Why NASH Drug Trials Fail: A Thoughtful, Challenging Theory - Ep 34
Send us a text Prof. Dr. Jörn M. Schattenberg joins the Surfers to discuss his recent article in Expert Opinion on Investigational Drugs dissecting recent drug trial failures. Prof. Dr. Jörn M. Schattenberg joins Stephen, Donna, Louise and Roger to discuss his recent article "The Nonalcoholic Steatohepatitis (NASH) drug development graveyard: established hurdles and planning for future successes." The discussion started with lessons from failed trials, focusing on the importance of utilizing...
12 Nov 202053min
Previewing The Digital Liver Meeting (TLMDx from AASLD): Part Two - Ep 33
Send us a text Stephen Harrison, Roger Green and our guest Surfer, Dr. Manal Abdelmalek, identify pivotally important presentations and posters from The Digital Liver Meeting 2020 SurfingNASH continues our AASLD coverage by asking Stephen Harrison, Roger Green, and guest Surfer Dr. Manal Abdelmalek to identify and review abstracts they consider important or uniquely interesting. The abstracts they chose focus on exciting new agents, the emerging role of #artificialintelligence (AI) and machi...
5 Nov 202056min
Previewing The Digital Liver Meeting (TLMDx from AASLD): Part One - Ep 32
Send us a text Louise Campbell, Donna Cryer, and Naim Alkhouri identify pivotally important presentations and posters from The Digital Liver Meeting 2020. SurfingNASH kicks off its AASLD coverage by announcing four of our seven KOL guest Surfers. One of them, Dr. Naim Alkhouri, participates via interview. Naim, Louise Campbell, and Donna Cryer identify abstracts they consider important or uniquely interesting. The abstracts they chose focus on population health (particularly juvenile and ped...
29 Okt 202056min
How Have The Events of 2020 Affected Patient Treatment In The Clinic? Ep 31
Send us a text Guest Surfer and regular listener Dr. Ian Rowe joins the Surfers to discuss how everyday patient treatment in the clinic once was and how COVID-19 and the news we discuss weekly on SurfingNASH have changed practice. This week's Guest Surfer, Dr. Ian Rowe, devotes roughly half his time to treating patients in his Hepatology practice in Leeds, UK, and the other half on research and teaching issues. He joined the Surfers to discuss how patients were referred to his clinic and how...
22 Okt 202056min
Six Months In: How COVID-19 Has Changed Our World!
Send us a text On the six-month anniversary of SurfingNASH's first episode, the Surfers stop to consider how much has changed for NASH stakeholders since April Thursday marks the six-month anniversary of SurfingNASH's first episode. The last six months have seen both setbacks and large steps forward in drug development, major advances in disease knowledge and increased breadth and depth of patient advocacy. The Surfers reflect on all these changes while remembering key steps in the podcast's...
15 Okt 202047min
COVID-19 and the Liver, “it's complicated - Ep 29
Send us a text Matt Kelly, Chief Innovation Officer at Perspectum, Ltd., joins the Surfers to discuss early findings from the COVERSCAN study which looks at the relationship between COVID-19 infection and major end-organ systems. Matt Kelly, Chief Innovation Officer at Perspectum, Ltd. joins the Surfers to discuss two studies that look at the relationship between COVID-19 and the liver. In the COVERSCAN study, Perspectum plans to conduct multi-organ scans of 500 patients who have recovered f...
8 Okt 202054min
Wild Times in NASH-Ville Part 3: Better Days ARE Ahead! Ep 28
Send us a text Stephen Harrison leads the Surfers through a review of FGF-21s and other exciting drug development news. Stephen Harrison starts this week's discussion reviewing the recent announcement of a promising Phase 1b/2a study for 89bio-100 (link to slide deck below), an FGF-21 agent that demonstrated significant reductions on liver fat and had positive effects on other metabolic measures. The discussion broadened to address an array of issues: other agents in development; changing (h...
1 Okt 202048min
Crystal Ball Tells Us The Most Important Stories Of Autumn - Ep 27
Send us a text The Surfers discuss four issues that are likely to affect how our thinking about NASH diagnosis, education, and treatment might evolve over the next three months. Naim Alkhouri joins the Surfers to discuss some key NASH-related questions. The four key sections address upcoming clinical trials, steps forward in patient advocacy, the UK NCD report and need for patient education, and the pervasive impact of COVID-19 on how we think and talk about liver disease. Always lively, alw...
24 Sep 202055min
