Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jaksot(1360)

Do SARMs Cause Hair Loss? | Can SARMs Prevent Hair Loss?

Do SARMs Cause Hair Loss? | Can SARMs Prevent Hair Loss?

Do SARMs Cause Hair Loss? One of the first questions many have regarding SARMs is “Do SARMs cause hair loss?” All SARMs can cause hair loss. The extent to which they can cause it is based upon their own inherent tissue selectivity and androgenicity.… Learn more about your ad choices. Visit megaphone.fm/adchoices

18 Maalis 201912min

Dutasteride With Testosterone For Hair Loss Prevention | Hair Loss Experiment Follow-Up

Dutasteride With Testosterone For Hair Loss Prevention | Hair Loss Experiment Follow-Up

How Relevant Is DHT To Hair Loss? The first thing I want to make clear in regards to my Dutasteride and Testosterone experiment is that DHT is the worst hormone in your body for your hair. I don’t want anyone to misinterpret my videos and articles exhibiting the androgenicity of Testosterone as disregarding how bad DHT is.… Learn more about your ad choices. Visit megaphone.fm/adchoices

15 Maalis 201942min

Food Is The Most Anabolic Part Of Any Steroid Cycle

Food Is The Most Anabolic Part Of Any Steroid Cycle

Food Is More Important Than Your Steroid Cycle In Bodybuilding Over-analyzing drug combinations and steroid cycle protocols in general is something I see on a daily basis. I receive a lot of messages over email, comments on my blog, DM’s on Instagram, Facebook messages, etc.… Learn more about your ad choices. Visit megaphone.fm/adchoices

8 Helmi 20194min

Does Finasteride Lower Testosterone Levels?

Does Finasteride Lower Testosterone Levels?

Finasteride Myths A very common misconception about Finasteride (also known as Propecia and Proscar) is the belief that it lowers testosterone levels. This is typically derived from the fact that Finasteride can lower libido and cause erectile dysfunction in a minority of users [R, R, R].… Learn more about your ad choices. Visit megaphone.fm/adchoices

1 Helmi 20196min

Mewing For Facial Structure And Sleep Apnea Treatment – My Mewing Log

Mewing For Facial Structure And Sleep Apnea Treatment – My Mewing Log

What Is Mewing And Orthotropics? If you've never heard of Mewing, it's a concept named after Mike Mew and John Mew that stands for the proper way to posture yourself while you breathe, swallow, chew, and essentially anything that has to do with your face.… Learn more about your ad choices. Visit megaphone.fm/adchoices

15 Tammi 201911min

There Are 2 Types Of Hair Loss | Male Pattern Baldness (Permanent) Vs Shedding (Temporary)

There Are 2 Types Of Hair Loss | Male Pattern Baldness (Permanent) Vs Shedding (Temporary)

What you need to understand about hair loss is that there are two types. One is male pattern baldness, which is the acceleration of hair permanently being lost via androgen miniaturization at the hair follicle, which is what most guys are experiencing.… Learn more about your ad choices. Visit megaphone.fm/adchoices

7 Tammi 201912min

MENT (Trestolone) Experiment – Is It Hair Loss Safe? | Potential HRT Alternative

MENT (Trestolone) Experiment – Is It Hair Loss Safe? | Potential HRT Alternative

The potent synthetic androgen Trestolone, also known as 7α-methyl-19-norTestosterone (MENT), does not require 5α-reduction to exert its' maximal androgenic effects. It is an Anabolic Androgenic Steroid (AAS), which has been under development for potential use as a form of hormonal birth control for men and in androgen replacement therapy for low Testosterone levels in men but has never been approved for clinical usage.… Learn more about your ad choices. Visit megaphone.fm/adchoices

4 Tammi 201915min

Cholesterol & Inflammation Eating 1 Pound Of Red Meat Per Day – Vertical Diet Log Week 7-14

Cholesterol & Inflammation Eating 1 Pound Of Red Meat Per Day – Vertical Diet Log Week 7-14

If you read my last update, basically what had happened was I delved into my blood work and talked about my cholesterol being a big concern. I’ve been following the Vertical Diet to a tee exactly how Stan would advise it, and was eating one pound of lean 90/10 ground bison per day, 4 eggs per day, long story short I was hitting all the diet goals outlined in the book relative to my body’s individual specific energy requirements for my current goals.… Learn more about your ad choices. Visit megaphone.fm/adchoices

3 Tammi 201917min

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