10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


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Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Gerard Mullin: Gut Balance Revolution, Ketosis, & Artificial Sweeteners - #253

Gerard Mullin: Gut Balance Revolution, Ketosis, & Artificial Sweeteners - #253

Gerard Mullin comes on Bulletproof Radio today discuss his new book, The Gut Balance Revolution. As well his thoughts on detox fads, his favorite "superfoods," and how you can start hacking gut bacteria. Dr. Mullin is an associate professor of medicine at The Johns Hopkins Hospital. He is board-certified in internal medicine, gastroenterology, integrative medicine, functional medicine and nutrition. Nationally and internationally renowned for his work in integrative gastroenterology and nutrition, Dr. Mullin has more than 20 years of clinical experience in the field of integrative gastroenterology and earned his master's degree in nutrition while in practice. He is an associate editor of several nutrition and integrative medicine journals. Dr. Mullin was selected by Dr. Andrew Weil to serve as a senior editor for the first book for physicians on integrative gastroenterology by Oxford Press, which was released in May of 2011. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Okt 201556min

Blue Zones: How to live longer and happier lives w/ Dan Burden - #252

Blue Zones: How to live longer and happier lives w/ Dan Burden - #252

Dan Burden and Samantha Thomas come on Bulletproof Radio today to discuss the Blue Zones project, a project that focuses on enabling cities to develop strong, healthy communities and how they have already upgraded longevity across the country. Dan Burden, the Director of Innovation and Inspiration for Blue Zones, LLC, has focused his entire career on helping the world get back on its feet. Dan created the walking audit; a highly interactive way to help people see their community through a sharper, more people focused lens. This popular annual NPSG walking audit workshop is designed to help participants fine-tune their most engaging public interaction skills. Dan illustrates the benefits of sometimes-simple and oft-difficult changes, and provides a roadmap for people to create neighborhoods, streets and cities that are more healthy and better connected. Samantha helps communities-neighborhoods, towns and cities-become healthier, better connected, more accessible and age-friendly. Over the last four years, Samantha has worked in over 100 cities, facilitating walkability, active-living and safe routes to school workshops and developing community-led action plans for communities. She brings to this effort a diversity of experience in community engagement, the power of neighborhood leadership, and civic co-creation from living and working in South Africa for a year, to two years as AmeriCorps volunteer with Amherst H. Wilder Foundation and the City of Saint Paul Office of the Mayor. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Okt 201556min

Summer Bock: Can Fermented Foods Restore Your Gut? - #251

Summer Bock: Can Fermented Foods Restore Your Gut? - #251

Summer Bock comes on Bulletproof Radio today discuss her treatment for food allergies, what a "fermentationist" is, how you can cultivate healthy gut bacteria, and the best foods to eat for gut health. Summer Bock is a Master Fermentationist who guides people to experience a deeper level of healing. Her mission is to radically improve people's health while empowering them to revolutionize the local food system using delicious, local and healthy food. A skilled herbalist with a background in microbiology, she is certified by the Institute of Integrative Nutrition and Columbia University. Summer has created an avid following with her signature programs The Probiotic Power Cleanse, Gut Rebuilding, and the yearlong Fermentationist Certification Program. Enjoy the Show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Okt 201557min

Dr. David Perlmutter: Autism, Alzheimer's & The Gut Microbiome - #250

Dr. David Perlmutter: Autism, Alzheimer's & The Gut Microbiome - #250

Dr. David Perlmutter comes on Bulletproof Radio today discuss the gut microbiome, it's relation to autism and Alzheimer's, prebiotics you should be taking, and the importance of a balanced gut. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Okt 20151h 14min

Jeff Chilton: Medicinal Mushrooms & Industrial Mushroom Cultivation - #249

Jeff Chilton: Medicinal Mushrooms & Industrial Mushroom Cultivation - #249

Jeff Chilton comes on Bulletproof Radio today to discuss medicinal mushrooms, mushroom industry flaws, understanding mushroom spores, and vitamin D in mushrooms. Jeff Chilton has been in the mushroom industry since 1973. He is a founding member of the World Society for Mushroom Biology and Mushroom Products and a member of the International Society for Mushroom Science. Jeff Chilton's company, Nammex, was the first company to offer certified organic mushrooms to the supplement industry in the United States. Nammex extracts are used by many supplement companies and are considered high quality based on scientific analysis of the active compounds. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Okt 201549min

Nadine Artemis: Holistic Dentistry, Root Canal Dangers & Benefits of Essential Oils - #248

Nadine Artemis: Holistic Dentistry, Root Canal Dangers & Benefits of Essential Oils - #248

Nadine Artemis and comes on Bulletproof Radio today to discuss her approach to dentistry, how to whiten teeth naturally, anti-aging in the sun, and why you should avoid fluoride. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Sep 201552min

Tom O'Bryan and Daniel Moriarty: Hacking Adaptogens - #247

Tom O'Bryan and Daniel Moriarty: Hacking Adaptogens - #247

Tom O'Bryan and Daniel Moriarty come on Bulletproof Radio today to discuss the power of adaptogenic herbs, the science behind adaptogens and how they affect your biology, energy, and overall well-being. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Sep 20151h 5min

Suzanne Somers: Toxic Mold, Breast Cancer & C-section Risks - #246

Suzanne Somers: Toxic Mold, Breast Cancer & C-section Risks - #246

Suzanne Somer comes on Bulletproof Radio today to discuss her experience living with toxic mold, how progesterone helps fight cancer, and the dangers of smart meters on our health. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Sep 201535min

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