64. The Truth About Weight Gain, Menopause, and “Weight Loss Drugs” — with Dr. Sasha High
Aging Powerfully with Melissa Grelo23 Okt 2025

64. The Truth About Weight Gain, Menopause, and “Weight Loss Drugs” — with Dr. Sasha High

If you’ve ever wondered why your body seems to be changing through midlife — even when your habits haven’t — this episode is a must-listen.

Melissa sits down once again with Dr. Sasha High (@sashahighmd), obesity physician and leading voice in metabolic health, for an eye-opening conversation about weight gain and weight loss during the menopause transition.

Dr. High breaks down the latest science behind today’s most talked-about obesity medications — and why calling them “weight loss drugs” is not only misleading, but potentially dangerous. She explains who these medications are really for, who shouldn’t be taking them, and why trendy “microdosing” approaches can backfire in serious ways.

If you’ve struggled with midlife weight changes, felt confused by conflicting advice, or just want the truth — free of diet fads and fear — Dr. High’s compassionate, evidence-based approach will change the way you think about your body, your metabolism, and your health.

In this episode:



  • Why weight gain during menopause is normal — and what’s really behind it
  • The science (and myths) of new obesity treatment medications
  • Why “weight loss drug” culture is dangerous and inaccurate
  • The truth about “microdosing” and other social media fads
  • How Dr. High helps menopausal women find real, sustainable, science-backed solutions

Listen now — and start aging powerfully, inside and out.

This episode is supported by Aging Powerfully with Melissa Grelo: The Retreat and partners @GoodLifeFitness, @lovemy.iris, @avene and @rexalldrugstoreofficial.

Tech and Audio Producer: Drew Garner

Producer: Melissa Grelo

For any partnership inquires, contact beverly@agingpowerfullywithmelissagrelo.com

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