Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

This week, I am joined by microbiologist Dr. Sarkis Mazmanian, the Luis B. and Nelly Soux Professor at Caltech, to discuss the microbiome's connection to human health—especially the gut-brain axis. Dr. Mazmanian discusses his research evolution from infectious diseases to the microbiome’s role in neurodevelopment and neurodegeneration, as well as how gut microbes influence neurological health, behavior, and conditions like Parkinson's, autism, and depression. He highlights the human gut microbe symbiosis, early-life microbial exposure's influence, and the adult microbiome's malleability. We explore microbiome-based therapeutics' potential, challenges in translating animal models to humans, personalized medicine's future, the microbiome's impact on drug efficacy, gut bacteria's influence on behaviors and cravings, and the importance of a healthy gut diet. Please enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: AG1: Get a FREE 1-year supply of Vitamin D3+K2 AND 5 free AG1 Travel Packs 👉drinkAG1.com/richroll InsideTracker: Use code RICHROLL at checkout and enjoy 10% OFF the InsideTracker Subscription and any plan 👉insidetracker.com/richroll On: 10% OFF your first order of high-performance shoes and apparel w/ code RICHROLL10👉on.com/richroll Roka: Unlock 20% OFF sunglasses & eyewear with code RICHROLL 👉roka.com/richroll Go Brewing: Use the code Rich Roll for 15% OFF my favorite non-alcoholic brews 👉gobrewing.com Squarespace: Use the offer code RichRoll to save 10% off your first purchase of a website or domain 👉Squarespace.com/RichRoll

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The King of Moab: Ultrarunner Max Jolliffe On Winning Moab 240, Recovery From Heroin Addiction & Why Suffering Is His Greatest Teacher

The King of Moab: Ultrarunner Max Jolliffe On Winning Moab 240, Recovery From Heroin Addiction & Why Suffering Is His Greatest Teacher

Max Jolliffe is the Moab 240 course record holder, elite ultrarunner, and one of endurance sport's more unlikely origin stories. This conversation explores Max's multi-generational family history wit...

6 Huhti 1h 40min

Rich Speaks On Tiger Woods, Addiction & The Wounds That Fame Can't Heal

Rich Speaks On Tiger Woods, Addiction & The Wounds That Fame Can't Heal

Tiger Woods' recent DUI arrest has everyone asking why. I have some thoughts on that. And some personal experience. In this solo episode, I draw on my own history with addiction to illuminate what's ...

2 Huhti 37min

Arthur Brooks On The Crisis Of Meaning & How To Actually Find It

Arthur Brooks On The Crisis Of Meaning & How To Actually Find It

Arthur Brooks is a Harvard professor, bestselling author, and one of the world's leading authorities on human happiness. This conversation explores what he calls a psychogenic epidemic — a crisis of ...

30 Maalis 2h 4min

Decoding the New U.S. Dietary Guidelines with Simon Hill: What They Got Right, Wrong & Why It Matters

Decoding the New U.S. Dietary Guidelines with Simon Hill: What They Got Right, Wrong & Why It Matters

Simon Hill is a nutritionist, physiotherapist, and host of “The Proof” podcast. We dig into the newly released U.S. Dietary Guidelines: what changed, what the evidence actually supports, and how the ...

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Future-Proof Your Brain from Dementia & The Lifestyle Levers That Keep You Sharp with Neuroscientist Dr. Tommy Wood

Future-Proof Your Brain from Dementia & The Lifestyle Levers That Keep You Sharp with Neuroscientist Dr. Tommy Wood

Dr. Tommy Wood is a neuroscientist, physician, associate professor at the University of Washington, and the author of “The Stimulated Mind.” I came into this one with a lot on my mind. My mother has ...

23 Maalis 2h 14min

Stanford Professors Bill Burnett & Dave Evans On How To Design A Meaningful Life

Stanford Professors Bill Burnett & Dave Evans On How To Design A Meaningful Life

Bill Burnett and Dave Evans created perhaps the most popular course at Stanford, "Designing Your Life," and co-authored the book "How to Live a Meaningful Life." This conversation explores the inters...

16 Maalis 2h

Sobriety, Relapse & Redemption: Rich Speaks On Shia Labeouf & What True Accountability Looks Like

Sobriety, Relapse & Redemption: Rich Speaks On Shia Labeouf & What True Accountability Looks Like

This is my first solo episode — and honestly, out of my comfort zone. Which is exactly why I needed to do it. The recent Channel 5 interview between Shia LaBeouf and Andrew Callaghan went wildly vira...

12 Maalis 56min

Ken Rideout On Why Everything You Want Is On The Other Side Of Hard

Ken Rideout On Why Everything You Want Is On The Other Side Of Hard

Ken Rideout is a masters world champion marathon runner, recovering opioid addict, and the author of the new memoir, “Everything You Want Is on the Other Side of Hard.” This conversation explores the...

9 Maalis 1h 51min

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