273: CTVT-A acquires 15-Mb N-HT1 dicentric nuclear element via horizontal transfer
Gori K et al., Proc. Natl. Acad. Sci. U.S.A. 2025.122:e2424634122 - In canine transmissible venereal tumor (CTVT), deep sequencing and cytogenetics identify a 15‑Mb horizontally transferred nuclear el...
28 Jan 18min
272: ADSL A429V reduces purine biosynthesis in brain and alters female mouse water-seeking behavior
Ju X-C et al., Proc. Natl. Acad. Sci. U.S.A. 2025.122:e2508540122 - Human-specific ADSL A429V substitution and a common regulatory haplotype reduce ADSL activity and raise purine substrates in the bra...
27 Jan 22min
271: Rising EA PGI prediction of educational attainment across 1946–1970 British birth cohorts and socioeconomic interaction
Morris TT et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2516460123 - EA and cognition polygenic indexes (PGIs) in three British birth cohorts show EA PGI associations with years of education increas...
25 Jan 19min
270: Human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes negatively supercoiled DNA measured by optical tweezers
Spakmana D et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2406949123 - Optical tweezers and fluorescence imaging show human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes highly negatively s...
25 Jan 22min
269: Mlh1–Pms1 endonuclease creates single-strand gaps to excise mispairs in S. cerevisiae MMR
Palacio T et al., Proc. Natl. Acad. Sci. U.S.A. 2025.122:e2528670122 - Reconstituted Saccharomyces cerevisiae mismatch repair shows the Mlh1–Pms1 endonuclease directly generates single-strand gaps to ...
24 Jan 20min
268: M493I in human β-cardiac myosin: SRX disruption, slow ADP release, and enhanced actin attachment
Cail RC et al., Proc. Natl. Acad. Sci. U.S.A. 2025.122:e2521561122 - Recombinant human β-cardiac myosin M493I studied by optical trapping and stopped-flow kinetics disrupts the super-relaxed state and...
23 Jan 22min
267: DNA base-pair opening modes and soliton-like loops revealed by hydrogen exchange
Englander SW et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2520855122 - Hydrogen exchange (H-T and NMR H-H) on DNA and RNA reveals two distinct base-pair opening modes: single-base microsecond openi...
22 Jan 21min
266: TOP1α and TOP3β Differentially Regulate HPV31 Replication via R-loops and DNA Breaks
Vatsa A et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2526296123 - In HPV31-positive keratinocytes (CIN612), TOP1α and TOP3β are upregulated and required for viral transcription and replication, act...
21 Jan 17min
