Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

This week, I am joined by microbiologist Dr. Sarkis Mazmanian, the Luis B. and Nelly Soux Professor at Caltech, to discuss the microbiome's connection to human health—especially the gut-brain axis. Dr. Mazmanian discusses his research evolution from infectious diseases to the microbiome’s role in neurodevelopment and neurodegeneration, as well as how gut microbes influence neurological health, behavior, and conditions like Parkinson's, autism, and depression. He highlights the human gut microbe symbiosis, early-life microbial exposure's influence, and the adult microbiome's malleability. We explore microbiome-based therapeutics' potential, challenges in translating animal models to humans, personalized medicine's future, the microbiome's impact on drug efficacy, gut bacteria's influence on behaviors and cravings, and the importance of a healthy gut diet. Please enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: AG1: Get a FREE 1-year supply of Vitamin D3+K2 AND 5 free AG1 Travel Packs 👉drinkAG1.com/richroll InsideTracker: Use code RICHROLL at checkout and enjoy 10% OFF the InsideTracker Subscription and any plan 👉insidetracker.com/richroll On: 10% OFF your first order of high-performance shoes and apparel w/ code RICHROLL10👉on.com/richroll Roka: Unlock 20% OFF sunglasses & eyewear with code RICHROLL 👉roka.com/richroll Go Brewing: Use the code Rich Roll for 15% OFF my favorite non-alcoholic brews 👉gobrewing.com Squarespace: Use the offer code RichRoll to save 10% off your first purchase of a website or domain 👉Squarespace.com/RichRoll

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SOFI TUKKER On Unlikely EDM Superstardom, The Hard Business of Music, And The Athletic Art of Performance

SOFI TUKKER On Unlikely EDM Superstardom, The Hard Business of Music, And The Athletic Art of Performance

Sophie Hawley-Weld and Tucker Halpern, together known as SOFI TUKKER, defy every convention of electronic dance music.   This conversation explores their unlikely origin story—from D1 basketball capta...

27 Helmi 20252h 1min

The Mindful Body: Harvard’s Dr. Ellen Langer On The Power Of Mindfulness, How Thoughts Can Control Health, & Using Perspective To Lower Stress

The Mindful Body: Harvard’s Dr. Ellen Langer On The Power Of Mindfulness, How Thoughts Can Control Health, & Using Perspective To Lower Stress

Dr. Ellen Langer is Harvard’s first tenured female psychology professor, a pioneering researcher on the mind-body connection, and author of “The Mindful Body.”     This conversation explores the rad...

24 Helmi 20252h 23min

Happiness Is A Direction: Harvard Professor Arthur Brooks On Navigating Crisis, Building Better Relationships, Finding Meaning, & What Actually Makes Us Happy

Happiness Is A Direction: Harvard Professor Arthur Brooks On Navigating Crisis, Building Better Relationships, Finding Meaning, & What Actually Makes Us Happy

Arthur Brooks is a Harvard professor, behavioral scientist, and the world’s leading researcher on happiness.   This conversation explores the ineffable nature of happiness and meaning, explores why su...

17 Helmi 20252h 16min

Rivian Founder RJ Scaringe Is Building The Future: Leadership, Mindset, Innovation, & His Mission To Decarbonize Transportation

Rivian Founder RJ Scaringe Is Building The Future: Leadership, Mindset, Innovation, & His Mission To Decarbonize Transportation

RJ Scaringe is the visionary founder of Rivian, who turned his childhood obsession with engines into one of automotive history’s most audacious ventures.   This conversation explores the intractable c...

13 Helmi 20251h 23min

Fasting For Longevity: Valter Longo, PhD Shares Cutting-Edge Fasting Science & Optimal Nutrition Protocols For Lifespan Extension & Disease Prevention

Fasting For Longevity: Valter Longo, PhD Shares Cutting-Edge Fasting Science & Optimal Nutrition Protocols For Lifespan Extension & Disease Prevention

Dr. Valter Longo is a pioneering longevity researcher, Director of the USC Longevity Institute, and one of TIME’s 50 most influential people in healthcare. This conversation explores his groundbreaki...

10 Helmi 20251h 59min

Live Through Your Heart: Supermodel Elle Macpherson On Building Confidence, 20+ Years of Sobriety, Natural Wellness, & Learning to Trust Yourself

Live Through Your Heart: Supermodel Elle Macpherson On Building Confidence, 20+ Years of Sobriety, Natural Wellness, & Learning to Trust Yourself

Elle Macpherson is a record-breaking Sports Illustrated cover model, pioneering entrepreneur, and the ineffable force behind the global wellness empire WelleCo.   This conversation explores the inters...

3 Helmi 20251h 57min

Win The Inside Game: High Performance Psychology, Busting Fitness Myths, & Getting Unstuck With Elite Coach Steve Magness

Win The Inside Game: High Performance Psychology, Busting Fitness Myths, & Getting Unstuck With Elite Coach Steve Magness

Steve Magness is a renowned performance expert and author of “Win the Inside Game,” who has dedicated his career to examining why we often calcify into patterns that no longer serve us.   This convers...

30 Tammi 20252h 16min

The 5 Types of Wealth: Sahil Bloom On Why Time, Friends, Mind & Body Always Come Before Money

The 5 Types of Wealth: Sahil Bloom On Why Time, Friends, Mind & Body Always Come Before Money

Sahil Bloom is a Stanford athlete turned finance executive whose life took an unexpected turn when a friend's observation catalyzed a complete reevaluation of success. This conversation explores his ...

27 Tammi 20252h 2min

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