#120 - How Sleep Deprivation Hijacks Your Genetic Code
Putting sleep deprivation under the microscope yet again, Matt explores our "genetic workforce" of 20,000 genes operating on a precise 24-hour cycle. He details 2013 research showing that just one wee...
5 Jan 20min
The Midnight Bookshop: A Sleep Story Read by Matt Walker
Join Matt to leave the day’s rush behind. After a brief breathing exercise to settle the mind and body, you will find yourself on a quiet street in a British village. Matt leads you across a small sto...
29 Dec 202524min
#119 - Your Brain On GLP-1s
Exploring GLP-1 agonists in a new light, Matt examines a review that positions these metabolic hormones as potential brain defenders. He details their surprising presence in memory centers and their c...
22 Dec 202520min
#118 - A Sleep Medication to Lower the Risk of Alzheimer's
Matt examines the critical link between sleep quality and Alzheimer’s pathology. He details the brain's "night shift" - the glymphatic system - which actively flushes out toxins like amyloid beta duri...
15 Dec 202519min
Ask Me Anything Part 23: The Gut, Grief, Creativity, and Microsleeps
In this latest AMA episode, Matt and Dr. Eti Ben Simon explore the complex web connecting sleep to our health and daily lives. They investigate the gut-brain axis, discussing how sleep deprivation alt...
8 Dec 202557min
#117 - Can Creatine & Exercise Overcome Sleep Deprivation?
Matt confronts the systemic failure of sleep deprivation, examining its impact on our biological machinery. When sleep is short, the body's "fuel gauge" dips, impairing mitochondrial function and gluc...
1 Dec 202518min
#116 - 40 Hz Brain Stimulation
Matt ventures into the realm of 40 Hz "gamma" rhythms - the conductor of the biological orchestra during high-order cognition - to explore how non-invasive light and sound stimulation can entrain brai...
24 Nov 202525min
#115 - Sleep Deprivation for Depression
The counterintuitive use of sleep deprivation as a rapid treatment for major depression finds itself squarely in Matt’s spotlight today. He begins by discussing its origins in the 1970s, where one nig...
17 Nov 202517min
