#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Andrej Karpathy is a legendary AI researcher, engineer, and educator. He's the former director of AI at Tesla, a founding member of OpenAI, and an educator at Stanford. Please support this podcast by checking out our sponsors: - Eight Sleep: https://www.eightsleep.com/lex to get special savings - BetterHelp: https://betterhelp.com/lex to get 10% off - Fundrise: https://fundrise.com/lex - Athletic Greens: https://athleticgreens.com/lex to get 1 month of fish oil EPISODE LINKS: Andrej's Twitter: http://twitter.com/karpathy Andrej's YouTube: http://youtube.com/c/AndrejKarpathy Andrej's Website: http://karpathy.ai Andrej's Google Scholar: http://scholar.google.com/citations?user=l8WuQJgAAAAJ Books mentioned: The Vital Question: https://amzn.to/3q0vN6q Life Ascending: https://amzn.to/3wKIsOE The Selfish Gene: https://amzn.to/3TCo63s Contact: https://amzn.to/3W3y5Au The Cell: https://amzn.to/3W5f6pa PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (05:41) - Neural networks (10:45) - Biology (16:15) - Aliens (26:27) - Universe (38:18) - Transformers (46:34) - Language models (56:45) - Bots (1:03:05) - Google's LaMDA (1:10:28) - Software 2.0 (1:21:28) - Human annotation (1:23:25) - Camera vision (1:28:30) - Tesla's Data Engine (1:32:39) - Tesla Vision (1:39:09) - Elon Musk (1:44:17) - Autonomous driving (1:49:11) - Leaving Tesla (1:54:39) - Tesla's Optimus (2:03:45) - ImageNet (2:06:23) - Data (2:16:15) - Day in the life (2:29:31) - Best IDE (2:36:37) - arXiv (2:41:06) - Advice for beginners (2:50:24) - Artificial general intelligence (3:03:44) - Movies (3:09:37) - Future of human civilization (3:13:56) - Book recommendations (3:20:05) - Advice for young people (3:21:56) - Future of machine learning (3:28:44) - Meaning of life

29 Loka 20223h 33min

Ye is a legendary artist, producer, and designer. Please support this podcast by checking out our sponsors: - Shopify: https://shopify.com/lex to get free trial - InsideTracker: https://insidetracker.com/lex to get 20% off - ExpressVPN: https://expressvpn.com/lexpod to get 3 months free - Athletic Greens: https://athleticgreens.com/lex to get 1 month of fish oil EPISODE LINKS: Ye's Twitter: https://twitter.com/kanyewest Ye's Instagram: https://instagram.com/kanyewest Ye's Website: https://kanyewest.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:26) - Engineering (18:21) - Kim Kardashian (20:07) - Sex and the future of humanity (30:12) - Happiness (32:49) - The Holocaust (1:21:58) - Fashion (1:37:31) - 2024 US election (1:42:10) - Humor (1:44:20) - Media and antisemitism (1:56:23) - Trusting people (1:59:37) - Accountability (2:09:36) - Legacy (2:10:28) - Advice for young people (2:23:29) - Regret

24 Loka 20222h 33min

Balaji Srinivasan is an angel investor, tech founder, philosopher, and author of The Network State: How to Start a New Country. He was formerly the CTO of Coinbase and General Partner at Andreessen Horowitz. Please support this podcast by checking out our sponsors: - Policygenius: https://www.policygenius.com/ - Blinkist: https://blinkist.com/lex to get 25% off premium - Notion: https://notion.com - Onnit: https://lexfridman.com/onnit to get up to 10% off EPISODE LINKS: Balaji's Twitter: https://twitter.com/balajis Balaji's Website: https://balajis.com Books: 1. The Network State: https://thenetworkstate.com 2. Reputation and Power: https://amzn.to/3eyQiF6 3. Exit, Voice, and Loyalty: https://amzn.to/3TpuLNP 4. Seeing Like a State: https://amzn.to/3MJfvcD Articles: 1. Bitcoin Is Civilization: https://www.commonsense.news/p/is-bitcoin-anarchy-or-civilization 2. Great Protocol Politics: https://foreignpolicy.com/2021/12/11/bitcoin-ethereum-cryptocurrency-web3-great-protocol-politics 3. Regulation, Disruption, and the Future: https://bit.ly/3CKY9Ys 4. The Measured Man: https://theatlantic.com/magazine/archive/2012/07/the-measured-man/309018 5. Secret Document That Transformed China: https://npr.org/sections/money/2012/01/20/145360447/the-secret-document-that-transformed-china 6. Hollywood's Missing Movies: https://reason.com/2000/06/01/hollywoods-missing-movies 7. New York Times Truth Campaign: https://adweek.com/agencyspy/droga5s-first-big-campaign-for-the-new-york-times-is-all-about-the-truth/126274 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:23) - Prime number maze (33:35) - Government (49:51) - The Network State (59:55) - Pseudonymous economy (1:23:41) - Exit (1:38:23) - Building a network state (2:26:09) - Wikipedia (3:03:40) - Fixing science (3:30:08) - Fixing the FDA (5:01:16) - Longevity (5:20:14) - Donald Trump's ban from social media (5:49:32) - War (5:56:41) - Censorship (6:10:40) - Social media (6:26:56) - Wokeism and communism (6:45:44) - Cryptocurrency (7:03:17) - AI, AR, and VR (7:15:15) - Advice for young people (7:48:10) - Regulating logic

