The Methylene Blue Episode | Solo Biohacking Masterclass  : 1366

The Methylene Blue Episode | Solo Biohacking Masterclass : 1366

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption.


Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork.


You’ll Learn:

• Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood

• The exact signs that your dose is too strong, too weak, or in the Goldilocks zone

• How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience

• Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions

• How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters

• The link between mitochondrial health, fertility, libido, and long term anti aging strategies

• How to track sleep optimization, HRV, and performance signals to dial in your personal protocol

• The difference between aquarium grade dye and pharmaceutical grade formulations

• Why genetic testing for G6PD deficiency is essential before higher dose experimentation


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair


Thank you to our sponsors!

-BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.


Resources:

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

4:51 — History of methylene blue

7:38 — How methylene blue works

14:05 — Safety

17:53 — Dosing and timing guidelines

20:41 — Combining with red light therapy

22:41 — Quality and sourcing

23:17 — Dosing protocols

25:24 — Longevity and fertility effects

29:24 — Stacking options

32:10 — Common questions and FAQs

33:40 — Future research and wrap up

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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#98 Transforming Lives with Light and Helen Irlen

#98 Transforming Lives with Light and Helen Irlen

Any Hollywood movie star will tell you that lighting is ‘everything’ when it comes to looking great and performing well. But lighting is so much more than just looking good on camera – it affects your mental performance in a major way. Today’s podcast guest, Helen Irlen, is dedicated to getting the word out about visual health and how to optimize your performance by identifying your particular lighting requirements. On the show Helen talks about the Irlen Method and why the science of color transforms lives! Ever wonder what those funny-looking glasses are that Dave wears all the time? Discover what they are and why he wears them on this episode of Bulletproof Radio!     Helen L. Irlen is an internationally recognized educator, researcher, therapist, scholar, and expert in the area of visual-perceptual problems. She is a graduate of Cornell University. Ms. Irlen has been in the field of education for the past 40 years. Her background includes 15 years as a School Psychologist, 30 years as a Child and Family Therapist, Educational Therapist, founder and director of the Adult Learning Disabilities Program and Assistant Professor of Adult Learning Disabilities at California State University/Long Beach, instructor in psychology at Cornell University, and research assistant at Cornell. Because of this breakthrough, the Irlen Method has been the subject of two segments of 60 Minutes, Good Morning America, The Home Show, 60 Minutes Australia, a BBC Special, ABC Worldwide News with Peter Jennings, NBC News, and numerous TV shows around the world.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Feb 201444min

#97 Biohacking Your Impact with Anese Cavanaugh

#97 Biohacking Your Impact with Anese Cavanaugh

When was the last time you were consciously aware of how others perceive you in the world? Take a second and consider how biohacking your impact can improve performance. It’s not all tie-die and patchouli (although we love tie-die and patchouli), this stuff is based in science and it works. IEP Method creator, Anese Cavanaugh, comes on Bulletproof Radio to talk intentional energetic presence, and why not to be a professional bummer. You’ll discover the science behind IEP and how to boost your energetic presence. You’ll also learn why a great reason for having good hygiene. Dig in and be present!     Anese Cavanaugh is a mom, entrepreneur, writer, speaker, and all-around leadership and collaboration expert. She is the creator of the IEP Method and Craft Impact Program. Anese is considered a trusted advisor, teacher, and thinking partner to some of today’s most savvy business leaders and organizations like IDEO, Cooper, Chevron, IBM, Doorsteps, Citicorp, and others. Anese has been seen in Shape Magazine, Prevention Magazine, the Miami Herald, Western Suburban, TNG, Leadership Digital, Inc Small Giants, and on stages across the country. She swears by self-care, purpose, and impact; is obsessed with Bikram Yoga, cross training, and Bulletproof Coffee; delights in partnership and being a mom to 2, and currently splits her time between San Francisco, New York City, and Sacramento. You can tweet her at @anesecavanaugh. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Feb 201454min

#96 The Trivium Method & Transhumanism with Jan Irvin

#96 The Trivium Method & Transhumanism with Jan Irvin

“Most of what people know is BS.” Jan Irvin of Gnostic Media joins Bulletproof Radio to talk The Trivium Method and Transhumanism – amongst other things. To say that Jan constitutes a wealth of information would be a gross understatement. Well known for fact checking and principled verification, Irvin shares his insights on critical thinking, common sense, and psychedelics. Enjoy!     Jan Irvin is an independent researcher, author, and lecturer. He hosts the popular Gnostic Media podcast, and has done much to expose ongoing CIA programs, such as Operation MKULTRA – the reality of which is only now coming to light – 40 years on. Jan has done over 200 radio interviews (on other programs), has been featured in several documentaries, and has produced many documentaries and videos himself.  He also authored the book The Holy Mushroom: Evidence of Mushrooms in Judeo-Christianity; A critical re-evaluation of the schism between John M. Allegro and R. Gordon Wasson over the theory on the entheogenic origins of Christianity presented in The Sacred Mushroom and the Cross, 2008.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Feb 201457min

