The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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The Secret Peptides and Underground Compounds Doctors Won’t Talk About : 1413

The Secret Peptides and Underground Compounds Doctors Won’t Talk About : 1413

What if the line between “medicine” and “forbidden” has nothing to do with safety and everything to do with permission? This episode gives you a clear framework for understanding peptides, research ch...

10 Feb 59min

Why Your Muscles Break Down After 40 (Do This To Reverse It) : 1412

Why Your Muscles Break Down After 40 (Do This To Reverse It) : 1412

Your muscles play a far bigger role in aging than most people realize. As you get older, the energy factories inside your muscle cells begin to break down and stop getting replaced, leading to fatigue...

8 Feb 10min

Biohackers in the Epstein Files, Generic GLP-1s, Continuous Ketone Monitors, and more... : 1411

Biohackers in the Epstein Files, Generic GLP-1s, Continuous Ketone Monitors, and more... : 1411

This episode covers: • Longevity Influence In The Epstein Files A new DOJ document release tied to the Epstein investigation pulled physician and longevity influencer Peter Attia into the spotlight, a...

6 Feb 7min

Why 18-Year-Olds Wake Up Fresh (And You Don't)  : 1410

Why 18-Year-Olds Wake Up Fresh (And You Don't) : 1410

18-year-olds wake up fresh because their repair system still works. This episode shows you how stem cell decline quietly drives fatigue, inflammation, and faster aging, and how fasting can reactivate ...

5 Feb 58min

STOP Intermittent Fasting If You Want to Stay Young : 1409

STOP Intermittent Fasting If You Want to Stay Young : 1409

STOP intermittent fasting if you think it automatically keeps you young. In this episode, you’ll learn why short-term fasting results can mislead long-term aging outcomes, and how duration, frequency,...

3 Feb 1h 17min

Aging Starts In Your Legs (Here’s The Fix) : 1408

Aging Starts In Your Legs (Here’s The Fix) : 1408

Most people think aging starts with wrinkles, gray hair, or memory loss. It doesn’t.Aging starts when your legs begin to weaken, long before you notice it.In this video, you’ll learn why your leg musc...

1 Feb 8min

The Nobel Prize Molecule That Nearly Doubles Lifespan : 1407

The Nobel Prize Molecule That Nearly Doubles Lifespan : 1407

In the late 1990s, a strange carbon molecule quietly delivered the single longest lifespan extension ever recorded in mammals. The rats lived about 90% longer, and almost no one was paying attention. ...

30 Jan 1h 4min

Meet the Governor Who Wants Humans to Become Cyborgs  : 1406

Meet the Governor Who Wants Humans to Become Cyborgs : 1406

Aging is not something Zoltan Istvan plans to accept quietly. He wants to treat death like a technical bug, rewrite the rules of biology, and turn California into the global test bed for radical human...

29 Jan 1h 7min

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