Therapeutic Estrogen for Prostate Cancer: Hot Flashes & Better Sleep | Dr. Richard Wasserbug

What if one of the hardest parts of androgen deprivation therapy is not simply low testosterone—but the loss of estradiol that comes with it?

Dr. Richard Wassersug brings a rare dual perspective to that question.

He is a PhD evolutionary biologist, former professor of anatomy and neurobiology, prostate cancer quality-of-life researcher, co-developer of an androgen deprivation education program, and a patient who has used transdermal estradiol for more than two decades. His experience helped drive a deeper investigation into whether estrogen delivered through the skin could suppress testosterone while avoiding some of the burdens associated with standard LHRH-based ADT.

In this episode, you’ll learn:

🟠 Why men need estradiol for **brain, bone, sexual, and overall health.**

🟠 What the **PATCH research** suggests about transdermal estradiol, cancer control, and quality of life.

🟠 Why **hot flashes, poor sleep, fatigue, and cognitive symptoms** may reflect more than testosterone loss.

🟠 What men should know about **gynecomastia, monitoring, exercise, and shared decision-making** before considering this emerging strategy.

decision-making before considering this emerging strategy.

Chapters

00:00 ADT Side Effects Question

00:54 Podcast Disclaimers

01:33 Meet Dr Wassersug

03:59 Diagnosis And Early Treatment

04:58 Finding Estradiol Research

07:29 Lupron Side Effects And Sleep

08:48 Why Men Need Estradiol

11:00 Switching To Estradiol

15:13 NEJM Patch Trial Breakdown

20:53 Gynecomastia And Management

24:07 Real World Patient Stories

25:20 Sponsor Message Break

27:51 Access Barriers And Limits

29:03 ADT Protocols and Sleep

31:32 Estradiol Targets and Ratios

37:23 Patch vs Gel Dosing

39:10 Combining ADT With Estradiol

42:52 Who Benefits Most

44:18 PATCH Study Scope and Add-Ons

47:33 Getting Estradiol Prescribed

50:23 Suffering Mindset and Sexual Health

54:48 Active Surveillance Trial Ideas

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___________________________________⚠️ Disclaimer

This podcast is for educational purposes only and not medical advice. The views expressed are Dr. Geo’s and not those of his employer(s) or affiliated organizations. Use of this content is at your own risk. Geovanni Espinosa, N.D., assumes no liability for direct or indirect consequences, including economic loss, injury, illness, or death.

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