366: BRCA1P1 suppresses antiviral and antitumor immunity
Han YJ et al., Proceedings of the National Academy of Sciences (PNAS) - This episode examines a PNAS study showing that the BRCA1 pseudogene BRCA1P1 produces circular RNAs that suppress antiviral inna...
15 Maj 24min
365: MEN1 mutations and menin inhibitor resistance
Bourgeois et al., Nature Communications - This study used enhanced CRISPR base editor screens, structural biology, biochemical assays, and in vitro/in vivo selection to map MEN1 mutations that drive r...
15 Maj 22min
364: Peripheral C4 and Schizophrenia: A Neutrophil Gene–Protein Link
Kalinowski A et al., PNAS - This study reports that C4 protein is enriched in human neutrophils and monocytes and that neutrophil C4 protein levels correlate with C4A gene copy number specifically in ...
11 Maj 17min
363: cfDNA size deconvolution reveals a 159‑bp nucleosomal pivot and tumor fragmentomic signatures
Zhou Z et al., Nature Communications - This study develops a Lorentzian deconvolution model of cfDNA fragment length distributions across bodily fluids, identifies a ~159 bp component that demarcates ...
9 Maj 22min
362: D614G Reshapes Spike Allostery and Speeds RBD Opening
Kearns FL et al., PNAS - Simulations and HDXMS reveal how the D614G substitution alters internal communication in SARS-CoV-2 spike, enabling faster receptor-binding-domain opening through newly engage...
9 Maj 18min
361: Chiral Inversion Mutagenesis Reveals Structured Hotspots in LCDs
Beckner RL et al., PNAS - This episode examines a PNAS study using Chiral Inversion Mutagenesis (ChIM) to scan low-complexity domains (LCDs) of Emerin and neurofilament light chain (NEFL). Targeted L-...
8 Maj 24min
360: An inverse correlation between structural linguistic and human genetic diversity
Graff A et al., PNAS - A PNAS study linking global population-genetic data and structural linguistic features finds an inverse correlation: regions with lower genetic diversity show higher structural ...
7 Maj 26min
359: Ultrapotent PDCoV Miniprotein MB11
Avery NG et al., PNAS - This episode covers a PNAS study reporting the de novo design of miniprotein inhibitors targeting porcine deltacoronavirus (PDCoV). The lead minibinder, MB11, binds the PDCoV R...
6 Maj 23min
