193: SARM1, DNA, and the Death Signal
️Episode 193: SARM1, DNA, and the Death Signal In this episode of PaperCast Base by Base, we explore how the axon-degenerating enzyme SARM1 acts as a double-stranded DNA sensor that triggers NAD+ loss...
9 Nov 202515min
192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations
️Episode 192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations In this episode of PaperCast Base by Base, we explore how base-pair resolution maps of chromatin contacts reveal a unifi...
8 Nov 202514min
191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI
️ Episode 191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI In this episode of PaperCast Base by Base, we explore a Nature Communications study that proposes CATphis...
7 Nov 202519min
190: dGCNA and single-cell maps reveal cell-type mechanisms in T2D
Martínez‑López JA et al et al., Nature Communications - This episode examines a Nature Communications study that introduces differential Gene Coordination Network Analysis (dGCNA) applied to deep Smar...
6 Nov 202515min
189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms
️ Episode 189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms In this episode of PaperCast Base by Base, we explore how genome-wide DNA methylation profiling can p...
5 Nov 202514min
188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis
️ Episode 188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis In this episode of PaperCast Base by Base, we explore how large‑scale mass‑spectrometry proteomics of cerebrospinal fl...
4 Nov 202516min
187: Gapped scheduling: CRLX101 + olaparib Phase I trial
Nature Communications (2025) 16:9457 et al., Nature Communications - Phase I dose-escalation trial combining CRLX101 (nanoparticle camptothecin) with olaparib using a 48-hour gapped schedule in 24 pat...
3 Nov 202516min
186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome
️ Episode 186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome In this episode of PaperCast Base by Base, we explore a single‑cell RNA‑seq study of nasal biopsies showing that persist...
2 Nov 202515min