20 Loka 20227h 53min

Hikaru Nakamura is a chess super grandmaster and is currently the #1 ranked blitz chess player in the world. He is also one of the top chess streamers on Twitch and YouTube. Please support this podcast by checking out our sponsors: - Mizzen+Main: https://mizzenandmain.com and use code LEX to get $35 off - InsideTracker: https://insidetracker.com/lex to get 20% off - NetSuite: http://netsuite.com/lex to get free product tour - SimpliSafe: https://simplisafe.com/lex EPISODE LINKS: Hikaru's Twitch: https://twitch.tv/gmhikaru Hikaru's YouTube: https://www.youtube.com/GMHikaru Hikaru's Twitter: https://twitter.com/GMHikaru Hikaru's Instagram: https://instagram.com/gmhikaru Hikaru's Website: https://hikarunakamura.com Macauley Peterson's video: https://youtube.com/watch?v=tGXvcQP6VPo PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:59) - A private game vs Magnus Carlsen (14:47) - Chess openings (30:59) - Mental preparation (39:40) - Chess tactics (50:03) - Solving chess (55:43) - Aggression and ego (1:00:28) - Hans Niemann cheating scandal (1:10:21) - How to cheat in chess (1:24:44) - Greatest chess player of all time (1:35:00) - Hikaru's immortal game (1:47:26) - Paul Morphy (1:49:10) - World Chess Championship (1:51:59) - Magnus Carlsen (1:55:33) - Sergey Karjakin (1:58:00) - Beauty of chess (2:04:55) - Day in the life (2:19:34) - Streaming (2:34:13) - Taking risks (2:39:42) - Depression (2:44:31) - Advice for young people (2:51:51) - Love

17 Loka 20222h 54min

Kate Darling is a researcher at MIT Media Lab interested in human robot interaction and robot ethics. Please support this podcast by checking out our sponsors: - True Classic Tees: https://trueclassictees.com/lex and use code LEX to get 25% off - Shopify: https://shopify.com/lex to get 14-day free trial - Linode: https://linode.com/lex to get $100 free credit - InsideTracker: https://insidetracker.com/lex to get 20% off - ExpressVPN: https://expressvpn.com/lexpod to get 3 months free EPISODE LINKS: Kate's Twitter: http://twitter.com/grok_ Kate's Website: http://katedarling.org Kate's Instagram: http://www.instagram.com/grok_ The New Breed (book): https://amzn.to/3ExhBuf Creativity without Law (book): https://amzn.to/3MqV5F3 LuLaRobot (paper): http://drive.google.com/file/d/1PtYpkDQaQVPbhQIc6wcCC50JKWVsDo3k/view PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:57) - What is a robot? (23:57) - Metaverse (33:19) - Bias in robots (47:02) - Modern robotics (49:34) - Automation (53:57) - Autonomous driving (1:02:22) - Privacy (1:05:48) - Google's LaMDA (1:10:35) - Robot animal analogy (1:23:38) - Data concerns (1:41:40) - Humanoid robots (2:00:42) - LuLaRobot (2:09:36) - Ethics in robotics (2:24:57) - Jeffrey Epstein (2:58:31) - Love and relationships

