#116 - Uric acid: A KEY cause of weight gain, diabetes, heart disease, and dementia (and simple steps to lower it) (Dr. David Perlmutter & Dr. Casey Means)

#116 - Uric acid: A KEY cause of weight gain, diabetes, heart disease, and dementia (and simple steps to lower it) (Dr. David Perlmutter & Dr. Casey Means)

Levels Chief Medical Officer, Dr. Casey Means, chatted with our advisor, Dr. David Perlmutter on the discovery of how the elevation of uric acid in the body is a causative mechanism in the development of metabolic diseases, and one of the key links between obesity, diabetes, heart disease, neurologic diseases like dementia, ADHD, fatty liver disease, and more.


Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠https://levels.link/wnl


They also covered:

  • The several mechanisms of how uric acid causes cellular dysfunction and insulin resistance, including oxidative stress, inflammation, and even preventing insulin from getting out of the blood stream effectively.
  • The evolutionary reasons why the metabolic dysfunction and weight gain caused by uric acid would have benefitted us historically in terms of low access to food and water, by letting us more easily pack on weight and raise blood pressure. And how we now live in an evolutionary-environmental mismatch where this survival mechanism is now hurting us in the face of caloric abundance.
  • The different dietary and environmental factors that generate uric acid, including fructose, purine rich foods and umami foods, dehydration, alcohol, and more.
  • The optimal levels for uric acid.
  • How uric acid impairs our hunger signals, drives us to eat, and even promotes risk taking behavior. We talked about how to reverse high uric acid levels as a way to unlock optimal health.

Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.

(04:23) - More than just gout

(06:17) - A causative role

(08:54) - The number one cause of death

(16:35) - Evolutionary environmental mismatch

(18:08) - High fructose corn syrup

(23:39) - The dangers of uric acid

(24:49) - Uric acid and dementia

(31:44) - Too much fructose

(42:43) - Erectile dysfunction and cardiovascular risk

(01:04:29) - No need to eat sugar

Transcripts & Show Notes

Jaksot(291)

#27 – Principles of effective communication (Michael Mizrahi & Sam Corcos)

#27 – Principles of effective communication (Michael Mizrahi & Sam Corcos)

Communication and communication platforms – specifically in a work setting – can lead to increased productivity, or can unfold as a distraction mechanism for urgency. Unfortunately, for most companies...

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#26 – Nutrition & Kids – A parent's perspective (Kelly LeVeque & Ben Grynol)

#26 – Nutrition & Kids – A parent's perspective (Kelly LeVeque & Ben Grynol)

For parents, feeding kids a balanced diet can feel like an uphill battle. People are surrounded by fast, convenient and highly processed food items, which can make the idea of 'meal time' easier to ge...

27 Syys 202150min

#25 – Understanding predictive markers of metabolic dysfunction (Dr. Sara Gottfried & Dr. Casey Means)

#25 – Understanding predictive markers of metabolic dysfunction (Dr. Sara Gottfried & Dr. Casey Means)

Dr. Sara Gottfried – a pioneer in health, research, and education – has seen more than 25,000 patients over the past two decades. She's a physician scientist, who graduated from Harvard Medical School...

23 Syys 20211h 23min

#24 – Perseverance, grit & performance (Mike Barwis & Ben Grynol)

#24 – Perseverance, grit & performance (Mike Barwis & Ben Grynol)

Mike Barwis has spent more than 30 years training professional athletes to be their best. But, it's not just physical performance that Mike focuses on during training sessions. Rather, he believes tha...

20 Syys 202157min

#23 – Mindset & metabolic health (Mike DiDonato & Ben Grynol)

#23 – Mindset & metabolic health (Mike DiDonato & Ben Grynol)

When Mike DiDonato was 19 years old, his father passed away suddenly. This experience changed the way that Mike looked at the world. When faced with adversity, Mike focused on mindset to take his well...

13 Syys 202140min

#22 - Building startup culture from the ground up | Marc Randolph, Co-Founder of Netflix & Sam Corcos

#22 - Building startup culture from the ground up | Marc Randolph, Co-Founder of Netflix & Sam Corcos

A startup needs to create and establish a company culture in the beginning in order for the team to thrive and grow as the company scales. Understandably, it may seem counterintuitive to focus on inta...

6 Syys 202150min

#21 – The Coke Challenge (Josh Clemente, Josh Mohrer & Ben Grynol)

#21 – The Coke Challenge (Josh Clemente, Josh Mohrer & Ben Grynol)

As a society, we're surrounded by many foods that have added sugar and are highly processed. However, when people see data that shows them the implications of consuming these items, they often change ...

30 Elo 202148min

#20 – Creating a movement through community (Dorothy Kilroy & Ben Grynol)

#20 – Creating a movement through community (Dorothy Kilroy & Ben Grynol)

Dorothy Kilroy, an Advisor to Levels, grew up in a small town in Ireland. As such, Dorothy was exposed to a tightly knit group of friends and acquaintances, which influenced her outlook on community g...

23 Elo 202143min

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