From First Principles

AI, Eyes, and the Sky — From Synthetic Genomes to Restored Vision and Cosmic MysteriesHosted by Lester Nare and Krishna Choudhary, this episode of From First Principles explores three cutting-edge bre...

6 Nov 20252h 3min

Hosted by Lester Nare and Krishna Choudhary, this episode tells the story of Nobel laureate Chen Ning Yang and how his ideas on symmetry and gauge theory transformed modern physics.Summary• Early Year...

31 Okt 20251h 43min

Aloha internet — Lester Nare and Krishna Choudhary return with three extraordinary research stories: portable muon beams, sodium-ion batteries, and the secret to long life.Summary• Lawrence Berkeley’s...

23 Okt 20251h 36min

After a packed week of Nobel Prize coverage, Lester and Krishna look back on how From First Principles began and why they built it as an “ESPN for Science.” They revisit 2025’s Medicine, Physics and C...

15 Okt 20251h 12min

Hosted by Lester Nare and Krishna Choudhary, this one-episode special brings all three 2025 Nobel Prizes in the sciences into a single listen: Medicine (immune tolerance and FOXP3), Physics (macroscop...

9 Okt 20251h 54min

Hosted by Lester Nare and Krishna Choudhary, this two-story, 2.5-hour special sets the table for Nobel Prize Week with deep dives into two recent Nobel-winning domains—gene editing (CRISPR) and gravit...

2 Okt 20252h 36min

Lester Nare and Krishna Choudhary return for Episode 9 of From First Principles, breaking down the latest breakthroughs across AI, physics, biology, and astronomy. From China’s stunning AI leap with D...

23 Sep 20251h 41min

NASA just dropped what they’re calling the strongest evidence yet for biosignatures on Mars, so we spun up an emergency pod. We break down what the rover actually found in Jezero Crater, why geochemic...

16 Sep 20251h 19min