Special Episode: Lawrence Ingrassia & A Fatal Inheritance

Special Episode: Lawrence Ingrassia & A Fatal Inheritance

For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellular dynamics underlying cancer, and what they found finally allowed grief-stricken families to put a name and explanation to their experience. It wasn’t simply bad luck. It was genetics: a heritable mutation in a key tumor suppressor gene that greatly increases the risk of developing cancer in your lifetime, a condition known as Li-Fraumeni Syndrome. Journalist Lawrence Ingrassia belongs to one of those families; he has lost his mother, three siblings, and a nephew to cancer. In this TPWKY book club episode, Ingrassia joins me to discuss his book A Fatal Inheritance: How a Family Misfortune Revealed a Deadly Medical Mystery, where he weaves together his family’s story with that of the scientists who sought to uncover the cellular drivers of cancer. Tune in for a heartbreaking and inspiring journey.

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From the Vault - Endometriosis: Menstrual Backwash (Ep 88)

From the Vault - Endometriosis: Menstrual Backwash (Ep 88)

This episode originally aired on January 11th, 2022. Chances are you know someone with endometriosis, or perhaps you’re affected yourself. But despite its incredibly high prevalence, endo remains almo...

30 Joulu 20252h 11min

From the Vault - Hepatitis B: Hepatiti, Take 2 (Ep 89)

From the Vault - Hepatitis B: Hepatiti, Take 2 (Ep 89)

This episode originally aired on January 25th, 2022. In light of the recent changes by RFK jr’s Advisory Committee on Immunization Practices (ACIP) to eliminate the universal birth dose of the hepatit...

23 Joulu 20251h 30min

Ep 196 Health Myths: Fact or fiction?

Ep 196 Health Myths: Fact or fiction?

Did your grandma ever warn you against going out in the cold with wet hair because “you’ll catch your death”? Or have you ever tossed a few more carrots into your shopping basket in the hope that they...

16 Joulu 20251h 6min

Special Episode: Dr. Homer Venters & Outbreak Behind Bars

Special Episode: Dr. Homer Venters & Outbreak Behind Bars

[Content warning: self-harm, suicide, violence] In this day and age, we are equipped with an abundance of tools and knowledge to fight the spread of disease. Yet what good does that toolkit do if we l...

9 Joulu 202555min

Ep 195 Salt Part 2: The Substance

Ep 195 Salt Part 2: The Substance

We ended last week’s episode on a bit of a cliffhanger: is salt actually bad for us and if so, why does there still seem to be a debate? This week’s episode holds all the answers. We’re sifting throug...

2 Joulu 202553min

Ep 194 Salt Part 1: The Seasoning

Ep 194 Salt Part 1: The Seasoning

Have you ever thrown a pinch of spilled salt over your left shoulder? Or said to someone “well, take his opinion with a grain of salt”? Or looked up the potential salary of a job listing? Salt is so d...

25 Marras 202555min

Special Episode: Gabriel Weston & Alive

Special Episode: Gabriel Weston & Alive

In an anatomy and physiology class, you may learn how the different heart valves work to circulate your blood, how the structure of your kidney helps to maintain electrolyte levels, and how the expans...

18 Marras 202549min

Ep 193 Necrotizing Fasciitis: A strange beast

Ep 193 Necrotizing Fasciitis: A strange beast

If you were asked to describe necrotizing fasciitis in three words, you might choose: rapid, deadly, and rare. The third of those adjectives may provide some comfort, but the first two are the clear i...

11 Marras 20251h 7min

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