10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Avsnitt(1423)

#47 Biohacking Cows, Bulletproof Dairy and Probiotics with Natural Health Expert, Jordan Rubin

#47 Biohacking Cows, Bulletproof Dairy and Probiotics with Natural Health Expert, Jordan Rubin

Jordan Rubin is one of America’s most recognized and respected natural health experts. He is the author of the New York Times best selling book, The Maker’s Diet, as well as the author of 19 other health related titles, including his latest work Perfect Weight America. An international motivational speaker, Jordan hosts the weekly television show Extraordinary Health that reaches more than 30 million households worldwide. He is Founder and CEO of Garden of Life, a leading health and wellness company committed to empowering extraordinary health with whole food based supplements, functional foods, and founder of Beyond Organic. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Juni 201349min

#46: Reichart Von Wolfsheild - Bulletproof Your Systems

#46: Reichart Von Wolfsheild - Bulletproof Your Systems

Reichart Von Wolfsheild, is a co-host on History Channel’s Invention USA.  He is a technologist, inventor, artist and futurist. Starting in his teens, he designed and built a computer CPU from scratch. In the early 1980s, while helping pioneer music videos for the then-fledgling network, MTV, he started his first successful technology company developing Artificial Intelligence applications. Blending his talents from several fields he made history conceiving one of the first multi-player modem video games, kicking off a franchise. He has designed everything from toys to weapons and developed more than 120 products for companies such as Boeing, Disney, Dreamworks and Mattel, and is always looking for the next fun challenge. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Juni 201346min

#45: Q & A More on Coffee, Kale, & Adrenal Fatigue

#45: Q & A More on Coffee, Kale, & Adrenal Fatigue

Questions Asked in the Podcast:   1:20 What is the best way to store Bulletproof Coffee and can you pre-grind it and store it? 4:10 For people who like to do heavy workouts several times a week what do you recommend for  recovery and muscle building? 5:30 What's the deal with drugs, specifically marijuana? Is it Bulletproof? 7:14 What about marijuana by products like Hemp protein powder or Hemp seed oil? 8:44 How can I get a Bulletproof T-shirt like the one Dave had on the Joe Rogan Experience? (bulletproofexec.com/shirts) 10:01 What are the differences between the new Bulletproof Upgraded Brain Octane Oil and the Bulletproof MCT Oil? Does the Octane Oil replace the MCT Oil or is it mean to be an addition? 13:10 Can I add the Upgraded Whey into my coffee without pushing myself out of ketogenesis? 14:28 Why is there no Certified Organic label on the MCT Oil? 15:10 How do you make a proper iced ,and blended iced, Bulletproof coffee without the fat sticking to the sides or globbing together? 16:22 Is taking Bioidentical growth hormone safe? 17:34 In the Kale Shake you list raw eggs as a potential addition, would eggshells work as well? 18:49 I massage my kale before blending or sauteing it, do I still need to stew this before steaming, or should I just cut the massage out altogether? Also are the oxalates in baby kale less? 19:43 Should I make a kale shake in addition to or in lieu of Bulletproof coffee? 20:35 Are kale chips Bulletproof? 22:19 Why is Bulletproof Coffee NOT affected by the coffee fungus problem? 24:21 Changing your diet making you stinky? 26:40 Activated charcoal and its benefits 30:24 How do I recover if I have a cheat meal from the Bulletproof Diet? 32:03 How to schedule Bulletproof Coffee and Diet around a crazy sleep schedule 35:30 Can I substitute kale with broccoli to avoid the toxins? 35:50 Adrenal Fatigue, how do you know you have it, what are some common causes, and how do I make it better? 39:35 How do you gain weight while Bulletproof? 42:35 Biohacks of the week and other conversation...   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Juni 201349min

Bonus: Client Review with Jonathan Kos

Bonus: Client Review with Jonathan Kos

Jonathan Kos is an IT professional and a recent follower of the Bulletproof Diet.  He is a 44 year old IT professional . At 6' 3" and a former college athlete that played football, competitive ice hockey up until the age of 25 he was an extremely fit 220 lbs and my coaches wanted me up to 275 or so to play the defensive line so I was eating literally non stop to put weight on. After college he dropped down to around 200 lbs and eventually settled at for me was a healthy 235.  As he got older and more settled in his job, his weight climbed and he couldn’t keep his weight in check with exercise alone and he started to have to diet he was up to 300 lbs and was exercising more that ever but the weight didn’t come off. After he met his wife, exercise was out the window, a carb heavy diet was in, and his weight ballooned up to 365lbs. He was about to give up until he heard Tait Fletcher on Joe Rogan's podcast mentioning Bulletproof ® Coffee and he gave it a shot. He lost 45lbs in 45 days, and is here to share his experience with you.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Juni 201311min

#44: Salt and self-experimentation with Greg Pomerantz

#44: Salt and self-experimentation with Greg Pomerantz

For Greg Pomerantz everything is a science experiment. He takes citizen science to a personal level by biohacking his blood pressure and detailing his data. He blogged about his self-experiment research on salt clarifying some concerns he had about salt’s effect on the body. He determined what his salt type is, either one is salt sensitive, or one that isn’t affected much by increases in salt. He discusses how to do that in today’s podcast. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Juni 201337min

#43: Kelly Starrett, Mobility and Performance

#43: Kelly Starrett, Mobility and Performance

Coach Kelly Starrett received his Doctor of Physical Therapy in 2007 from Samuel Merritt College in Oakland, California. He currently runs his own physical therapy practice at San Francisco CrossFit—one of the first 50 CrossFit affiliates—and focuses on performance-based Orthopedic Sports Medicine with an emphasis on returning athletes to elite level sport and performance. His clients see exceptional results from his progressive blend of manual physical therapy and strength training. Since 2009, Kelly has been traveling the country teaching his "Movement, Mobility & Maintenance Course" in an effort to spread his message that good mobility and proper movement are the keys to good performance and that all humans should be able to perform this basic maintenance on themselves. Kelly's clients have included Olympic gold-medalists, Tour de France cyclists, world-class extreme skiers and X-Games medalists, dancers with Smuin, San Francisco, and Sacramento Ballet Companies, military personnel, and competitive age-division athletes. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Maj 201350min

#42: Alderspring's Glenn Elzinga, Grass-Fed Beef and a Bulletproof Protein

#42: Alderspring's Glenn Elzinga, Grass-Fed Beef and a Bulletproof Protein

With training in forestry and forest ecology, Glenn Elzinga began his forestry career in Maine. In the mid 1980s, he moved to Salmon, Idaho where he worked as District Forester for the Salmon BLM for over a decade. As his family began to grow, he realized he wanted a better way to raise kids than leaving them for work all day. So began his current career in ranching. After ranching for 17 years, Glenn's cattle herd has grown from 7 head to over 600. He keeps his hand in forestry by working with his wife, Caryl, on consulting projects and by horse-logging occasionally with his two Belgian mares, Pet and Pat. He hopes to train his new draft Suffolk geldings, Red and Snap, to log as well. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Maj 201350min

#41: Jason Nunnelley, Self Tracking

#41: Jason Nunnelley, Self Tracking

Jason Nunnelley’s work is focused on application and systems development. After his first company sold in 2000, he spent his time helping small business capitalize on Internet technologies. He is presently dedicated to dosIQ, Inc., a Wellness Journal and set of apps designed to make self-tracking and health monitoring simple for anyone. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Apr 201358min

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