Episode 469: Maintaining and Even Improving Cognitive Function If You're Living with MS with Dr. Anna Kratz

Cognitive changes in MS—fluctuations in processing speed, memory, and executive function—can significantly impact daily life, yet they're often misunderstood or overlooked in routine clinical exams. This week, we are joined by Dr. Anna Kratz, clinical psychologist and Professor in the Department of Physical Medicine and Rehabilitation at the University of Michigan, to discuss actionable, evidence-based ways to navigate cognitive challenges.

Dr. Kratz breaks down the latest findings from the CogDetect-MS study, exploring how daily symptom fluctuations, complex medication regimens, and common substances like caffeine and cannabis influence brain fog. She also shares practical compensatory workarounds and introduces a no-cost digital self-management resource, My MSToolKit.

We'll also explain the new framework for describing MS that's been proposed by the International Advisory Committee on Clinical Trials in Multiple Sclerosis.

We're sharing study results that reveal why detecting even a single silent lesion on an MRI should trigger an immediate conversation about stepping up to high-efficacy therapy.

And we'll tell you about 2 advanced MRI markers that can predict future cognitive decline — even in the absence of any relapses or new lesions on MRI.

We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: Maintaining and improving cognitive function :22

The International Advisory Committee on Clinical Trials in Multiple Sclerosis calls for updating the way MS is described 1:12

A study provides evidence for switching your DMT when there's even a single silent lesion on your MRI 6:53

Scientists identify two MRI markers that can predict future cognitive decline in early relapsing-remitting MS 10:53

Dr. Anna Kratz discusses maintaining and improving cognitive function 15:33

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Next week 42:33

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LINKS

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PAPER: Towards a Biologically Informed Description of Multiple Sclerosis Disease Course -- A Roadmap for Transition
https://rdcu.be/fxBw1

STUDY: Treatment Escalation After Clinically Silent MRI Lesions in Relapsing-Remitting Multiple Sclerosis
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awag252/8741305

STUDY: Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing-Remitting Multiple Sclerosis
https://onlinelibrary.wiley.com/doi/10.1002/acn3.70448

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RealTalk MS Episode 469
Guest: Dr. Anna Kratz

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