November 11, 2025: Precision, Place, and the Future of Cardiovascular Prediction | JACC This Week
JACC This Week3 Nov 2025

November 11, 2025: Precision, Place, and the Future of Cardiovascular Prediction | JACC This Week

In this week's JACC podcast, Editor-in-Chief Dr. Harlan Krumholz explores how context, precision, and physiology converge to shape modern cardiovascular care. He opens with an editorial on "The Geography Gap," challenging the one-size-fits-all approach to cardiovascular risk models that ignore geographic variation in disease outcomes. Other featured studies in this issue include trials (OCEAN Mitral, PULSE), optimizing outcomes after transcatheter mitral repair, plus uncovering genetic links between placental malperfusion and congenital heart disease, evaluating CT angiography follow-up after left main PCI, and refining emergency triage with high-sensitivity troponin testing. Dr. Krumholz also speaks to editorials in this issue providing insight on the accompanying JACC articles, and a HeartBeat submission, with a reflection on balance and compassion in pediatric cardiology. Finally, he touches on our other JACC journal content, including new findings on blood groups and COVID-19 cardiovascular outcomes, and the first JACC: Basic to Translational Science Editor's page from the new editor-in-chief, Matthias Nahrendorf, MD, PhD, on the evolving landscape of translational science. This week in JACC highlights cardiology's movement toward more localized, integrated, and human-centered precision medicine.

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Season 2 Wrap-Up: Thank You, Reflections, and What Comes Next | JACC This Week

Season 2 Wrap-Up: Thank You, Reflections, and What Comes Next | JACC This Week

In this special Season 2 wrap-up of JACC This Week, Dr. Harlan Krumholz and Dr. Carolyn Lam reflect on the pilot season, the energy of ACC.26, and what they've learned from listeners along the way. Fr...

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March 31, 2026: Global Cardiovascular Insights & Breakthroughs from China | JACC This Week

March 31, 2026: Global Cardiovascular Insights & Breakthroughs from China | JACC This Week

This week's edition of JACC This Week brings Dr. Carolyn Lam and Dr. Harlan Krumholz into a deep exploration of a special issue devoted to innovative cardiovascular research emerging from China. As th...

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March 24, 2026: Cardiometabolic Health, COVID Impact & Prevention Science | JACC This Week

March 24, 2026: Cardiometabolic Health, COVID Impact & Prevention Science | JACC This Week

Drs. Carolyn Lam and Harlan Krumholz unpack new JACC research on cardiometabolic health, highlighting how COVID‑19 shaped cardiovascular care, mortality patterns, and disparities. They also break down...

24 Mars 13min

March 17, 2026: Heart Failure, Chagas Research & AI in Cardiology | JACC This Week

March 17, 2026: Heart Failure, Chagas Research & AI in Cardiology | JACC This Week

In this episode, Dr. Carolyn Lam and Dr. Harlan Krumholz break down key studies from this week's JACC issue, including new evidence on Chagas‑related heart failure, updated diastolic function guidelin...

17 Mars 17min

March 10, 2026: Inside JACC Stats: The State of CV Health in Focus | JACC this Week

March 10, 2026: Inside JACC Stats: The State of CV Health in Focus | JACC this Week

Dr. Carolyn Lam and Dr. Harlan Krumholz sit down with Dr. Rishi Wadhera to unpack the first-ever JACC Cardiovascular Statistics issue. They explore why this annual report matters, the key trends in U....

10 Mars 18min

March 3, 2026: Hypertrophic Cardiomyopathy  in Focus—MAPLE-HCM Trial, Myosin Inhibitors & What Improvement Really Means | JACC This Week

March 3, 2026: Hypertrophic Cardiomyopathy in Focus—MAPLE-HCM Trial, Myosin Inhibitors & What Improvement Really Means | JACC This Week

In this episode of JACC This Week, Dr. Carolyn Lam and Dr. Harlan Krumholz spotlight a mini-focus issue on hypertrophic cardiomyopathy (HCM), a field undergoing rapid transformation. The discussion ce...

3 Mars 18min

February 24, 2026: ACHD Guideline in Focus—From Survival to Stewardship | JACC This Week

February 24, 2026: ACHD Guideline in Focus—From Survival to Stewardship | JACC This Week

In this episode of JACC This Week, Dr. Carolyn Lam and Dr. Harlan Krumholz spotlight the 2025 Adult Congenital Heart Disease (ACHD) Guidelines and explore what they signal for the future of cardiovasc...

24 Feb 13min

JACC This Week Bonus Episode – Women's Cardiovascular Health: From Inclusion to Redesign

JACC This Week Bonus Episode – Women's Cardiovascular Health: From Inclusion to Redesign

This bonus episode continues the conversation from the JACC Women's Cardiovascular Health Issue, moving from science to systems. In this extended discussion, Drs. Carolyn Lam and Harlan Krumholz are j...

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