On modeling metabolic networks in the brain – with Polina Shichkova - #35
Neurons need particular sodium and potassium concentration gradients across their membranes to function. These gradients are set up by so-called ion pumps which require energy stored in ATP molecules ...
6 Dec 20251h 31min
On balanced neural networks - with Nicolas Brunel - #34
An important discovery that has come out of computational neuroscience, is that cortical neurons in vivo appear to receive so-called balanced inputs. In the balanced state the excitatory and inhibitor...
8 Nov 20251h 38min
On computational neurotechnology for the clinic - with Anthony Burkitt, Nada Yousif & Esra Neufeld - #33
How can computational neuroscience contribute to developing neurotechnology to help people with brain disorders and disabilities? This was the topic of a panel debate I hosted at the 34th Annual Compu...
11 Okt 20251h
On IIT and adversarial testing of consciousness theories - with Christof Koch - #32
In an adversarial collaboration researchers with opposing theories jointly investigate a disputed topic by designing and implementing a study in a mutually agreed unbiased way. Results from adversaria...
13 Sep 20252h 17min
On how to cure brain diseases - with Nicole Rust - #31
A promise of basic neuroscience research is that the new insights will lead to new cures for brain diseases. But has that happened so far? Today's guest, an accomplished professor of neuroscience, dec...
16 Aug 20252h 13min
On co-dependent excitatory and inhibitory plasticity - with Tim Vogels - #30
Synaptic plasticity underlies several key brain functions including learning, information filtering and homeostatic regulation of overall neural activity. While several mathematical rules have been de...
19 Juli 20251h 30min
On the philosophy of simplification in computational neuroscience - with Mazviita Chirimuuta and Terrence Sejnowski - #29
Computational neuroscientists rely on simplification when they make their models. But what is the right level of simplification? When should we, for example, use a biophysically detailed model and whe...
21 Juni 20251h 24min
On whole-cell modeling of bacteria - with Markus Covert - #28
A future computational neuroscience project could be to model not only the signal processing properties of neurons, but also all processes that keep a neuron alive for, say, a 100-year life span. In 2...
24 Maj 20252h 4min
