The Methylene Blue Episode | Solo Biohacking Masterclass  : 1366

The Methylene Blue Episode | Solo Biohacking Masterclass : 1366

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption.


Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork.


You’ll Learn:

• Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood

• The exact signs that your dose is too strong, too weak, or in the Goldilocks zone

• How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience

• Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions

• How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters

• The link between mitochondrial health, fertility, libido, and long term anti aging strategies

• How to track sleep optimization, HRV, and performance signals to dial in your personal protocol

• The difference between aquarium grade dye and pharmaceutical grade formulations

• Why genetic testing for G6PD deficiency is essential before higher dose experimentation


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair


Thank you to our sponsors!

-BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.


Resources:

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

4:51 — History of methylene blue

7:38 — How methylene blue works

14:05 — Safety

17:53 — Dosing and timing guidelines

20:41 — Combining with red light therapy

22:41 — Quality and sourcing

23:17 — Dosing protocols

25:24 — Longevity and fertility effects

29:24 — Stacking options

32:10 — Common questions and FAQs

33:40 — Future research and wrap up

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Upgrade Spotlight: Redefining Wellness with Topical Glutathione: A Health Revolution with Nayan Patel , PharmD  : 1056

Upgrade Spotlight: Redefining Wellness with Topical Glutathione: A Health Revolution with Nayan Patel , PharmD : 1056

Nayan Patel, PharmD recently published his first comprehensive book, “The Glutathione Revolution: Fight Disease, Slow Aging & Increase Energy.” After 14 years of clinical research on the master antioxidant, glutathione, Dr. Patel finally shares how powerful and essential glutathione is to the body’s detox system. He speaks about the various benefits it has with slowing the aging process down, and explains how you can increase your levels naturally. Dr. Patel is a firm believer in providing the body with tools it needs to defend itself and promote a healthy lifestyle that fits the pace of the modern world. Nayan Patel, Pharm.D is globally regarded as the foremost go-to expert on absorbable forms of glutathione, and holds the only patent on transdermal glutathione.Along with traveling the world educating practitioners on advanced biochemistry and anti-aging science, Dr. Patel also serves as adjunct faculty at the University Of Southern California School Of Pharmacy where he is also an alumnus.9th Annual Biohacking Conference: You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life. https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Juni 202330min

Upgrade Spotlight: Unlocking the Secrets of Water Energy, Frequency & Vibration - Mario Brainovic : 1055

Upgrade Spotlight: Unlocking the Secrets of Water Energy, Frequency & Vibration - Mario Brainovic : 1055

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25 Maj 202355min

The Secrets to Creating Your Own Happy, Healthy Life - Jason Wachob : 1054

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Unlock Your Limitless Potential & Unleash Your Inner Peace - Genpo Roshi : 1053

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Redefine Your Reality & Unveil the Secrets of Your Conscious Mind - Philip Goff & Anil Seth : 1052

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18 Maj 202349min

Unlocking Optimal Health & Conscious Endings - Interventions With Dave - Nancy Sheeber : 1051

Unlocking Optimal Health & Conscious Endings - Interventions With Dave - Nancy Sheeber : 1051

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16 Maj 202335min

Strength Training Upgrade: Transform Your Body & Mind - Frank Zane & Ben Pakulski : 1050

Strength Training Upgrade: Transform Your Body & Mind - Frank Zane & Ben Pakulski : 1050

Unravel the insights and wisdom shared by two legendary guests: Mr. Olympia Frank Zane and renowned strength expert Ben Pakulski.Frank Zane is an American former professional bodybuilder, author, and coach who has left a lasting impact on the fitness world. With a focus on symmetry and proportion, Frank's physique earned him three Mr. Olympia titles and the nickname King of Aesthetics. Today, at 75 years old, he continues to offer personal coaching, training programs, and seminars to share his vast knowledge of bodybuilding and fitness.Ben Pakulski, a recently retired professional bodybuilder and former Mr. Canada. Ben is on a mission to educate people globally on a holistic approach to muscle building, empowering them to change both their body and mind.Throughout this combined episode, we explore the shared principles that underpin these two remarkable journeys. From the importance of discipline, focus, and perseverance to the significance of customized nutrition and training plans, our guests leave no stone unturned in their quest to unlock human potential.Check out this enlightening and transformative exploration of the science of the perfect physique and the reimagining of strength training, guided by the wisdom of Frank Zane and Ben Pakulski.Prepare to unlock your true potential and unleash the power within.Find all the links and resources in the show notes.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Anti-aging Powerhouse: https://spermidinelife.us/dave , use code DAVE25 to save 25% on your first purchase9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida. https://biohackingconference.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Maj 202340min

10 Vital Moves to Reach Your Body's Full Potential – Kelly Starrett : 1049

10 Vital Moves to Reach Your Body's Full Potential – Kelly Starrett : 1049

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