#418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum

#418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum

Today, I'm joined by the insightful Courtney Van Bussum, a biomedical engineer and entrepreneur who has become a rising force in longevity science. Courtney shares how growing up in a family of healthcare innovators shaped her journey, and how she pivoted from startup life to tackling age-related challenges—especially when COVID brought her back to her roots and reignited her passion for cellular health. If you want to try Endotelio 1-MNA and save 10% click here and code NAT10 will be entered for you at checkout. Episode Timestamps: Welcome and introduction to Longevity Podcast ... 00:00:00 Challenging beliefs about aging and cellular health ... 00:12:00 Deep dive into NAD+ biochemistry and cellular function ... 00:13:08 NAD+/NADH balance: Why both matter ... 00:15:24 Why NAD+ declines: Not just aging, but increased degradation ...00:18:26 The role of CD38 and NMNT enzymes in NAD metabolism ... 00:20:14 Controversy and confusion: NAD+ precursors (NR, NMN) and IVs ... 00:22:28 Methylation's hidden importance in NAD supplementation ... 00:30:55 Supplementing 1-MNA: Understanding dosages and applications ... 00:50:54 Assessing NAD+ status: Biomarkers and limitations of testing ... 00:53:01 Lifestyle ROI: Sleep, exercise, and circadian rhythm for NAD preservation ... 00:57:14 Ketones: Beyond performance, supporting cellular energy and longevity ... 01:06:03 Future of NAD science: Anticipating new insights and risks ... 01:11:45 Confidence and humility: Advice for navigating the longevity field ... 01:18:52 Our Amazing Sponsors: Qualia Creatine+ by Qualia Life – A clinically formulated blend of two highly bioavailable forms of creatine plus magnesium and electrolytes to support lean muscle, cellular energy, and brain health—especially for women over 40 who naturally produce less with age. Go to qualialife.com/nathalie and use code NATHALIE to save up to 50%, plus an additional 15% off. Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off. Gut Essentials Bundle by Just Thrive Health – This powerhouse duo pairs the only probiotic clinically proven to arrive 100% alive in your gut with science-backed Digestive Bitters to reduce bloat, curb cravings, and support better energy fast. Take the Just Thrive Feel Better Challenge and save 20% at justthrivehealth.com/NAT20 with code NAT20. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

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#432: Midlife Wake-Up Call: Why Doing Less Is Important During The Peri- and Menopausal Transition With Cynthia Thurlow

#432: Midlife Wake-Up Call: Why Doing Less Is Important During The Peri- and Menopausal Transition With Cynthia Thurlow

Today, I’m joined by the insightful Cynthia Thurlow, a leading voice in women’s health and the acclaimed author of The Menopause Gut. In this episode, Cynthia Thurlow gets real about the chaos of peri...

24 Huhti 1h 13min

#431: Humic and Fulvic Minerals: Nature’s Solution for Energy, Detox, and Lasting Health With Caroline Alan

#431: Humic and Fulvic Minerals: Nature’s Solution for Energy, Detox, and Lasting Health With Caroline Alan

Today, I’m joined by the insightful Caroline Alan, author of The Mineral Reset and co-founder of Beam Minerals. Caroline Alan shares her powerful story—a decade-long journey from chronic fatigue, brai...

21 Huhti 1h 29min

#430: Most Impactful Pod Moments This Year: Mitochondrial Transplants, Weight Loss, Resilience Through Trauma, Heart Tests & Tryptophan After COVID

#430: Most Impactful Pod Moments This Year: Mitochondrial Transplants, Weight Loss, Resilience Through Trauma, Heart Tests & Tryptophan After COVID

Today, I’m pulling together some of the most impactful conversations from the last three months on the Podcast. From breaking down the pitfalls of trendy weight loss drugs to uncovering silent heart h...

17 Huhti 56min

#429: Redefining CANCER: Metabolic Flexibility, Radical Remission, and The One Terrain Shift That Changes Everything With Dr. Nasha Winters

#429: Redefining CANCER: Metabolic Flexibility, Radical Remission, and The One Terrain Shift That Changes Everything With Dr. Nasha Winters

Today, I’m joined by the remarkable Dr. Nasha Winters, whose personal journey of facing stage four cancer at just 19 years old turned into a decades-long mission to rethink the narrative around cancer...

14 Huhti 1h 38min

#428: Poop, Peptides & The Power of Microbiome | The Secret Longevity Organ With Dr. Grace Liu

#428: Poop, Peptides & The Power of Microbiome | The Secret Longevity Organ With Dr. Grace Liu

Today, I'm joined by Dr. Grace Liu, often known as the “Gut Goddess,” a trailblazer in the world of microbiome science and founder of The Gut Institute. In this conversation, we take a bold dive into ...

10 Huhti 1h 24min

#427: The Hidden Link Between Vision, Longevity & Anxiety | Spatial Empathy, Screens & the 20-20-20 Rule With Dr. Meenal Agarwal

#427: The Hidden Link Between Vision, Longevity & Anxiety | Spatial Empathy, Screens & the 20-20-20 Rule With Dr. Meenal Agarwal

Today, I'm joined by the insightful Dr. Meenal Agarwal, an eye doctor and passionate advocate for reimagining how we think about vision and brain health. In our conversation, Dr. Agarwal reveals the s...

7 Huhti 1h 27min

#426: The Invisible Price of Poor Sleep and How To Fix It, Tech Hacks That Save Marriages, and the Longevity Equation — With Melissa Urban

#426: The Invisible Price of Poor Sleep and How To Fix It, Tech Hacks That Save Marriages, and the Longevity Equation — With Melissa Urban

Today, I'm joined by the amazing Melissa Urban, the force behind Whole30 and a global champion of accessible nutrition. In our conversation, Melissa opens up about a surprising discovery in her wellne...

3 Huhti 57min

#425: Broccoli Power: The Secret Longevity Molecule (Fighting Toxins, Microplastics & Aging) | Sulforaphane Exposed With David Roberts & Dr. John Gildea

#425: Broccoli Power: The Secret Longevity Molecule (Fighting Toxins, Microplastics & Aging) | Sulforaphane Exposed With David Roberts & Dr. John Gildea

Today, I'm joined by David Roberts and Dr. John Gildea, two passionate researchers whose work sits at the cutting edge of environmental health and longevity science. In this episode, we dive deep into...

31 Maalis 1h 24min

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