215: Protein Set Transformer for high-diversity viromics
Martin et al., Nat Commun (2025) - Protein Set Transformer (PST) is a protein-based genome language model that represents genomes as sets of proteins to improve genome and protein representations acro...
1 Dec 202520min
214: PI(4,5)P2 Asymmetry Accelerates FGF2 Secretion
Kaur M et al., Nature Communications - Reconstitution of asymmetric membranes and matched cell experiments show that transbilayer asymmetry of PI(4,5)P2 lowers the energetic barrier for FGF2-driven li...
30 Nov 202518min
213: BRAIN-MAGNET: Functional genomics atlas for non-coding variants
Deng R et al. - BRAIN-MAGNET couples a ChIP-STARR-seq atlas of 148,198 neural regulatory elements with a validated convolutional neural network to predict enhancer activity and prioritize disease-rele...
29 Nov 202520min
212: Zonal control of mutant β-catenin tumorigenesis
Raven A et al. - This study shows that hepatic zonation determines whether mutant β-catenin drives proliferation and liver cancer by forcing differentiation to a non-permissive zone 3 fate or, when re...
28 Nov 202516min
211: Retention Elements in Cancer Cells
Sankar et al. - This episode explores the discovery of genetic elements that promote the retention of extrachromosomal DNA (ecDNA) in cancer cells, enhancing their survival and evolution. Key terms: e...
27 Nov 202519min
210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma
Tumour-Reactive CD8 T Cell Clusters in Human Melanoma Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09754-w License:This episode is based on an open-...
26 Nov 202518min
209: PERT: Prime Editing tRNAs for Nonsense Mutations
PERT: Prime Editing tRNAs for Nonsense Mutations Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09732-2 License:This episode is based on an open-acces...
25 Nov 202516min
208: ZAK, Collided Ribosomes, and the Stress Switch
ZAK, Collided Ribosomes, and the Stress Switch Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09772-8 License:This episode is based on an open-access ...
24 Nov 202515min
