49ers Talk: A San Francisco 49ers Podcast3 Nov 2025

49ers bounce back in Week 9 with decisive victory over Giants

The 49ers bounced back in a big way with a statement win over the New York Giants. San Francisco was laser focused in all three phases, never looking back after taking a second-quarter lead. The 49ers' offense was humming all afternoon, scoring a season-high 34 points while Christian McCaffrey added a pair of touchdowns along with 173 total yards. San Francisco's win didn't come without cost, as 2025 first-round draft pick Mykel Williams went down with a knee injury late in the fourth quarter. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan break down how the 49ers responded to their disappointing loss against the Houston Texans with an offensive outburst in Sunday's win over New York. They also review how Williams' potential loss could affect the 49ers' approach at the NFL trade deadline. Finally, with a pivotal divisional matchup with the Los Angeles Rams looming, Matt and Jennifer discuss Brock Purdy's progress as the quarterback works back from a toe injury.

(1:30) Reaction to Mykel Williams' knee injury
(3:00) Does Williams' injury stunt his development?
(7:00) 49ers' offense showed real execution vs. Giants
(10:00) QB Mac Jones maybe tougher than given credit for
(11:00) Trade deadline discussion given the 49ers' mounting injuries
(12:00) Would the 49ers mortgage their future draft capital for a big-name trade acquisition?
(26:00) Will Brock Purdy start in Week 10 vs. Rams?
(30:00) Reviewing the 49ers' dynamic backfield pairing

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