Peptide Science vs. Peptide Hype: Dosing, Naming & the Research Nobody Reads | 25-Year Peptide Pioneer

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Jean-Francois Tremblay has been working with peptides since the 1990s — back when the only source was China, the only real literature was a forum, and melanotan cost a thousand dollars a day to synthesize. He's a pharmacist with a background in exercise physiology, he came up alongside Charles Poliquin, and his lab was the first to synthesize MOTS-c.

Which means he watched the entire field get built. And he's watching the current boom repeat mistakes that were already settled twenty years ago.

In this episode he takes apart the errors nobody in the space seems to notice: why "TB-500" doesn't reliably tell you which molecule is in the vial, why the GHK-Cu results people are excited about are mostly the copper, why the doses that sound dangerous are the ones the papers actually used, and why the human research everyone says doesn't exist has existed for decades — just not in English.

He also gives you his own protocol, which is a single weekly injection, and the reasoning that makes daily pinning unnecessary for most people. Then he does the thing almost nobody in this space does: when Drew asks him to rank SS-31 against MOTS-c, he says he doesn't know enough to answer.

If you've been running peptides for a few years and you're starting to wonder how much of what you've been told is actually true, this is the hour.

This conversation is for informational and educational purposes only and is not medical advice. Compounds discussed are research chemicals. Nothing here is a recommendation to use them. Talk to a qualified physician before changing anything.