Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis

This week, I am joined by microbiologist Dr. Sarkis Mazmanian, the Luis B. and Nelly Soux Professor at Caltech, to discuss the microbiome's connection to human health—especially the gut-brain axis. Dr. Mazmanian discusses his research evolution from infectious diseases to the microbiome’s role in neurodevelopment and neurodegeneration, as well as how gut microbes influence neurological health, behavior, and conditions like Parkinson's, autism, and depression. He highlights the human gut microbe symbiosis, early-life microbial exposure's influence, and the adult microbiome's malleability. We explore microbiome-based therapeutics' potential, challenges in translating animal models to humans, personalized medicine's future, the microbiome's impact on drug efficacy, gut bacteria's influence on behaviors and cravings, and the importance of a healthy gut diet. Please enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today’s Sponsors: AG1: Get a FREE 1-year supply of Vitamin D3+K2 AND 5 free AG1 Travel Packs 👉drinkAG1.com/richroll InsideTracker: Use code RICHROLL at checkout and enjoy 10% OFF the InsideTracker Subscription and any plan 👉insidetracker.com/richroll On: 10% OFF your first order of high-performance shoes and apparel w/ code RICHROLL10👉on.com/richroll Roka: Unlock 20% OFF sunglasses & eyewear with code RICHROLL 👉roka.com/richroll Go Brewing: Use the code Rich Roll for 15% OFF my favorite non-alcoholic brews 👉gobrewing.com Squarespace: Use the offer code RichRoll to save 10% off your first purchase of a website or domain 👉Squarespace.com/RichRoll

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Proof Of Life: Jennifer Pastiloff On Silencing Your Inner Critic, Transforming Childhood Trauma, & The Radical Power Of Self-Acceptance

Proof Of Life: Jennifer Pastiloff On Silencing Your Inner Critic, Transforming Childhood Trauma, & The Radical Power Of Self-Acceptance

Jennifer Pastiloff is a bestselling author and creator of the viral "On Being Human" movement. This conversation explores her journey from childhood trauma to radical self-acceptance, her concept of ...

21 Heinä 20252h 4min

Your Brain On Sleep: A Compilation On Brain States, Biological Rhythms & Why Sleep Deprivation Is Sabotaging Your Life

Your Brain On Sleep: A Compilation On Brain States, Biological Rhythms & Why Sleep Deprivation Is Sabotaging Your Life

This is the ultimate sleep compilation featuring Bryan Johnson, Andrew Huberman, Matthew Walker, and Simon Hill. These conversations explore the mythology of sleep deprivation, why hustle culture is ...

17 Heinä 202559min

The Metrics That Matter: Whoop Founder Will Ahmed On Why Most People Get Fitness Wrong, Why Recovery Beats Intensity, & The Science of Human Potential

The Metrics That Matter: Whoop Founder Will Ahmed On Why Most People Get Fitness Wrong, Why Recovery Beats Intensity, & The Science of Human Potential

Will Ahmed is the founder and CEO of Whoop, the wearable device that's quietly revolutionizing how elite athletes and everyday people optimize their bodies. This conversation explores Will’s journey ...

14 Heinä 20251h 58min

World Champion John John Florence On The Mindset of Elite Sport, Walking Away At His Peak & Why True Mastery Begins With Surrender

World Champion John John Florence On The Mindset of Elite Sport, Walking Away At His Peak & Why True Mastery Begins With Surrender

John John Florence is a three-time World Surf League Champion and one of the most naturally gifted surfers of his generation. This conversation explores John John's decision to step away from competi...

7 Heinä 20251h 44min

Gut Health Compilation: Leading Experts On Fiber, Inflammation, Cancer Survival, & How Your Gut Predicts Your Future Health

Gut Health Compilation: Leading Experts On Fiber, Inflammation, Cancer Survival, & How Your Gut Predicts Your Future Health

Leading microbiome researchers Will Bulsiewicz, Tim Spector, and Robynne Chutkan share discoveries that are rewriting health science. This compilation explores how 5 grams of fiber can boost cancer s...

3 Heinä 20251h 6min

The Science Of Happiness: Dr. Laurie Santos Shares Evidence-Based Tools For Genuine Joy, Why We Chase The Wrong Things & What Actually Creates Well-Being

The Science Of Happiness: Dr. Laurie Santos Shares Evidence-Based Tools For Genuine Joy, Why We Chase The Wrong Things & What Actually Creates Well-Being

Dr. Laurie Santos is a renowned psychology professor at Yale University and creator of the most popular course in Yale's history: "Psychology and the Good Life." This conversation explores why our in...

30 Kesä 20252h 26min

Ethan Suplee On Shedding 300 Pounds, Ditching Drugs & What It Really Takes To Transform Your Life

Ethan Suplee On Shedding 300 Pounds, Ditching Drugs & What It Really Takes To Transform Your Life

Ethan Suplee is a renowned actor known for My Name is Earl, American History X, and The Wolf of Wall Street. This conversation explores the intersection of trauma, food addiction, and the false narra...

23 Kesä 20252h 15min

ROLL ON: Embracing Stillness, Recovering From Surgery & Going Slow To Go Slow

ROLL ON: Embracing Stillness, Recovering From Surgery & Going Slow To Go Slow

Roll On returns! Brace yourselves!  Adam Skolnick and I catch up on spinal fusion surgery, going slow to go slow, and what happens when the universe finally gets your attention.  On tap: recovery r...

19 Kesä 20251h 22min

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