Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jaksot(1360)

How To Store RU58841 Mixed Solutions And RU58841 Raw Powder

How To Store RU58841 Mixed Solutions And RU58841 Raw Powder

If you don’t already know what RU58841 is, it is a non-steroidal experimental anti-androgen, which is intended for use as a topical treatment for acne and androgenic alopecia (male pattern baldness). If you haven’t read my overview article on RU58841 check it out here: RU58841 There are a lot of myths surrounding the proper storage of this research chemical, and I’m going to quickly clarify every thing for you in this quick article.… Learn more about your ad choices. Visit megaphone.fm/adchoices

8 Marras 20164min

Modafinil – What You Can ACTUALLY Expect (It’s Not Like Limitless)

Modafinil – What You Can ACTUALLY Expect (It’s Not Like Limitless)

I have had a prescription for Modafinil for a few years now, and I have quite the thorough experience with the stuff to say the least. Before you jump to the conclusion that I have (or faked having) ADD/ADHD symptoms to get a prescription, let me preface this by saying that Modafinil IS NOT a drug prescribed to treat attention deficit disorder symptoms.… Learn more about your ad choices. Visit megaphone.fm/adchoices

21 Loka 201612min

RAD140 (Testolone) – Results, Clinical Trials & Reviews

RAD140 (Testolone) – Results, Clinical Trials & Reviews

RAD140 is a selective androgen receptor modulator (SARM) currently under development for potential use in treating muscle wasting disorders and hormone-receptor positive breast cancer. For those that are just here find out where to buy accurately dosed, third party tested RAD140, these are the only companies I currently use for my own personal research: (Greater Than 99% Purity: FTIR, HPLC, GC-MS, LC-MS & NMR Tested) Proven Peptides – 10% off coupon code “DC10” Science.bio… Learn more about your ad choices. Visit megaphone.fm/adchoices

4 Loka 201628min

S4 (Andarine): Results, Clinical Trials & Reviews

S4 (Andarine): Results, Clinical Trials & Reviews

S4 (Andarine) is an abandoned selective androgen receptor modulator (SARM) that was intended mainly for treatment of benign prostatic hypertrophy. For those that are just here find out where to buy accurately dosed, third party tested S4, these are the only companies I currently use for my own personal research: (Greater Than 99% Purity: FTIR, HPLC, GC-MS, LC-MS & NMR Tested) Proven Peptides – 10% off coupon code “DC10” Science.bio… Learn more about your ad choices. Visit megaphone.fm/adchoices

20 Heinä 201644min

Cardarine (GW501516) – Results, Clinical Trials & Reviews

Cardarine (GW501516) – Results, Clinical Trials & Reviews

Cardarine (GW501516) is a PPARδ receptor agonist that was developed for the potential treatment of metabolic diseases and cardiovascular diseases [R, R]. Cardarine is purported by many recreational users to be the most effective endurance boosting chemical on the planet right now.… Learn more about your ad choices. Visit megaphone.fm/adchoices

31 Touko 201629min

LGD-4033 (Ligandrol) – Results, Clinical Trials & Reviews

LGD-4033 (Ligandrol) – Results, Clinical Trials & Reviews

LGD-4033 is a selective androgen receptor modulator (SARM) currently being researched for its potential applications in the clinical treatment of muscle wasting, osteoporosis and other related conditions. LGD-4033 is purported to be the most potent SARM currently in clinical trials, with its data exhibiting the most favorable ratio of anabolic activity relative to androgenic activity.… Learn more about your ad choices. Visit megaphone.fm/adchoices

21 Touko 201641min

MK-677 (Ibutamoren) – Results, Clinical Trials & Reviews

MK-677 (Ibutamoren) – Results, Clinical Trials & Reviews

Ibutamoren (developmental code name MK-677) is an orally-active growth hormone secretagogue and ghrelin receptor agonist being researched as a potential treatment for growth hormone deficiency and sarcopenia [R, R, R, R, R]. For those that are just here find out where to buy accurately dosed, third party tested MK-677, these are the only companies I currently use for my own personal research: (Greater Than 99% Purity: FTIR, HPLC, GC-MS, LC-MS & NMR Tested) Proven Peptides – 10% off coupon code “DC10” Science.bio… Learn more about your ad choices. Visit megaphone.fm/adchoices

12 Touko 201638min

Ostarine (MK-2866; Enobosarm) – Results, Clinical Trials & Reviews

Ostarine (MK-2866; Enobosarm) – Results, Clinical Trials & Reviews

Ostarine is the most well known and extensively studied selective androgen receptor modulator (SARM) right now. It is categorized as a SARM because of its unique selectivity at the androgen receptor where it exhibits a significant amount of anabolic activity in the body relative to androgenic activity.… Learn more about your ad choices. Visit megaphone.fm/adchoices

28 Maalis 201626min

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