Managing ME/CFS and Post-COVID Symptoms with Oxaloacetate

What if aging isn't just something we accept… but something we can actually influence?

In this episode, I sit down with Alan Cash, CEO of Terra Biological and a leading researcher in oxaloacetate, to break down the science behind aging and what it really takes to support longevity at the cellular level.

We dive into one of the most consistent strategies in longevity research—calorie restriction—and how it led to a powerful discovery around oxaloacetate and its role in metabolic health. From mitochondrial function and energy production to mental clarity and inflammation, this conversation connects the dots between cutting-edge science and real-world application.

We also explore its potential in addressing chronic fatigue, long COVID, and metabolic dysfunction, and how targeting these pathways may help shift the trajectory of aging itself.

If you're serious about longevity, performance, and understanding the physiology behind aging, this is a conversation you don't want to miss.

Key takeaways:

• Oxaloacetate Potential: Works as an anti-aging supplement by replicating benefits seen in calorie restriction, enhancing mitochondrial density, and aiding glucose uptake.

• Impact on Chronic Illness: Significant improvements recorded in patients with ME/CFS and long COVID, demonstrating increased cognitive function and reduced post-exertional malaise.

• Mechanism of Action: Oxaloacetate induces energy production by increasing ATP creation efficiency, addressing chronic fatigue's energy deficiency.

• Research Insights: Published studies articulate oxaloacetate's role in reducing systemic inflammation and enhancing brain function, providing hope for those with chronic diseases.

• Safety and Usage: Generally well-tolerated and effective in widely varied doses, subject to medical guidance, making it a versatile option in the treatment landscape.

More About Alan Cash: Alan Cash serves as founder and chief science officer (CSO) at Terra Biological LLC. Terra Biological LLC is a family business started in 2006 and headquartered in San Diego, California, USA. Researching into the molecular and genomic mechanisms of aging and the effects of calorie restriction on aging, Cash developed unique molecular methods and compounds to mimic calorie restriction and extend lifespan in laboratory animals.

Alan Cash has a Master of Science in physics from the University of Oklahoma. As an entrepreneur, Cash has gained recognition and awards from the White House, INC 500 business, Ernst & Young Entrepreneur of the Year, Deloitte and Touche Technology Fast 50, and Top 100 Hotfirm. Cash and colleagues recently conducted clinical trials on the effects of Oxaloacetate, a nutritional supplement, for the treatment of physical and mental fatigue in ME/CFS patients. Their published results indicate significant reduction in fatigue in ME/CFS as well as Long COVID patients following treatment.

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