Biohacking News Weekly Update : 1351

Biohacking News Weekly Update : 1351

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.


This episode covers:


Vitamin D as the Surprising “Anti-Aging Pill”

A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.

Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm


The Supercentenarian Gene That Rejuvenates Old Hearts

Researchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.

Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html


FDA Closes the “GRAS” Loophole — Supplements Enter a New Era

The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.

Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter


Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch

Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.

Source: University of Basel — https://www.unibas.ch/en/News-Events/News/Uni-Research/Longevity-research—Dietary-stress-supports-healthy-aging.html

Further reading: Neuroscience News — https://neurosciencenews.com/dietary-rna-cellular-aging-29757/


Your Medical Avatar Is Coming — The Digital Twin of You

Forbes reports on the rise of personalized “medical avatars” — AI-powered digital twins built from your wearables and biometrics that can predict health risks, recommend interventions, and evolve alongside your biology. Doctors like Daniel Kraft call it generative health — a revolution in predictive medicine where your data literally becomes your doctor.

Source: Forbes Innovation — https://www.forbes.com/sites/johnwerner/2025/10/21/wearables-ai-and-your-personal-medical-avatar/


This is essential listening for fans of biohacking, human performance, functional medicine, and longevity sciencewho want real, actionable tools from Dave Asprey — the father of biohacking and founder of Bulletproof Coffee.


With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your lifespan, and upgrade every system in your body and mind.


New episodes drop every Tuesday, Thursday, Friday, and Sunday. Dave asks the questions no one else will — and gives you the science-backed tools to become stronger, smarter, and more resilient.


Keywords: vitamin D longevity, telomeres, BPIFB4 gene, cardiac rejuvenation, supplement regulation, GRAS FDA, autophagy, microbiome, fermented foods, biohacking news, medical avatar, digital twin, predictive medicine, Daniel Kraft, quantum health, wearable AI, Dave Asprey, The Human Upgrade


Thank you to our sponsors!

TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off.

HeartMath | Go to https://www.heartmath.com/dave to save 15% off.


Timestamps:

0:00 — Introduction

0:18 — Story 1: Vitamin D & Telomeres

1:02 — Story 2: Longevity Gene Therapy

1:49 — Story 3: FDA Supplement Reform

2:38 — Story 4: Gut Bacteria & Autophagy

3:46 — Story 5: Medical Avatars

4:53 — Weekly Protocol

5:42 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Podcast #10: The Man Who Would Stop Time

Podcast #10: The Man Who Would Stop Time

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Podcast #9: How To Profit From Provocation with Linda Bernardi

Podcast #9: How To Profit From Provocation with Linda Bernardi

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Podcast #8: Quantifying Recovery With RestWise

Podcast #8: Quantifying Recovery With RestWise

RestWise is the first software program that enables athletes to track their recovery.  This system is being used by everyone from the world’s top olympians to the weekend warriors.  Using science based metrics such as heart rate, blood oxygen saturation, mood, and sleep, RestWise gives athletes the ability to look at their recovery over time and make changes based on their results.  Jeff Hunt, the cofounder, was nice enough to spend some time talking to us about this unique piece of technology. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Okt 201129min

Podcast #7: Low-Carb Diets with Adam Kosloff

Podcast #7: Low-Carb Diets with Adam Kosloff

Adam Kosloff is a journalist and blogger who writes about low-carb diets (among other things).  We talk about how his knowledge has evolved over time, and the merits of low-carb dieting.  Adam shares tips on how to make low-carb diets work for you, such as exercise recommendations, tricks to kill carb cravings, and how to overcome the hardest part about eating low-carb. Sign up to have these interviews delivered straight to your email or RSS(subscribing to the podcast makes you Bulletproof). See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Okt 201135min

Podcast #6: Optimum Performance Training with James Fitzgerald

Podcast #6: Optimum Performance Training with James Fitzgerald

28 Sep 201127min

#5: How To Quantify Fatigue Like Never Before

#5: How To Quantify Fatigue Like Never Before

Rick Green and John Kalns have created the first test that can objectively measure fatigue.  Using an at-home test for salivary peptides, you can now gauge exactly how much stress your body is under.  This test can be used by athletes, or businessmen and entrepreneurs who burn the candle at both ends.  This is the first test which allows you to know when you’re really pushing your self too far. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Sep 201139min

#4: Evolutionary Psychiatry With Emily Deans (Paleo Brain Hacking)

#4: Evolutionary Psychiatry With Emily Deans (Paleo Brain Hacking)

Emily Deans is a board certified adult psychiatrist who uses evolutionary clues to solve modern mental illnesses.  She runs a popular blog called Evolutionary Psychiatry, and another blog on psychology today.  Emily is considered one of the top experts on the connection between nutrition and mental performance.  She is well respected in the “paleosphere”, and was kind enough to share her knowledge on Upgraded Self Radio. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Sep 20111h

#3: Hacking Fatigue With Tim Noakes (Plus More 4 Hour Body Fun)

#3: Hacking Fatigue With Tim Noakes (Plus More 4 Hour Body Fun)

Dr. Tim Noakes is one of the world’s foremost exercise scientists and the author of numerous books including the Lore of Running.  From the University of Cape Town exercise research center, Dr. Noakes has worked with some of the greatest athletes of all time.  His research is redefining the way we think about fatigue in sports and regular life.  A lifelong runner (71 marathons and ultra-marathons), writer, and researcher (and more recently, a paleo eater), Tim Noakes has used his knowledge to hack the human mind for improved athletic performance.  Whether you’re an athlete or a cubicle dweller, you need to here this interview. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Sep 20111h

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