257: PSMC5: proteasomes, immunity and neurodevelopment
Küry S et al., Nature Communications, doi:10.1038/s41467-025-65556-8 - This study describes 26 distinct PSMC5 variants in 44 individuals and demonstrates that PSMC5 loss impairs proteasome function, d...
12 Jan 18min
256: Compartmental control of VSG silencing
Antunes et al., Nature Communications - The study shows that spatial segregation of core and subtelomeric chromosome compartments, demarcated by protein-rich boundaries and controlled by a phosphoinos...
11 Jan 18min
255: Lipids, Ions and the AE1 Elevator
Chen T et al., Nature Communications - Cryo-EM structures, uptake assays, and molecular dynamics show that PIP2 lipids bind at the AE1 dimer interface and inhibit the OF⇌IF conformational transition w...
10 Jan 19min
254: Rescuing the replisome at a nick
Winterhalter et al., Nature Communications - Cas9 nickases in Bacillus subtilis show that single-strand nicks in either template strand arrest DNA replication, create single-end double-strand breaks, ...
9 Jan 19min
253: Nap1 and histone acetylation tune chromatin condensates
Gao J et al., Nature Communications - H4 tail lysine residues drive liquid-liquid phase separation of 12‑mer nucleosome arrays, while H3 tail acetylation and the histone chaperone Nap1 increase intern...
8 Jan 20min
252: Keratinocytes to cSCC: genetic steps
Deivendran D et al., Nature Communications, doi:10.1038/s41467-025-65687-y - Single-cell and spatial multi-omic profiling maps the genetic and transcriptional changes from normal keratinocytes through...
7 Jan 18min
251: MuSCs, laminin-α2 and LAMA2 MD
McGowan TJ et al., Nature Communications, doi:10.1038/s41467-025-65703-1 - Activated muscle stem cells express and secrete laminin-α2 to remodel their niche, and loss of MuSC-derived laminin-α2 slows ...
6 Jan 19min
250: CIP2A–TOPBP1: Mitotic repair via MiDAS and MMEJ
Nieminuszczy J et al., Nature Communications, doi:10.1038/s41467-025-65594-2 - This study shows the CIP2A-TOPBP1 complex coordinates two mitotic double-strand break repair pathways, MiDAS and MMEJ, by...
5 Jan 18min
