The Ultimate Human with Gary Brecka22 Syys

306. The Alzheimer's Drug With a 25% Brain Bleed Risk - Dr. David Perlmutter

You might think Alzheimer's starts in your 70s. Dr. David Perlmutter explains why it begins decades earlier, and how the p-tau 217 blood test flags risk long before symptoms appear. Gary Brecka and Dr. Perlmutter break down microglia, insulin resistance, pre-diabetes, APOE4, homocysteine, vitamin D, creatine and sleep, plus what the POINTER study showed about cognitive decline in metabolically compromised adults. CLICK HERE TO BECOME GARY’S VIP!: https://bit.ly/4ai0Xwg Get Dr. David Perlmutter’s book, “Brain Defenders”: https://bit.ly/4xvoYtY Listen to Dr. David Perlmutter on all your favorite platforms! YouTube: https://bit.ly/46rZjan Spotify: https://bit.ly/4dxPdZl Apple Podcasts: https://bit.ly/4dBz19u Connect with Dr. David Perlmutter Website: https://bit.ly/4yEhBBk YouTube: https://bit.ly/46rZjan Instagram: https://bit.ly/3VgElZH Facebook: https://bit.ly/4xvTC6v TikTok: https://bit.ly/4xXDcEM X: https://bit.ly/4xxJdal LinkedIn: https://bit.ly/4yfpNIF Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: “ULTIMATE20” FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: “ULTIMATE10” FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp CYMBIOTIKA: “BRECKACYM30” FOR 30% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET’S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 - Intro of the Show 01:33 - Grain Brain and ultra-processed carbohydrates 03:26 - Pre-diabetes decades before any symptoms 08:03 - Type 3 diabetes and insulin in the brain 11:48 - The fasting insulin level to target 14:08 - Immunometabolism and your microglial cells 16:12 - APOE4 as predisposition, not destiny 19:25 - Inflammation from the gut, mouth and air 25:50 - Aerobic vs resistance training for the brain 30:04 - Sarcopenia, myokines and BDNF 34:44 - Mitochondria and the TSPO brain scan 40:11 - The Tanzi, Ornish and POINTER trials 46:31 - Beta-amyloid drugs and the Cochrane data 55:00 - Sleep, the glymphatic system and insulin 58:25 - Creatine dosing and the creatinine confusion 1:03:52 - Vitamin D, VDR polymorphisms and tau 1:09:35 - Fish oil, DHA and the omega-3 study 1:12:48 - Homocysteine, B complex and MTHFR 1:18:43 - Red light, RNS60 and mitochondrial transplant 1:27:11 - Isolation, cortisol and oxytocin 1:32:58 - What it means to be an ultimate human Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

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309. How to Test Your Waist-to-Height Ratio

You might think being "skinny fat" is just about looking soft under your clothes, but a 2023 study found 26% of normal-weight men and 38% of normal-weight women actually had excess body fat their BMI ...

1 Loka 7min

308. Dr. Will Cole: Insulin Resistance Is Fueling Your Cellular Aging

You might think eating clean is enough to stay young, but new research says otherwise. One in five people over 50 already have one organ aging faster than the rest of their body. Dr. Will Cole joins G...

29 Syys 57min

307. Dr. Josh Axe, Dr. Will Cole & Taylor Dukes: Toxoplasma Gondii Is Linked to Brain Tumors

You can eat clean, do everything right, and still miss a brain tumor growing for years. Taylor Dukes found hers on a routine full-body scan, then shrank it in half before surgery using metabolic ketos...

24 Syys 33min

305 . Why CD38 Destroys NAD+ Faster Than You Produce It

NAD+ became a $4.5 billion industry of IV drips, patches, nasal sprays and powders almost overnight, with clinics charging $2,000 a bag to reverse your age and cure your hangover. Some of what you hav...

17 Syys 7min

304. Forrest Galante: Why Comfort Is What Actually Ages You

Wildlife biologist Forrest Galante has spent his life around animals that have constant access to food and never eat themselves into obesity or liver disease, and he argues that what humans do traces ...

15 Syys 1h 11min

303. The Truth About Anxiety and Your Vagus Nerve

You might think your anxiety is a mindset problem. It isn't. In this episode, human biologist Gary Brecka explains why chronic stress leaves your autonomic nervous system stuck in fight-or-flight, and...

10 Syys 11min

302. The Antibiotics That Reversed Alzheimer's Blood Marker - Dr. Richard Horowitz

Mold toxins show up in 90% of Dr. Richard Horowitz's chronically ill patients, and Lyme shows up in more. After 41 years and 13,000 cases, he just published the first documented reversal of an Alzheim...

8 Syys 1h 36min