186: NAD+, Sirtuins, and the 4 Root Causes of Aging

NAD+ is usually described as something you run out of. JP Errico explains why that's backwards: you don't stop making it, you burn through it — and inflammation is what's doing the burning.

In this episode, we cover what NAD+ actually does beyond energy production, why sirtuins can't function without it, and how CD38 on activated immune cells consumes NAD+ by the thousands of molecules. JP walks through SIRT1 and its control over NF-κB, PGC-1α and FOXO3; SIRT3's role in mitochondrial protein folding and heat shock proteins; and SIRT6's work in DNA damage repair.

We also get into a CD38 vaccine coming out of China, how your body packages the NAMPT recycling enzyme into exosomes and ships it to the cells that need it while you sleep, where urolithin A and methylene blue fit, and why no supplement can out-run a broken circadian rhythm.

JP closes with the four root causes of aging — mitochondrial electron transport chain malfunction, chronic NF-κB activation, AMPK and mTOR imbalance, and NAD+ depletion — and why every one of them is reversible.

In this episode, we discuss:

• Why NAD+ decline is a consumption problem, not a production problem
• PARP1, CD38, and what's actually draining the tank
• What sirtuins do, and why they stop working without NAD+
• SIRT1, SIRT3, SIRT6 — and which has the best longevity data
• NMN vs NR: why the debate matters less than you think
• Sleep, fasting, heat and exercise as the foundation
• The four reversible root causes of aging
• How perception changes whether a challenge ages you or strengthens you

Dr. Navaz Habib

Email: podcast@healthupgraded.com
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JP Errico
Instagram: https://www.instagram.com/thevnsguy/
LinkedIn: https://www.linkedin.com/in/jp-errico-097629aa