Could GLP-1s Help With Endometriosis And PMOS Symptoms? Let's Look At The Research With Dr. Hannah Kotsiris, PT, DPT

GLP-1s have become a major trigger word recently (especially online). It seems these days every other commercial or ad is for a GLP-1 medication. We get asked all the time, “What do you think about GLP-1s as physical therapists?” So, to answer that question, we’re bringing on one of our own to talk about it! The lovely Dr. Hannah Kotsiris, our colleague at The Pelvic Institute and an amazing pelvic floor therapist, is joining us to deep dive into GLP-1s and what they could mean for certain pelvic health conditions we commonly see. We’re breaking down the science, looking beyond weight loss, and exploring their emerging potential for PMOS (formerly PCOS), endometriosis, inflammation, and more. Plus, we’re tackling the myths, side effects, and what you actually need to know before jumping on the GLP-1 train.

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Disclaimer: This podcast is for educational and entertainment purposes only and is not a substitute for medical advice, diagnosis, or treatment. While we strive to provide accurate, up-to-date information, everyone’s body is unique. Always consult a qualified healthcare provider before making any medical decisions or starting a new treatment. Listening to this podcast does not establish a patient-provider relationship. We’re here to inform, entertain, and share our experiences—but not to replace your doctor!

Sources

1. https://www.authorea.com/doi/pdf/10.22541/au.177194722.27223197/v1

2. On google scholar however does not appear to be journal article: https://www.shemed.co.uk/blog/weight-loss/endometriosis-and-glp-1-agonists

3. https://pmc.ncbi.nlm.nih.gov/articles/PMC10230051/

4. https://pmc.ncbi.nlm.nih.gov/articles/PMC8799666/ for joint OA in animals

5. Depression/anxiety https://www.sciencedirect.com/science/article/pii/S0306453015300184

6. Therapeutic effects https://pmc.ncbi.nlm.nih.gov/articles/PMC8419463/

7. https://pubmed.ncbi.nlm.nih.gov/39429275/

8. https://www.ncbi.nlm.nih.gov/books/NBK551568/

9. https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/aogs.15010

10. Benefits other than weight loss: https://harmonycompound.com/wp-content/uploads/2024/07/The-benefits-of-GLP-1-drugs.pdf

11. https://www.sciencedirect.com/science/article/pii/S1043661824002573

12. https://pmc.ncbi.nlm.nih.gov/articles/PMC3280675/

13. GLP1 general: https://static1.squarespace.com/static/69b069964a0774179afbcc48/t/69de940463f66d2c0b2b3e3c/1776194565789/DruckerNRDD2025.pdf

14. https://www.sciencedirect.com/science/article/pii/S1043661825004700

15. https://www.lilly.com/news/stories/what-to-know-about-retatrutide

16. Endo https://pmc.ncbi.nlm.nih.gov/articles/PMC7980953/pdf/nihms-1572578.pdf

17. https://www.mdpi.com/1422-0067/23/17/9583

18. https://journals.sagepub.com/doi/full/10.1177/20420188231222367

19. https://acsm.org/education-resources/trending-topics-resources/physical-activity-guidelines/

20. https://journals.sagepub.com/doi/pdf/10.1089/thy.2024.0387 thyroid cancer = no longer risk of GLP1

21. https://dom-pubs.onlinelibrary.wiley.com/doi/pdf/10.1111/dom.70291 thyroid cancer = no longer risk of GLP1

22. https://ruj.uj.edu.pl/server/api/core/bitstreams/295cf57d-9ea4-4b4c-85e5-1c1841d1fa3d/content blindness = not risk of GLP1

23. LINK blindness = not risk of GLP1

24. https://www.mdpi.com/2077-0383/14/3/944 pancreatitis = not risk of GLP1

25. https://www.sciencedirect.com/science/article/pii/S2667036425000287 pancreatitis = IS risk of GLP1

26. https://www.mdpi.com/2077-0383/14/24/8882 gallbladder disease = is not risk of GLP1

27. https://journals.sagepub.com/doi/full/10.1177/20420188251406456 gallbladder disease = IS risk of GLP1