#95 Hacking Your PH, LED lighting, & Smart Drugs with Steven Fowkes Part 2

#95 Hacking Your PH, LED lighting, & Smart Drugs with Steven Fowkes Part 2

Let there be light! But not just any light, red and blue LED light to be specific. On part 2 of Bulletproof Radio’s Steve Fowkes series, an in-depth conversation from this biohacking master continues. You will hear Steve and Dave talk about the benefits of light for mitochondrial function and how using certain types of light therapy can help you kick more ass. Oh! There is a ton of talk about smart drugs too. Discover new ways to upgrade your mind with racetams from the man who literally wrote the book on nootropics before they were even called that… And don’t forget to listen to part 1!     Steven Wm. Fowkes is an organic chemist by degree and a scientific generalist by nature.  He is author or co-author of six books, five of which are health related, and has published over 100 issues of two health newsletters.  He has been hacking health for four decades in many novel ways, long before self-care and Quantified Self became popular ideas.  One hack was overcoming severe stage fright, which enables Steve to do public-speaking engagements (see him at last year's Bullet-Proof Conference) and TV appearances (including his15-minutes-of-fame on Larry King Live). Google him!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Feb 201452min

#94 Hacking Your PH, LED lighting, & Smart Drugs with Steven Fowkes Part 1

#94 Hacking Your PH, LED lighting, & Smart Drugs with Steven Fowkes Part 1

We have all heard of “pH,” but do you actually know what it is or how to measure it in your body? In this very special episode of Bulletproof Radio, Steve Fowkes is on the show in part 1 of a two-part series with one of Dave’s mentors and heavy-hitting science experts. Steve’s sophisticated understanding of pH mechanisms of health go far beyond the simplistic "alkalinize, alkalinize, alkalinize" message that most people hear. You’ll discover how to hack your own pH and circadian rhythm and why doing so is essential to increasing your performance. Grab a pen and enjoy. And don’t forget to listen to part 2 later this week!   Steven Wm. Fowkes is an organic chemist by degree and a scientific generalist by nature.  He is author/co-author of six books, five of which are health related, and has published over 100 issues of two health newsletters.  He has been hacking health for four decades in many novel ways, long before self-care and Quantified Self became popular ideas.  One hack was overcoming severe stage fright, which enables Steve to do public speaking engagements (see him at last year's Bulletproof Conference) and TV appearances (including his 15 minutes of fame on Larry King Live). Google him!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Feb 201449min

#93 Primal Movements with BJ Baker

#93 Primal Movements with BJ Baker

BJ Baker was the first strength and conditioning trainer for the Boston Red Sox and has been involved in the training, preparation, nutritional counseling, and rehabilitation of athletes in virtually every sport. BJ is currently the Head Athletic Trainer at Pure Performance Training and comes on Bulletproof Radio to talk about his experience as a top-level pro in functional movement and physical therapy. You’ll discover why he’s a fan of ‘primal movement,’ the difference between training pro-athletes vs. an average Joe, and what the shortest route to optimal is.   BJ Baker has been involved in the training, preparation, nutritional counseling, and rehabilitation of athletes in virtually every sport. He earned a Bachelor of Science in Physical Education/Athletic Training (Magna Cum Laude) at Cortland State University before going on to complete his Master’s Degree in Exercise Science with a concentration in Sports Medicine from Ithaca College. BJ has served on the Athletic Training staff at Cornell University, Harvard University and was the first Conditioning Coordinator for the Boston Red Sox. He has been married to his wife Laura for 27 years and has two children. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Jan 201455min

#92 Creating Digital Happiness with Anna Akbari – Podcast

#92 Creating Digital Happiness with Anna Akbari – Podcast

When is the last time you thought about your relationship to technology? It is certainly something to consider these days. On this episode of Bulletproof Radio, digital happiness hacker and identity construction expert, Anna Akbari, enlightens us on the sociology of style and how it can help you perform better. You’ll hear about hacking your own identity, the evolution of cultural perception, and how to create closet catharsis. Oh! And ever wondered what beards say about people? You’ll hear something about that too! This is a great show on a holistic approach to individual empowerment. Enjoy! Anna Akbari, Ph.D., is a sociologist and serial entrepreneur. She taught in the department of Media, Culture, and Communication at New York University and at Parsons The New School for Design. Her research focuses on technology/human relationships, digital happiness, and strategic visual and virtual self-presentation and identity construction (including sartorial semiotics and techniques of the body). Akbari is the founder of Sociology of Style, which blends social science with pop culture analysis and practical advice to offer smart, timely commentary on image-related issues and culture. She is also the founder of Sociology of Style Services, her image consulting company, which addresses identity construction through personal styling, image management, and bodily manipulation. Watch her TED talk on "Digital Happiness.” She currently works and lives between San Francisco and New York City. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Jan 201456min

#91 Hacking Happiness with Stella Grizont

#91 Hacking Happiness with Stella Grizont

Woopaah! It turns out that happiness really can make or break your performance. On this episode of Bulletproof Radio one of the world’s best and first positive psychologists, Stella Grizont, talks about the science of happiness. And don’t worry! It’s not all puppies and unicorns – although who doesn’t like unicorns? Hear the ‘set point’ theory of happiness, the negativity bias, and even how to hack your way out of a shitty day. Dave even opens up about his most boring job! Oh and didn’t you know? It looks like you can die of a broken heat AND of boredom. Listen up!   Stella Grizont is the founder of WOOPAAH, a company that creates immersive play experiences for people at work to feel happier, more creative, and connected. Some of her clients include Google, Columbia University, and New York City's Department of Transportation. Stella was one of the first 200 people to earn a Masters in Applied Positive Psychology from the University of Pennsylvania. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Jan 201449min

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