How Foundation Models Evolved: A PhD Journey Through AI's Breakthrough Era
The Stanford PhD who built DSPy thought he was just creating better prompts—until he realized he'd accidentally invented a new paradigm that makes LLMs actually programmable. While everyone obsesses o...
18 Nov 202557min
TruffleHog Creator: You Can’t Have AI Agents Without Secrets
If you can’t robustly protect your secrets, you can’t have reliable AI agents.In this episode, Truffle Security cofounder and CEO Dylan Ayrey joins a16z partner Joel de la Garza to discuss the emergen...
11 Nov 202528min
Tigris Data CEO on Building Your Own Datacenters
In this episode, a16z General Partner Martin Casado sits down with Ovais Tariq, Cofounder and CEO of Tigris Data, to discuss why independent storage is so hard, what operating your own datacenters is ...
7 Nov 202538min
Pylon: Reimagining B2B Customer Support
Customer support platforms lacked adequate solutions for B2B companies - until Pylon entered the scene.We sat down with Pylon cofounders Marty Kausas, Advith Chelikani, and Robert Eng to discuss why t...
31 Okt 202547min
Keycard: 2026 is the Year of Agents
In 2025, we saw the first glimpses of true AI agents. In 2026, every company will be rushing to get them into production, and they’ll need companies like Keycard to manage fleets of agents.In this con...
22 Okt 202532min
The Trillion Dollar AI Software Development Stack
AI coding has emerged as a major market for AI: one that’s already rewriting how software gets built.a16z Infra Partners Yoko Li and Guido Appenzeller break down how “agents with environments” are cha...
10 Okt 202538min
Material Security CEO: How To Find Your Ideal Customer
What if the hardest part of building a company isn’t the product, but knowing exactly who it’s for?In this episode, a16z General Partner Martin Casado sits down with Abhishek Agrawal, Cofounder and CE...
6 Okt 202534min
When Deepfakes Steal $30M: The New Edge of Cybercrime
AI is transforming both sides of the cybersecurity cat-and-mouse game. Attackers are using LLMs to scale impersonation, phishing, and even deepfake fraud—while defenders are racing to automate detecti...
26 Sep 202522min
