Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jaksot(1361)

My Blood Work On 100 MG Testosterone Per Week (With Accurate LC/MS-MS)

My Blood Work On 100 MG Testosterone Per Week (With Accurate LC/MS-MS)

I recently lowered my weekly TRT dose down to 100 mg Testosterone Propionate split into every day subcutaneous administrations with an insulin pin. Micro-dosing every day results in the most stable blood serum concentrations possible, less aromatization, and more free testosterone.… Learn more about your ad choices. Visit megaphone.fm/adchoices

3 Loka 20199min

Julian Smith Bulked For 6 Years Straight | Should You Too?

Julian Smith Bulked For 6 Years Straight | Should You Too?

Julian Smith claims he bulked for six years straight. He attributes the majority of his success/his accrual of lean muscle mass to this extended bulk phase he did that lasted six years. Basically, he walked around fatter than he needed to be for six years with the logic that he needed to be in a surplus for over a half a decade straight and walk around at 20%+ to maximize his bodybuilding progress.… Learn more about your ad choices. Visit megaphone.fm/adchoices

3 Loka 20196min

Is Post Finasteride Syndrome Real? | How To Diagnose And Reverse It

Is Post Finasteride Syndrome Real? | How To Diagnose And Reverse It

I believe that interpreting blood work correctly and implementing an appropriate lifestyle and/or pharmacological protocol can reverse Post Finasteride Syndrome. Post Finasteride Syndrome describes negative side effects caused by Finasteride that persist long-term, even after discontinuing its use. Finasteride-induced side effects can be very real.… Learn more about your ad choices. Visit megaphone.fm/adchoices

28 Syys 201921min

How Calum Von Moger Gained His Muscle Back So Fast | Banked Myonuclei

How Calum Von Moger Gained His Muscle Back So Fast | Banked Myonuclei

Calum Von Moger Injuries Calum Von Moger tore his bicep in 2017 which took him out of commission for several months. View this post on Instagram DONT TRY THIS! last night I had this crazy idea that me and @cbum_ should attempt a 400lb barbell curl. … Learn more about your ad choices. Visit megaphone.fm/adchoices

24 Syys 20194min

Should You Use Mouth Tape For Mewing If You Have Sleep Apnea? What Body Position Is Ideal?

Should You Use Mouth Tape For Mewing If You Have Sleep Apnea? What Body Position Is Ideal?

Mouth Tape For Mewing Using mouth tape for Mewing has started to pick up in popularity as many are starting to learn about the potential ramifications that mouth breathing can have cosmetically, and on overall health. It's one thing to consciously force yourself to Mew while you're awake, but Mewing while you are sleeping can be nearly impossible if you are not forcing yourself to breathe through your nose.… Learn more about your ad choices. Visit megaphone.fm/adchoices

22 Syys 20192min

How To Tell If You Are Mewing Correctly | ENT Doctor’s Opinion

How To Tell If You Are Mewing Correctly | ENT Doctor’s Opinion

Are you Mewing correctly? While I've watched dozens of instructional videos and read through several articles to make sure I'm not wasting my time with what I thought was the correct way, I wanted to get my ear nose and throat specialist's input to see if it lines up with everything I've learned to date.… Learn more about your ad choices. Visit megaphone.fm/adchoices

22 Syys 20192min

Mewing While Exercising And Sleeping | Is It Necessary? | ENT Doctor’s Opinion

Mewing While Exercising And Sleeping | Is It Necessary? | ENT Doctor’s Opinion

My conversation with my ear nose and throat (ENT) specialist continued where we subsequently talked about the potential ramifications mouth-breathing can have on the craniofacial development, and its potential implications relating to my sleep apnea. About a year ago, I started to dive down the rabbit hole of mouth breathing vs nasal breathing with “proper” tongue posture.… Learn more about your ad choices. Visit megaphone.fm/adchoices

22 Syys 20191min

Turbinate Reduction Vs Deviated Septum Surgery For Mewing? | ENT Doctor’s Opinion

Turbinate Reduction Vs Deviated Septum Surgery For Mewing? | ENT Doctor’s Opinion

Is turbinate reduction or deviated septum surgery for mewing effective? In a previous discussion we have talked about whether or not my deviated septum or inflamed turbinates is the cause of my mouth breathing. My ear nose and throat (ENT) doctor outlined how septal deviation and inflammation of turbinates compounds inhibition of nasal circulation.… Learn more about your ad choices. Visit megaphone.fm/adchoices

22 Syys 20194min

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