Special Episode: Lawrence Ingrassia & A Fatal Inheritance

Special Episode: Lawrence Ingrassia & A Fatal Inheritance

For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellular dynamics underlying cancer, and what they found finally allowed grief-stricken families to put a name and explanation to their experience. It wasn’t simply bad luck. It was genetics: a heritable mutation in a key tumor suppressor gene that greatly increases the risk of developing cancer in your lifetime, a condition known as Li-Fraumeni Syndrome. Journalist Lawrence Ingrassia belongs to one of those families; he has lost his mother, three siblings, and a nephew to cancer. In this TPWKY book club episode, Ingrassia joins me to discuss his book A Fatal Inheritance: How a Family Misfortune Revealed a Deadly Medical Mystery, where he weaves together his family’s story with that of the scientists who sought to uncover the cellular drivers of cancer. Tune in for a heartbreaking and inspiring journey.

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Jaksot(282)

Ep 192 New World Screwworm: Oh-oh here they come

Ep 192 New World Screwworm: Oh-oh here they come

It’s the stuff nightmares are made of. A fly lands on an open wound and lays hundreds of eggs, from which hatch countless ravenous maggots. There they writhe, devouring flesh, insatiable and relentles...

4 Marras 20251h 10min

Special Episode: Dr. Lindsey Fitzharris and Adrian Teal & Dead Ends!

Special Episode: Dr. Lindsey Fitzharris and Adrian Teal & Dead Ends!

Science doesn’t always get it right the first time (or the second, or the third, or even the ninety-ninth!). And while we may chuckle at the outlandish things people believed or the goofy experiments ...

28 Loka 202554min

Ep 191 Famine: More than starvation

Ep 191 Famine: More than starvation

As we learned last week, starvation extends far beyond hunger and what a lack of food does to the human body. Similarly, famine is much more than a food shortage and starvation on a population-level s...

21 Loka 20251h 10min

Ep 190 Starvation: More than hunger

Ep 190 Starvation: More than hunger

Deprived of food, our bodies do the best they can to keep us alive and functioning as long as possible. As the days pass, the rhythms of our lives change: our metabolism, our heartbeats, our hormones,...

14 Loka 20251h 4min

Special Episode: Antonia Hylton & Madness

Special Episode: Antonia Hylton & Madness

The United States is in the midst of a monumental mental health crisis, with one in four people predicted to experience mental illness at some point in their lives. Adequate mental health care remains...

7 Loka 202556min

Ep 189 Newborn screening: The future is here

Ep 189 Newborn screening: The future is here

Every year, millions of babies around the world are screened for dozens of treatable conditions within the first day or two of life. What it takes is a few drops of blood on some filter paper, and wha...

30 Syys 20251h 18min

Ep 188 Candida yeast: Here, there, and everywhere

Ep 188 Candida yeast: Here, there, and everywhere

None of us are ever truly alone. Our bodies are home to untold numbers of microbes, chilling on our skin, in our guts, throughout our respiratory tract, inside our bellybuttons, under our fingernails,...

23 Syys 20251h 17min

Special Episode: Mary Roach & Replaceable You

Special Episode: Mary Roach & Replaceable You

When your car breaks down or your fridge goes on the fritz, you can order a replacement part and get things back up and running in no time. The same cannot always be said for another intricate machine...

16 Syys 202548min

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