Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jaksot(1361)

CB-03-01 Review (Breezula) | Is It The Cure For Hair Loss?

CB-03-01 Review (Breezula) | Is It The Cure For Hair Loss?

I finally got around to trying CB-03-01. I had heard varying opinions on its therapeutic promise in the community, but at the end of the day I had to do a CB-03-01 review myself to see if this compound is superior to other alternatives we already have at our disposal.… Learn more about your ad choices. Visit megaphone.fm/adchoices

20 Loka 20198min

Derek & Chris React To His First Steroid Cycle Logged On Bodybuilding.com

Derek & Chris React To His First Steroid Cycle Logged On Bodybuilding.com

Chris and I met up in Vegas recently and filmed a few videos. In this one, Chris and I go into the depths of the bodybuilding.com forums to find his first prohormone cycle log he made when he was 20 years old (almost 20 years ago when he was heavily into bodybuilding).… Learn more about your ad choices. Visit megaphone.fm/adchoices

20 Loka 201933min

Fouad Abiad And The Research Station Podcast Review With Analysis

Fouad Abiad And The Research Station Podcast Review With Analysis

Fouad Abiad recently had Mike from “The Research Station” on his podcast to discuss bodybuilding pharmacology. While I agree with many of the concepts Mike presented, there are a handful which I felt were incorrect and should be addressed. [1:16] Addressing The Statement: “The Body Can Only Manage 125 MG Of Testosterone Per Day” [7:42] Are Subcutaneous Injections Less Stable Than Intramuscular Injections? … Learn more about your ad choices. Visit megaphone.fm/adchoices

20 Loka 201956min

The Reported Side Effects Of SARMs In Human Trials

The Reported Side Effects Of SARMs In Human Trials

In general, there are two camps of individuals who have polar opposite views on the promise of SARMs. One camp views them as weak alternatives to Steroids with just as many side effects. The other camp hypes SARMs up as compounds that are nearly as effective (or just as effective) as Steroids, but with far less severe side effects.… Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Loka 201920min

Ashton Kutcher Used Dutasteride For A Decade To Prevent Hair Loss

Ashton Kutcher Used Dutasteride For A Decade To Prevent Hair Loss

Learn more about your ad choices. Visit megaphone.fm/adchoices

17 Loka 20196min

How To Test If Your Hair Loss Is Male Pattern Baldness Or Telogen Effluvium

How To Test If Your Hair Loss Is Male Pattern Baldness Or Telogen Effluvium

This article will detail a quick and easy way to determine whether or not you are experiencing male pattern baldness or telogen effluvium (temporary shedding). If you've seen my other posts discussing hair loss, you probably already know that there is a difference between follicular miniaturization triggered by androgens, and shedding triggered by nutritional deficiencies, hormonal fluctuations, environmental factors, toxins, allergens, hypothyroidism, radiation therapy, and other stressors.… Learn more about your ad choices. Visit megaphone.fm/adchoices

9 Loka 20198min

How To Get More Vascular – Practical Tips To Make The Veins In Your Arms POP

How To Get More Vascular – Practical Tips To Make The Veins In Your Arms POP

There are a handful of strategies that can be implemented to get more vascular via significantly increasing nitric oxide, vasodilation, blood flow and muscle detail. How do you get your bicep vein to really pop? How do you force your veins against the surface of the skin and get that paper-thin skin look?… Learn more about your ad choices. Visit megaphone.fm/adchoices

6 Loka 201911min

How Many MCG Of T3 And T4 Do You Naturally Produce? | The Answer Might Surprise You

How Many MCG Of T3 And T4 Do You Naturally Produce? | The Answer Might Surprise You

Instead of taking an arbitrary amount of T3 and T4, it would be wise to address potential dietary deficiencies and autoimmune triggers first and foremost. However, if exogenous T3 and T4 use is something you are dead set on, or you already use one or the other, you would benefit from knowing what healthy endogenous production actually equates to.… Learn more about your ad choices. Visit megaphone.fm/adchoices

5 Loka 20195min

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