Beyond the Endpoint

Beyond the Endpoint

The Duke Clinical Research Institute is drawing on gold-standard research and real-world evidence to bring you Beyond the Endpoint, a podcast that is demystifying clinical research and healthcare through conversations with renowned clinicians and scientists.

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From Provider to Patient: A Dual Perspective on Colorectal Cancer

From Provider to Patient: A Dual Perspective on Colorectal Cancer

Hosts Emily O’Brien and Manesh Patel sit down with Dr. Ajay Kohli and Dr. Julius Wilder for a dual-perspective conversation on colorectal cancer, where they discuss personal experiences, the importanc...

3 Dec 202538min

Beyond the Headlines: Recap of the 2025 AHA Scientific Sessions

Beyond the Headlines: Recap of the 2025 AHA Scientific Sessions

Recorded at the 2025 American Heart Association Scientific Sessions, hosts Manesh Patel and Emily O'Brien discuss late-breaking cardiovascular research, including gene-editing therapy for cholesterol,...

19 Nov 202520min

Connecting the Dots: The Broader Applications of GLP-1s and Where We’re Headed Next

Connecting the Dots: The Broader Applications of GLP-1s and Where We’re Headed Next

Endocrinologist Jennifer Green discusses how GLP-1 drugs, like Ozempic, evolved from diabetes tools to potential treatments for addiction and heart disease, in this final installment of the obesity se...

4 Nov 202536min

Obesity, GLP-1s, and the Evidence: What the Data Tells Us

Obesity, GLP-1s, and the Evidence: What the Data Tells Us

In this second episode of our obesity series, preventive cardiologist Neha Pagidipati sheds light on the discovery, impact, and uses of GLP-1s, like Ozempic and Mounjaro. Learn about the impact these ...

22 Okt 202531min

It's Not Just the Scale: Supporting Sustainable Change in Obesity Treatment

It's Not Just the Scale: Supporting Sustainable Change in Obesity Treatment

In the first of a three-part series on obesity and GLP-1 medications, our guest Jennifer Norris shares the evolving landscape of obesity treatment. The conversation addresses common misconceptions and...

8 Okt 202532min

Beyond the Headlines: Funding Research, Vaccines, Sleep Health, and AI in Healthcare

Beyond the Headlines: Funding Research, Vaccines, Sleep Health, and AI in Healthcare

The "Beyond the Headlines" series returns with summer healthcare and research news. Hosts Manesh Patel and Emily O'Brien discuss misconceptions about research funding, a Danish study on vaccine safety...

24 Sep 202526min

Understanding Autism: Insights from Research and Practice

Understanding Autism: Insights from Research and Practice

Ushering in the second season of Beyond the Endpoint, Lauren Franz, MBChB, MPH, interim director of the Duke Center for Autism and Brain Development, joins Manesh Patel and Emily O'Brien for an in-dep...

10 Sep 202526min

Playing to Advance Care: A Championship Mindset in Clinical Research

Playing to Advance Care: A Championship Mindset in Clinical Research

What do championship sports teams and successful research institutions have in common? In the season finale of Beyond the Endpoint, Dr. Adrian Hernandez joins hosts Manesh Patel and Emily O’Brien to...

4 Juni 202534min

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