Communicable E45: Top infectious diseases papers in 2025

In this episode of Communicable, Josh Davis (Newcastle, Australia) and Emily McDonald (Montreal, Canada), plus invited guest, Steven Tong (Melbourne, Australia)—all practicing physicians and clinical trialists—assemble to discuss some of their ‘top infectious diseases papers published in 2025’. Bassam Ghanem (Jeddah, Saudi Arabia), whom one might know better as Antibiotic Steward on social media, was also invited to share his favourite publications of 2025.

Six papers that were most consistently picked by the panel are presented, explaining why they were picked and how they have shifted paradigms or changed their practice. This episode complements the previous episode, which presented ‘top clinical microbiology papers in 2025’, and was peer reviewed by Akshatha Ravindra of Kasturba Medical College, Manipal, India.

Resources

CLARITY initiative website

Papers presented (in order of presentation)

Turner NA, et al. Dalbavancin for Treatment of Staphylococcus aureus Bacteremia. JAMA
Meya DB, et al. Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis. NEJM
Vodstrcil LA, et al. Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis. NEJM
Kreimer A, et al. Noninferiority of One HPV Vaccine Dose to Two Doses. NEJM
Guglielmetti L, et al. Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis. NEJM
Ross JDC et al, Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1). Lancet

‘One liners’ (in order of presentation)

Burdet C et al. Cloxacillin versus cefazolin for meticillin-susceptible Staphylococcus aureus bacteraemia (CloCeBa). Lancet
Lemiale V et al, Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia (PIC). Lancet Respir Med
Luetkemeyer AF et al, Doxycycline to prevent bacterial sexually transmitted infections in the USA. Lancet Inf Dis
Eyting M, et al. A natural experiment on the effect of herpes zoster vaccination on dementia. Nature
Xie M, et al. The effect of shingles vaccination at different stages of the dementia disease course. Cell
Pomirchy M, et al. Herpes Zoster Vaccination and Dementia Occurrence. JAMA
Durbin AP et al, Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model. NEJM
Hook EW et al, One Dose versus Three Doses of Benzathine Penicillin G in Early Syphilis. NEJM
Opdam MAA et al, Continuation versus temporary interruption of immunomodulatory agents during infections in patients with inflammatory rheumatic diseases. Clin Infect Dis
Arundel C et al, Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2). Lancet

Honourable mentions

Chaccour C, et al. Ivermectin to Control Malaria. NEJM
Lucinde RK, et al. A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia. NEJM
Morel J, et al. Effect of a 1-month methotrexate delay on pneumococcal vaccine immunogenicity and disease control in patients with early rheumatoid arthritis (VACIMRA). Lancet Rheumatol
Haukoos J, et al. Hepatitis C Screening in Emergency Departments. JAMA
Major Extremity Trauma Research Consortium (METRC). Oral vs Intravenous Antibiotics for Fracture-Related Infections: The POvIV Randomized Clinical Trial, JAMA Surg
Anderson CS, et al. Influenza vaccination to improve outcomes for patients with acute heart failure (PANDA II). Lancet
St Peter SD, et al. Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children. Lancet
Pan CQ, et al. Tenofovir and Hepatitis B Virus Transmission During Pregnancy. JAMA
Gohil SK, et al. Improving Empiric Antibiotic Selection for Patients Hospitalized With Abdominal Infection. JAMA Surg

Related podcast episodes

Communicable E44: Top clinical microbiology papers in 2025 https://share.transistor.fm/s/6e5c26ae
Communicable E29: Bacterial vaginosis & male partners, https://share.transistor.fm/s/3de4f5c3
Communicable E28: Late-breaker trials at ESCMID Global: Should they change your practice? - part 2, https://share.transistor.fm/s/4f044e8c
Communicable E20: Tuberculosis today https://share.transistor.fm/s/9858900e

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