The Neuro Experience12 Sep 2023

Unpacking Longevity and the NAD Controversy | Dr Charles Brenner, PhD

Charles Brenner is a leading Global expert in the biology, chemistry and Medicine of NAD the central Catalyst of metabolism he currently works at City of Hope in Los Angeles as professor and chair of the Department of diabetes and cancer metabolism. I'm intrigued by Charles' recent rebuttal to David Sinclair's thesis regarding longevity. "Surtuins are not conserved longevity genes" published in the Journal of Life metabolism in October 2022. In this episode Charles and I discuss this paper and his view on the science of longevity. We will expand on this while also discussing various other topics related to NAD, use cases for NR, metabolism and where influencers go wrong in the nutrition space. If you have any additional questions you would like answered in the future, let me know in the comments. Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at http://insidetracker.com/louisa Chapters: 00:00:00 - The Role of NAD in Metabolism and Living Things 00:11:18 - NAD and the De Novo Pathway 00:21:50 - The Composition of NAD and NR 00:33:07 - The Innate Immune Response and NAD Churning 00:44:08 - The Longevity of Naked Mole Rats and Humans 00:55:27 - The Myth of Sirtuin Genes and Longevity 01:06:26 - Reproducibility Issues and False Claims 01:17:32 - Targeting the Aging System 01:27:44 - The Uselessness of Age Tests 01:38:26 - Q&A on Twitter Optimise your hydration and get a free sample pack of electrolytes at http://drinklmnt.com/neuro Connect with Dr Charles Brenner: - Twitter: https://twitter.com/CharlesMBrenner - Website: https://www.brennerlab.net/ The best way to support the show is to use the products and services offered by our sponsors. Connect with Dr Charles Brenner: - Twitter: https://twitter.com/CharlesMBrenner - Website: https://www.brennerlab.net/ *** The Neuro Athletics Newsletter: https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

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Top Flow Researcher: How to Get 5 Days of Work Done in 1 Day | Steven Kotler

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Surgeon Exposes How Health Insurance Tricks You Into Overpaying | Dr. Elisabeth Potter

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78.3% Alzheimer's Patients Are Women: Here’s How to Fix It. (Yes really)

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21 Juli 32min

Exercise Expert: The Workout That Reverses 20 Years of Aging

Six days before he sat down for this conversation, he ran a marathon. Then he explained what the race did to his brain. When you run 26 miles and your glycogen runs out, your brain still needs energy,...

16 Juli 1h 2min

Growing $20,000-a-Gram Medicine in a Warehouse | Sam Bertram

"Everyone gets cancer five times a day — your body already knows how to take care of it." Sam Bertram is the co-founder and CEO of OnePointOne, the vertical-farming company behind the Willo brand. Wi...

14 Juli 1h 4min