#181 – Laura Deming on the science that could keep us healthy in our 80s and beyond

#181 – Laura Deming on the science that could keep us healthy in our 80s and beyond

"The question I care about is: What do I want to do? Like, when I'm 80, how strong do I want to be? OK, and then if I want to be that strong, how well do my muscles have to work? OK, and then if that's true, what would they have to look like at the cellular level for that to be true? Then what do we have to do to make that happen? In my head, it's much more about agency and what choice do I have over my health. And even if I live the same number of years, can I live as an 80-year-old running every day happily with my grandkids?" — Laura Deming

In today’s episode, host Luisa Rodriguez speaks to Laura Deming — founder of The Longevity Fund — about the challenge of ending ageing.

Links to learn more, summary, and full transcript.

They cover:

  • How lifespan is surprisingly easy to manipulate in animals, which suggests human longevity could be increased too.
  • Why we irrationally accept age-related health decline as inevitable.
  • The engineering mindset Laura takes to solving the problem of ageing.
  • Laura’s thoughts on how ending ageing is primarily a social challenge, not a scientific one.
  • The recent exciting regulatory breakthrough for an anti-ageing drug for dogs.
  • Laura’s vision for how increased longevity could positively transform society by giving humans agency over when and how they age.
  • Why this decade may be the most important decade ever for making progress on anti-ageing research.
  • The beauty and fascination of biology, which makes it such a compelling field to work in.
  • And plenty more.

Chapters:

  • The case for ending ageing (00:04:00)
  • What might the world look like if this all goes well? (00:21:57)
  • Reasons not to work on ageing research (00:27:25)
  • Things that make mice live longer (00:44:12)
  • Parabiosis, changing the brain, and organ replacement can increase lifespan (00:54:25)
  • Big wins the field of ageing research (01:11:40)
  • Talent shortages and other bottlenecks for ageing research (01:17:36)

Producer and editor: Keiran Harris
Audio Engineering Lead: Ben Cordell
Technical editing: Simon Monsour and Milo McGuire
Additional content editing: Katy Moore and Luisa Rodriguez
Transcriptions: Katy Moore

Jaksot(326)

Luisa and Keiran on free will, and the consequences of never feeling enduring guilt or shame

Luisa and Keiran on free will, and the consequences of never feeling enduring guilt or shame

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#202 – Venki Ramakrishnan on the cutting edge of anti-ageing science

#202 – Venki Ramakrishnan on the cutting edge of anti-ageing science

"For every far-out idea that turns out to be true, there were probably hundreds that were simply crackpot ideas. In general, [science] advances building on the knowledge we have, and seeing what the n...

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#201 – Ken Goldberg on why your robot butler isn’t here yet

#201 – Ken Goldberg on why your robot butler isn’t here yet

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#200 – Ezra Karger on what superforecasters and experts think about existential risks

#200 – Ezra Karger on what superforecasters and experts think about existential risks

"It’s very hard to find examples where people say, 'I’m starting from this point. I’m starting from this belief.' So we wanted to make that very legible to people. We wanted to say, 'Experts think thi...

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#199 – Nathan Calvin on California’s AI bill SB 1047 and its potential to shape US AI policy

#199 – Nathan Calvin on California’s AI bill SB 1047 and its potential to shape US AI policy

"I do think that there is a really significant sentiment among parts of the opposition that it’s not really just that this bill itself is that bad or extreme — when you really drill into it, it feels ...

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#198 – Meghan Barrett on upending everything you thought you knew about bugs in 3 hours

#198 – Meghan Barrett on upending everything you thought you knew about bugs in 3 hours

"This is a group of animals I think people are particularly unfamiliar with. They are especially poorly covered in our science curriculum; they are especially poorly understood, because people don’t s...

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#197 – Nick Joseph on whether Anthropic's AI safety policy is up to the task

#197 – Nick Joseph on whether Anthropic's AI safety policy is up to the task

The three biggest AI companies — Anthropic, OpenAI, and DeepMind — have now all released policies designed to make their AI models less likely to go rogue or cause catastrophic damage as they approach...

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#196 – Jonathan Birch on the edge cases of sentience and why they matter

#196 – Jonathan Birch on the edge cases of sentience and why they matter

"In the 1980s, it was still apparently common to perform surgery on newborn babies without anaesthetic on both sides of the Atlantic. This led to appalling cases, and to public outcry, and to campaign...

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