Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

This week, I am joined by microbiologist Dr. Sarkis Mazmanian, the Luis B. and Nelly Soux Professor at Caltech, to discuss the microbiome's connection to human health—especially the gut-brain axis. Dr. Mazmanian discusses his research evolution from infectious diseases to the microbiome’s role in neurodevelopment and neurodegeneration, as well as how gut microbes influence neurological health, behavior, and conditions like Parkinson's, autism, and depression. He highlights the human gut microbe symbiosis, early-life microbial exposure's influence, and the adult microbiome's malleability. We explore microbiome-based therapeutics' potential, challenges in translating animal models to humans, personalized medicine's future, the microbiome's impact on drug efficacy, gut bacteria's influence on behaviors and cravings, and the importance of a healthy gut diet. Please enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: AG1: Get a FREE 1-year supply of Vitamin D3+K2 AND 5 free AG1 Travel Packs 👉drinkAG1.com/richroll InsideTracker: Use code RICHROLL at checkout and enjoy 10% OFF the InsideTracker Subscription and any plan 👉insidetracker.com/richroll On: 10% OFF your first order of high-performance shoes and apparel w/ code RICHROLL10👉on.com/richroll Roka: Unlock 20% OFF sunglasses & eyewear with code RICHROLL 👉roka.com/richroll Go Brewing: Use the code Rich Roll for 15% OFF my favorite non-alcoholic brews 👉gobrewing.com Squarespace: Use the offer code RichRoll to save 10% off your first purchase of a website or domain 👉Squarespace.com/RichRoll Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Malcolm Gladwell & Chris Chavez Think We're Selling Running All Wrong

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Malcolm Gladwell is a staff writer at The New Yorker, bestselling author, and podcaster. Chris Chavez is a journalist, podcaster, and the founder of CITIUS MAG. I just passed a thousand episodes, whi...

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What Are You Actually Capable Of? Mark Dowdle On Winning A 306 Mile Backyard Ultra

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Mark Dowdle is an endurance athlete and former football and lacrosse player. This conversation explores the intersection of endurance and identity, digging into the stories we tell ourselves about wh...

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Episode 1,000: Rich & Julie Piatt Celebrate By Going Back To Where It All Began

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This is the 1,000th episode of the podcast. Insane. To mark it, Julie and I take it back to the start. We recap the origin story of this show. A creative experiment, born in a yurt on a Kauai mango f...

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Thrilling Tales Of Modern Men: Danny McBride On Ego, Grievance & The Stories Men Tell Themselves

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Danny McBride is the writer, actor, and producer behind “Eastbound & Down,” “Vice Principals,” and “The Righteous Gemstones.” For 30 years, he's satirized the aggrieved modern male, the guy who grew ...

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Dr. Kelly Starrett is a physical therapist, New York Times bestselling author, and co-founder of The Ready State. This conversation explores human performance and a wellness culture that's become a k...

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What Happened To The Vegan Movement? Rich & Simon Hill On The Rise & Fall Of Plant-Based Eating

What Happened To The Vegan Movement? Rich & Simon Hill On The Rise & Fall Of Plant-Based Eating

By 2020, veganism wasn't a fringe choice. It was mainstream. A few years later, the momentum faded. So what happened? I sit down with nutrition scientist Simon Hill for an honest autopsy – the overhy...

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Radiohead’s Ed O’Brien on Depression, Trauma & Finding Light Again

Radiohead’s Ed O’Brien on Depression, Trauma & Finding Light Again

Ed O'Brien is a member of Radiohead and the artist behind his new solo album "Blue Morpho." This conversation explores the intersection of creativity and mental health, and the ways transformation so...

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Fulfillment Maxxing: Why Offline Is The New Online & How to Feel Alive Again

Fulfillment Maxxing: Why Offline Is The New Online & How to Feel Alive Again

I think a lot of us are quietly struggling with some version of self-obsession right now. So today I want to talk about a different way to think about all of it: fulfillment maxxing. I get into the ...

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