Decoding the Blueprint – The Central Dogma, Peptides, and siRNA in the Quest for Age-less Youth

In this illuminating episode of The Science of Age-less Living, Dr. Ethan Hausman-Marquis takes you on a deep dive into the very foundation of life itself: the central dogma of molecular biology.

From DNA to RNA to protein — discover how this elegant cellular assembly line governs everything from skin elasticity and energy production to repair and regeneration. Using vivid analogies, Dr. Hausman-Marquis explains why the speed and accuracy of transcription and translation are intimately linked to how we age, and how errors in this process contribute to genomic instability, protein misfolding, and inflammaging.

You’ll explore the powerful roles of peptides — nature’s precision repair crews — including GHK-Cu, Epitalon, and senotherapeutic peptides like OS-01, which fine-tune protein output, support telomere maintenance, boost collagen production, and help restore youthful gene expression.

Then, journey into the revolutionary world of siRNA (small interfering RNA) — the molecular silencers that can intercept and destroy faulty genetic instructions before they cause harm. Learn how this Nobel Prize-winning technology is moving from rare disease treatments into the frontier of longevity, with companies like Junevity targeting master transcription factors to reprogram aged cells.

Whether you’re passionate about longevity, skincare, metabolic health, or simply want to understand how your body really works, this episode will leave you with a clearer picture of how science is transforming aging from an inevitable decline into a process we can actively influence.

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Age-less by Design: The Centenarian Genes That Rewrite How We Grow Old

What separates someone managing a pharmacy's worth of medications at seventy-five from someone who's just getting started on the road to a hundred and two? In this episode, we crack open the biologica...

8 Elo 21min

The Age-less Night: How Your Pineal Gland Rewrites Your Genes While You Sleep

Most people treat sleep as simple recovery, but this episode reframes it as the nightly window in which a gland smaller than a pea helps decide how fast you age. That gland is the pineal gland, buried...

3 Elo 20min

The Age-Less Off-Ramp: What Happens When You Stop GLP-1s

The GLP-1 receptor agonists are the most effective weight loss agents ever brought to market, and their efficacy is entirely contingent on continued administration. Three randomized withdrawal studies...

26 Heinä 30min

Age-less or Overhyped? The Sixty-Year Cerebrolysin Puzzle | The Age-Less Top 20 Peptides

Episode summaryCerebrolysin is a peptide preparation with a strange résumé: developed in Austria more than sixty years ago, approved in nearly fifty countries for stroke, traumatic brain injury, and d...

17 Heinä 25min

Age-less by Design: Inside the Cell's Peptide Factory

Episode summaryRight now, inside every cell in your body, trillions of microscopic factories are assembling molecules called peptides — the short chains of amino acids your body uses to talk to itself...

14 Heinä 22min

Age-Less LL-37: The Antibiotic in Your Blood | The Age-Less Top 20 Peptides

LL-37 is the odd one out in the Age-Less peptide series. Where Humanin and MOTS-c were mitochondrial longevity signals, LL-37 is the human cathelicidin — your body's own broad-spectrum antibiotic, a s...

13 Heinä 32min

Age-Less Protection: The Real Science of Humanin | The Age-Less Top 20 Peptides

In this episode of The Science of Age-less Living, Dr. Ethan Hausman-Marquis unpacks Humanin — a molecule with one of the most remarkable origin stories in longevity science. Discovered in 2001 in the...

7 Heinä 23min

Age-Less Energy: The Real Science of SS-31 | Age-Less Top 20 Peptides

SS-31 — also known as elamipretide — occupies a category no other compound in this series can claim: it is the first mitochondria-targeted therapy ever to receive FDA approval. In this episode, Dr. Et...

30 Kesä 22min