MS-Perspektive - The Multiple Sclerosis Podcast28 Loka

#189: New imaging in MS: understanding progression and finding better treatments | ECTRIMS 2026

How could new imaging in MS help us understand progression and develop better treatments?

In this episode, I explore key insights from Daniel Reich's MSToronto2026 lecture and related research. Learn what paramagnetic rim lesions can reveal about chronic inflammation, why MRI findings and biological treatment effects may tell different stories, and how imaging could help identify who benefits from emerging therapies.

I also discuss tolebrutinib, the HERCULES trial, and the disappointment surrounding the US regulatory setback, alongside its EU authorisation and important safety considerations.

Topics include:

Chronic inflammation and progression without relapses
Paramagnetic rim lesions and the exploratory BRaKe-MS study
Imaging biomarkers for better clinical trials
Tolebrutinib: evidence, limitations, and treatment access

This episode is my interpretation of the lecture and research, rather than an interview with Daniel Reich.

Research and resources

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See you soon and try to make the best out of your life,
Nele

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Jaksot(192)

#190: Living with multiple sclerosis. Gabriela's story and the "(un)seen faces of MS" Art Project

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#188: Jan Van Amstel on EMSP's Four-Year Presidency and the Future of MS Advocacy in Europe

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#186: Protecting nerve cells in multiple sclerosis: A new path toward neuroprotection with Prof. Manuel Friese

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7 Loka 43min

#185: Living with MS in Mexico – who gets diagnosed, who gets treated, and who gets left behind?

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30 Syys 36min

#184: MS treatment across the disease course – treat early, think long-term, don't give up too soon with Prof. Klaus Schmierer

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23 Syys 41min

#183: Silent progression in MS. Can we really detect it early?

Can we detect gradual MS progression before it becomes obvious? In this episode, I look at what current research can — and cannot — tell us about subtle worsening without an obvious relapse. The key d...

16 Syys 34min