How body fat affects your metabolic health and risk of metabolic disease | Dr Robert Eckel

I’m joined by Dr Robert Eckel to unpack why obesity is far more complex than a BMI number and why insulin resistance plays such a central role in cardiometabolic disease. We discuss preclinical versus clinical obesity, fat distribution, metabolic risk, and what actually improves health outcomes beyond weight loss alone. What We Cover Why BMI is only a starting point Preclinical versus clinical obesity explained Why visceral fat matters more than total fat How insulin resistance develops with excess body fat Who may benefit most from weight loss interventions GLP-1 therapies, benefits and open questions A practical, evidence-based conversation that reframes how we think about obesity, risk and long term health. Introduction (00:00) Clinical vs Preclinical Obesity: How Should Obesity Be Defined? (05:21) Why Is Obesity Difficult to Diagnose and Treat in Practice? (08:06) How Genetics and Environment Influence Body Fat Gain (20:27) What Is Insulin Resistance and Metabolic Syndrome? (32:23) How Insulin Sensitivity Relates to Clinical Obesity (55:26) Why Insulin Resistance Begins in Adipose Tissue (59:49) Physiological vs Pathological Insulin Resistance Explained (01:04:47) How Physical Activity Improves Insulin Sensitivity (01:10:46) Family History, Genetics, and Cardiometabolic Risk (01:12:30) Individualised Obesity Treatment Guidelines in Clinical Care (01:15:40) How GLP-1 Receptor Agonists Are Used in Obesity Management (01:16:12) What Is the Obesity Paradox in Cardiometabolic Disease? (01:22:01) Future Projections for Obesity and Cardiometabolic Health (01:30:07) Public Health Challenges in Preventing Excess Adiposity (01:40:23) Practical Clinical Takeaways and Final Thoughts (01:44:15) Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family. This episode is brought to you by: 38TERA Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eight Sleep Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Host of The Proof with Simon Hill Author of The Proof is in the Plants Subscribe & Connect: YouTube Apple Podcasts Spotify Instagram: @simonhill Twitter: @theproof Facebook: The Proof with Simon Hill Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(426)

The Fertility Test Most Men Are Never Offered | Dr Michael Eisenberg and Dr Natalie Crawford

About one in seven couples are unable to conceive after a year of trying, and roughly half of those cases involve a male contribution. Yet in a quarter to a third of them, the man is never properly ev...

10 Elo 2h 3min

Superagers, statins, the latest cholesterol pill and the truth about heart disease risk | Dr Terry Simpson

Dr Terry Simpson is back, and we go deep on the science of protecting your heart and brain for the long run. He is a surgeon and one of the clearest voices online for separating solid evidence from co...

4 Elo 1h 53min

The Science of Metabolic Flexibility, Zone 2, and Reversing Diabetes | A Masterclass

Metabolic dysfunction rarely announces itself. We tend to think of metabolic health as a line you cross the day you are diagnosed with type 2 diabetes, but the decay usually begins years earlier, at t...

27 Heinä 2h 20min

New Science of Weight Loss | A Masterclass

GLP-1 medications are transforming obesity treatment, but they're only one piece of the puzzle. In this masterclass, I bring together insights from Dr Terry Simpson, Dr Federica Amati, Dr Mauricio Gon...

20 Heinä 1h 54min

Fertility, Sperm Health, and Nutrition Before and During Pregnancy | Dr Federica Amati

We tend to treat pregnancy as the starting line for a child's health. In this episode, Dr Federica Amati, Head Nutritionist at ZOE, makes the evidence-based case that the window opens earlier, in the ...

13 Heinä 1h 23min

Can You Reverse Heart Disease? What My Plaque Scans Showed | Dr Campbell Rogers

In late 2024 a CT scan revealed a small amount of soft plaque in my arteries. Sixteen months later I scanned again, and my plaque volume had dropped by around forty percent. In this episode I ask the ...

6 Heinä 1h 15min

Reversing Artery Plaque: 8 Supplements Ranked by the Evidence | Simon Hill, MSc

Can a supplement actually reverse the plaque in your arteries, or only slow it down? It is the question I am asked most, and after a 2024 scan revealed early plaque in my own left anterior descending ...

29 Kesä 1h 1min

How to Lose Weight and Fix Your Metabolism in 2026 | Dr Mauricio Gonzalez

For decades we have treated the number on the scale as the goal of metabolic health. Dr Mauricio Gonzalez, a triple board-certified physician and endocrinology fellow practising in New York, makes the...

22 Kesä 1h 29min