used in medical schools across the country. Jade has completed an estimated 10,000 workouts in his lifetime, and has worked with thousands of weight loss and fitness seekers from all over the world through his Metabolic Effect Clinic and online programs. Why you should listen – Jade comes on Bulletproof Radio to discuss how diets are destroying metabolisms and making people fat, the potential holy grail of weight loss research, the New Laws of Metabolism, and how to become your own diet detective. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Okt 201455min

Maneesh Sethi: Hacking Habits, Accountability, & Time Management with Pavlok – #158

Maneesh Sethi: Hacking Habits, Accountability, & Time Management with Pavlok – #158

Maneesh Sethi is the CEO of Pavlok, a new biohacking device that helps people change their habits. Maneesh is also the editor-in-chief of the popular blog, Hack the System, a guide to hacking fame, productivity, travel, languages, exercise, and business. He is an experienced biohacker who has become a “famous” DJ in just 90 days, spent a month living in the wilderness for a month with no backpack, and written an international bestselling book by the age of 14!   Why you should listen –     Maneesh comes on Bulletproof Radio to discuss the science of behavior formation, how habit change works, and how to use technology and biofeedback to transform your life for the better. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Sep 201448min

Dr. Ben Lynch: MTHFR Gene, Overcoming Disease, & the Dangers of Folic Acid – #157

Dr. Ben Lynch: MTHFR Gene, Overcoming Disease, & the Dangers of Folic Acid – #157

Dr. Ben Lynch is a Doctor of Naturopathic Medicine, and one of the foremost experts in the MTHFR gene and how it affects your health. Ben is the Chief Medical Officer for SeekingHealth.com, an online resource designed to help people optimize their health, reduce their risk of disease, and protect themselves in a world full of toxins. Ben believes that disease is not something you live with, but something that can be overcome, and his practice focuses on helping individuals find the info they need to effectively treat their chronic health conditions, and live healthier, upgraded lives.   Why you should listen –     Ben comes on Bulletproof Radio to discuss the little-known MTHFR gene, why folic acid is dangerous, the different genetic tests and interventions available for the MTHFR condition, and why it is important to look at the whole body and connect the dots between all the metabolic systems in the body. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Sep 201459min

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