Antidepressant withdrawal with Tony Kendrick and Mark Horowitz
Deep Breath In27 Maalis 2023

Antidepressant withdrawal with Tony Kendrick and Mark Horowitz

The theory that depression is caused by serotonin deficiency has become embedded in our practice over the years, and can be a persuasive explanation of the condition for patients considering starting antidepressants. We talk to Tony Kendrick about the evidence (or lack thereof) to support this hypothesis, and what that means for the efficacy of antidepressants, particularly SSRIs. Later on, we speak to Mark Horowitz to discuss how to come off antidepressants safely, and manage withdrawal symptoms, and how to advise and support our patients as they gradually reduce, then stop, their medication. Our guests: Tony Kendrick is a retired GP, and NICE committee member for the 2022 guideline update on depression in adults. He is also a professor of Primary Medical Care at the University of Southampton. Mark Horowitz is a training psychiatrist, working as a clinical research fellow at North East NHS Trust, and as an honorary clinical research fellow at UCL, he is also the co-founder of outro.com. Further reading: ‘Antidepressants and the serotonin hypothesis of depression’. BMJ 2022;378:o1993 https://www.bmj.com/content/378/bmj.o1993

‘Stopping antidepressants’. Royal College of Psychiatrists. 2020. https://www.rcpsych.ac.uk/mental-health/treatments-and-wellbeing/stopping-antidepressants

Jaksot(75)

Musculoskeletal pain and osteoarthritis with Imran Sajid

Musculoskeletal pain and osteoarthritis with Imran Sajid

Musculoskeletal (MSK) pain and osteoarthritis are clinically common in general practice, but with the new draft NICE guideline on osteoarthritis (published in April 2022) recommending a move away from...

14 Syys 202252min

Retention with Pamela Curtis and GP trainees

Retention with Pamela Curtis and GP trainees

Despite the Conservation party manifesto for the 2019 general election promising to deliver 6,000 additional full-time equivalent GPs, worryingly, the NHS lost 717 FTE GPs between March 2019 and March...

24 Elo 202238min

Continuity with Martin Marshall and Emma Gladwinfield

Continuity with Martin Marshall and Emma Gladwinfield

In this week’s episode, we share our experiences of attending the recent RCGP Annual Conference, and our thoughts on the topics that were covered in the talks at this year’s event. We talk to RCGP Cha...

1 Elo 202244min

Adverse drug reactions with Anders Holt and Corine Ekhart

Adverse drug reactions with Anders Holt and Corine Ekhart

As more and more pharmaceutical products come onto the market, there are so many potential drug interactions, and adverse reactions, to bear in mind during a consultation in primary care. In this week...

11 Heinä 202242min

Violence against GPs  with Adam Janjua, Marcela Schilderman, and Anita Bignell

Violence against GPs with Adam Janjua, Marcela Schilderman, and Anita Bignell

A recent investigation, by The BMJ, showed a worrying increase in incidence of violence, directed to wards GPs, and reported to the police. In this episode of Deep Breath in, Tom and Jenny are joined ...

13 Kesä 202252min

Milk allergies with Nicola Brathwaite

Milk allergies with Nicola Brathwaite

Consultations about suspected cow’s milk protein allergies are quite common in primary care, but these allergies can be a challenge to diagnose, particularly as symptoms can manifest in many different...

30 Touko 202247min

Parosmia with Emily Woodroofe and Claire Hopkins

Parosmia with Emily Woodroofe and Claire Hopkins

Parosmia – a distorted sense of smell, and a delayed post-covid symptom – affects approximately 50% of people who experienced loss of smell during their initial covid infection, and it is currently at...

13 Touko 202242min

What’s in store for general practice in the UK

What’s in store for general practice in the UK

With the focus on covid, and the pressure on hospitals, it may be easy to overlook what’s happening in general practice in the UK - but changes are afoot. Our new health secretary Sajid Javid doesn’t ...

30 Huhti 202243min

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