15 Loka 20223h 9min

John Danaher is one of the greatest coaches and minds in martial arts history. Please support this podcast by checking out our sponsors: - Audible: https://audible.com/lex to get 30-day free trial - Calm: https://calm.com/lex to get 40% off premium - Indeed: https://indeed.com/lex to get $75 credit - MasterClass: https://masterclass.com/lex to get 15% off - Eight Sleep: https://www.eightsleep.com/lex to get special savings EPISODE LINKS: John's Instagram: https://instagram.com/danaherjohn Watch full matches at FloGrappling: https://flograppling.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:51) - Road to ADCC (26:23) - Danaher Death Squad (35:07) - Mental preparation (59:52) - Gordon Ryan (1:56:50) - Giancarlo Bodoni (2:21:57) - Garry Tonon (2:35:54) - Nicholas Meregali (2:51:21) - Ruotolo brothers (3:01:00) - Takedowns (3:05:19) - GSP (3:13:48) - Renzo Gracie (3:18:24) - Boris (3:22:15) - Ali Abdelaziz (3:24:41) - Khabib Nurmagomedov (3:28:33) - Joe Rogan playing pool (3:31:47) - Advice for grapplers (3:41:43) - Day in the life (3:48:25) - Bear vs Gorilla vs Lion vs Anaconda (4:26:12) - Tom Hardy (4:37:46) - Emojis (4:40:15) - Love (4:45:38) - Fighting to the death (4:49:25) - Knives

10 Loka 20224h 55min

Levy Rozman, also known as GothamChess, is a professional chess player, streamer, and educator. Please support this podcast by checking out our sponsors: - Notion: https://notion.com - Athletic Greens: https://athleticgreens.com/lex to get 1 month of fish oil - ExpressVPN: https://expressvpn.com/lexpod to get 3 months free - InsideTracker: https://insidetracker.com/lex to get 20% off EPISODE LINKS: GothamChess's YouTube: https://youtube.com/gothamchess GothamChess's Twitch: https://twitch.tv/gothamchess GothamChess's Twitter: https://twitter.com/GothamChess GothamChess's Instagram: https://instagram.com/gothamchess GothamChess's Website: https://gotham-chess.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:14) - Elo rating (07:18) - Chess.com vs lichess.org (18:09) - Teaching chess (22:37) - Magnus Carlsen (37:52) - Greatest chess player of all time (42:35) - Hans Niemann cheating scandal (44:04) - Pin of Shame (58:12) - Bullying (1:00:04) - Indonesia incident (1:11:39) - Retiring from chess (1:18:16) - Death (1:21:58) - Streamers (1:35:34) - Hans Niemann cheating scandal continued (2:13:16) - Magnus Carlsen's statement (2:24:37) - Podcasts (2:27:04) - Parasocial interaction (2:30:53) - How to cheat in chess (2:40:39) - Reddit questions (2:47:03) - Chess boxing (2:55:49) - Chess bots (3:01:31) - AlphaZero (3:07:18) - Did Hans Niemann cheat? (3:14:34) - Chess openings (3:19:14) - Magnus Carlsen's poker game (3:21:56) - Chess advice (3:28:17) - Depression

7 Loka 20223h 38min

Annaka Harris is the author of Conscious: A Brief Guide to the Fundamental Mystery of the Mind. Please support this podcast by checking out our sponsors: - Wealthfront: https://wealthfront.com/lex to get $50 sign-up bonus - BetterHelp: https://betterhelp.com/lex to get 10% off - Blinkist: https://blinkist.com/lex to get 25% off premium - Onnit: https://lexfridman.com/onnit to get up to 10% off - Indeed: https://indeed.com/lex to get $75 credit EPISODE LINKS: Annaka's Twitter: http://twitter.com/annakaharris Annaka's Website: http://annakaharris.com Annaka's Facebook: http://facebook.com/annakaharrisprojects Annaka's Books: 1. Conscious: https://amzn.to/3SFLLPE 2. I Wonder: https://amzn.to/3UPQTTm Annaka's Articles: 1. What Is Time?: http://nautil.us/what-is-time-238478 2. A Solution to the Combination Problem: http://annakaharris.com/the-future-of-panpsychism 3. Consciousness Isn’t Self-Centered: http://nautil.us/consciousness-isnt-self_centered-237720 Books: 1. The Case Against Reality: https://amzn.to/3MhW4Wt 2. Being You: https://amzn.to/3RsxdBQ 3. Livewired: https://amzn.to/3Cn9BKS 4. Spooky Action at a Distance: https://amzn.to/3y27N7a 5. The Order of Time: https://amzn.to/3Stqn0u PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:20) - Free will (1:00:37) - Consciousness (1:31:09) - Depression (1:44:26) - Psychedelics (1:52:25) - Meditation (1:56:49) - Ideas (2:20:35) - AI sentience (2:37:56) - Suffering (2:40:53) - Meaning of life

5 Loka 20222h 46min